Down Syndrome does not only affect the overall life quality of someone with this diesease, but can increase or decrease the chances of that individual from being diagnosed with cancer. Down syndrome, often referred to as DS, is a disease that is has an extra chromosome 21 or HSA21 gene, which causes the number one intellectual disability that is world wide. The child is born with this condition,but DS can be detected before the child is born. Not only does Down Syndrome cause intellectual disabilities,but they can begin physical and medical disabilities as well. People with Down Syndrome have an extra gene on the chromosomes 21 called Trisomy 21 and a third copy of the DSCR1 gene. The DSCR1 gene is also known as the RCAN1 gene which is what …show more content…
Leukemia is an abnormality in the blood where the cancer cells are in the blood,but DS children respond well towards chemotherapies and have a better survival rate. Myelodysplastic syndrome is found in the bone marrow and is pre-cancerous meaning that it more of a chance of becoming cancerous. Myelodysplastic syndrome is when abnormal cells take over the bone marrow and the platelet counts in the red blood cells decrease( Dixion 2-3). Transient myeloproliferative disorder is only found in newborn babies with Down syndrome. This is when the abnormal white blood cells grow rapidly,but only ten to twenty percent of babies develop transient myeloproliferative disorder. This can turn out to be cancerous or non-cancerous either can be present. Treatment varies for different babies and the abnormal cells may go away by themselves and will not need to find the best treatment plan, but no matter what the baby will need to be followed closely to make sure it goes away. WIth the abnormal white blood cells makes the body of someone with DS more prone to leukemia, but the leukemia will not develop in the child until later years( Dixion
Down’s syndrome is a chromosomal condition that is caused by an extra 21st chromosome as there is an error in the body’s cell division. Every human has a nucleus in every cell in the body which contains genes that are grouped along with chromosomes. The normal number of
Down syndrome is a disorder that comes with some defects, such as in the face, heart, sight, and hearing, and other health related problems. It also is the most common genetic defect, affecting many babies. Down syndrome is caused when the chromosomes are being divided during meiosis the cell keeps both copies of chromosome #21, which means the person with Down syndrome has an extra copy in every cell in their body. This is a sad genetic disorder that can change a person's life. Even though it is a devastating gene mutation, the people with Down syndrome are some of the most loving of all people.
Down Syndrome results when one of the three types of abnormal cell divisions involving chromosome 21 occur. Roger W. Harms, a medical doctor, states, “Human cells normally contain twenty-three pairs of chromosomes. One pair comes from your father and one pair comes from your mother.” In each pair, one chromosome comes from the father, and one comes from the mother. One of the three genetic variations that can cause Down Syndrome is Trisomy 21. This version of Down Syndrome occurs more than 90% of the time. It re...
“About 13 of every 10,000 babies born in the United States each year is born with Down syndrome. It affects an equal number of male and female babies” (Johnson P. A. 2014). Down syndrome is a genetic disorder that found across the world, however it is more prevalent in the United States. The cause of the disorder roots to the paring of the human chromosomes. A normal human receives 23 pairs of chromosomes, each pair coming from mother and father. In Down syndrome most people affected have an abnormal cell division of the chromosome. Both parents are carriers of the There are three types of variations that includes trisomy 21, mosaic, and translocation.
Most cases of Down syndrome are not inherited. When the condition is caused by trisomy 21, the chromosomal abnormality occurs as a random event during the formation of reproductive cells in a parent. The abnormality usually occurs in egg cells, but it occasionally occurs in sperm cells. An error in cell division called nondisjunction results in a reproductive cell with an abnormal number of chromosomes. For example, an egg or sperm cell may gain an extra copy of chromosome 21. If one of these atypical reproductive cells contributes to the genetic makeup of a child, the child will have an extra chromosome 21 in each of the body's cells.
