DEVELOPMENT AND EVALUATION OF CHLORPHENIRAMINE MALEATE ORALLY DISINTEGRATING TABLETS AND ORO DISSOLVING FILMS
INTRODUCTION:
Oral disintegrating tablets are also called as ‘mouth dissolving tablets’, ‘orodispersible tablets’, quick disintegrating tablets, rapid dissolving tablets, porous tablets and rapimelts1.
1.6 VARIOUS TECHNOLOGIES USED IN THE MANUFACTURE OF ODT:
The performance of ODT depends on the technology used in their manufacture. The orally disintegrating property of the tablet is attributable to a quick ingress of water into the tablet matrix, which creates porous structure and results in rapid disintegration. Hence, the basic approaches to develop ODT include maximizing the porous structure of the tablet matrix, incorporating the appropriate disintegrating agent & using highly water-soluble excipients in the
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The quicker the tablets will dissolve because there will be more water. particles to collide with. So the rate increases. * If the amount of tablets being used is increased for the same amount of water, i.e. as concentration increases, rate will increase. increase as well because there will be more collisions between particles.
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Firstly, an amount of 40.90 g of NaCl was weighed using electronic balance (Adventurer™, Ohaus) and later was placed in a 500 ml beaker. Then, 6.05 g of Tris base, followed by 10.00 g of CTAB and 3.70 g of EDTA were added into the beaker. After that, 400 ml of sterilized distilled water, sdH2O was poured into the beaker to dissolve the substances. Then, the solution was stirred using the magnetic stirrer until the solution become crystal clear for about 3 hours on a hotplate stirrer (Lab Tech® LMS-1003). After the solution become clear, it was cool down to room temperature. Later, the solution was poured into 500 ml sterilized bottle. The bottle then was fully wrapped with aluminium foil to avoid from light. Next, 1 mL of 2-mercaptoethanol-β-mercapto was added into fully covered bottle. Lastly, the volume of the solution in the bottle was added with sdH2O until it reaches 500 ml. The bottle was labelled accordingly and was stored on chemical working bench.
Terbinafine hydrochloride is a white, crystalline powder that is sold as Lamisil in tablet, cream, and powder form. ...
soluble. In other words, any way ap person gets it in his or her body, it will
This assignment will discuss the professional, legal and ethical issues related to the self-use of medication by nurses. It will also explore the importance of reporting this misconduct by both professionals in the scenario and how they might do so. The self-use of medication by nurses is not allowed or justifiable according to the guidance provided to nurses by An Bord Altranais (ABA 2007). It will also be evident throughout this assignment the need for Jack to report Linda’s self-use of the medication or urge Linda to do so regardless of the consequences it may present to both him and Linda as according to Nurses and Midwifery Board of Ireland (NMBI 2013), nurses can now be held responsible for not taking action. This is because delivering the greatest level of care to a patient is an essential role of a nurse and the main focus of the nurse’s work should be on caring for that patient (ABA 2010). There is also an ethical duty upon both nurses to report the misconduct according to the four ethical principles; Beneficence, non-maleficence, justice and autonomy (Edwards 2009).
As we discussed above that pharmacokinetic and pharmacodynamics can be seen as two sides of the same coin in order to gain better understanding of their efficacy and safety profiles.” Generally it is possible to make fairly robust predictions of the pharmacokinetic profile in man using in vitro systems and preclinical pharmacokinetic studies. A previously published survey on the causes of failure in drug development indicated that inappropriate pharmacokinetics were a major cause such as; factors as low bioavailability due to high extraction or poor absorption characteristics, short elimination half-life leading to short duration of action and excessive variability due to genetic or environmental factors. This observation has led to an increased emphasis on pharmacokinetic input to the drug discovery process throughout the pharmaceutical industry. However, it is important to realise that this may only permit the rejection of compounds to b...
My breaching experiment involved three social norms. These social norms forced people to be in an uncomfortable situation and make a decision as to how they should react to