In 1866 British doctor John Langdon Down defined and described the characteristic symptoms of Down Syndrome but was unsure of the cause. It wasn't until 1959 that Dr. Lejeunne and his team in Paris showed that people with Down Syndrome have an additional chromosome. We normally have 23 pairs of chromosomes, each made up of genes. The cells of people with Down Syndrome include three chromosome #21 instead of two. The extra 21st chromosome causes an extra dose of proteins. These proteins cause the typical features of Down Syndrome. While the fetus with Down Syndrome is developing, its body cells do not reproduce as fast as usual. That is the main reason why these babies are smaller than average after birth and their brain not as big as those of other newborn children.
Down's syndrome is not a disease and therefore people with Down syndrome do not suffer nor are they victims of their condition.Down Syndrome is a natural disorder coming from a chromosome defect. It is a genetic condition in which a person has 47 chromosomes instead of the usual 46. Which causes mental impairment and physical deformity.For example short stature , broad facial profile and weak muscle tone.It occurs in approximately one in every 800 live births.It is the most frequently occurring chromosomal disorder. Down syndrome is not related to race, nationality, religion or socioeconomic status.(medline plus)
of the cells, instead of the norm of two. Generally, Down syndrome is not hereditary since it is
It is a well known fact that all living things, humans included, are made up of cells. The nucleus of a typical cell in the human body is made up of 23 pairs of chromosomes. Half of the pairs come from each parent. In some individuals there is a full or partial extra copy of chromosome 21 present; these individuals have Down Syndrome (National Down Syndrome Society). Down Syndrome is a genetic disorder that most people know very little about. Since Down Syndrome is something that very few people know much about, this paper will include a lot of information about the disorder that is not well known to the general public. In this paper I will discuss what exactly Down Syndrome is and provide background information and history, describe how and when the disorder is diagnosed, provide insight of what life is like for a person with Down Syndrome and I will do my best to clear up many misconceptions that people often have about individuals with Down Syndrome.
Trisomy 21 is a chromosomal disorder. “It is caused by an extra chromosome 21.” (http://www.geneticcounselling.eu) This is due to nondisjunction. During meiosis a complication occurs which results in an extra chromosome. An offspring does not inherit Trisomy 21 (Down Syndrome), but other forms of the disorder can be passed along from a parent to a child.
Down syndrome is caused by a problem with a baby’s chromosome. Chromosomes are cell structures made up genetic DNA (“Chromosomes”). Most people with Down syndrome have 47 chromosomes. This changes the way the brain
Down syndrome, a genetic disorder, is the most common cause for intellectual disabilities, occurring at an average of one out of every 700 births (CDS, 2006). This disorder is caused by the extra chromosome 21 (also known as Trisomy 21). According to Hassold and Sherman (2002), the probability of giving birth to a child with DS is not linked to any race, ethnicity, socioeconomic status or geographic location. Maternal age seems to be the only etiological factor that may cause DS.
The cause of this disorder is because of an extra chromosome in the body. About 90% of Down Syndrome cases are caused by this extra chromosome, chromosome 21 (this is why it is also called Trisomy 21). An extra chromosome originates in either the sperm or the egg. When the egg and the sperm unite to form the fertilized egg, two instead of three chromosomes in chromosome 21 are present. As the cells divide the extra chromosome is repeated in every cell.
There’s a nucleus in every cell in the human body, where genetics is stored in gene. Codes are carried by the genes that are responsible for inherited traits are together as rod-like structures called chromosomes. Each nucleus contains 23 pairs of chromosomes. Both DNA from the parents are shared. Down syndrome is a genetic chromosome 21 disorder causing developmental intellectual delays.
The disease is known by the uncontrolled growth of blood cells, usually white blood cells in the bone marrow (“Leukemia Information”). The leukemia cells overcrowd and replace normal blood and marrow cells (“Leukemia Information”). Leukemia is likely to occur when when some blood cells have mutations in their DNA. There could be other changes in cells that could contribute to the forming of Leukemia (“Leukemia”). According to Leukemia Causes - Mayo Clinic, Certain abnormalities cause the cell to grow and divide more rapidly and to continue living when normal cells would die. Over time, these abnormal cells can crowd out healthy blood cells in the bone marrow, leading to fewer healthy white blood cells, red blood cells and platelets, causing the signs and symptoms of leukemia (“Leukemia”). Leukemia is classified based on its speed of progression and the type of cells involved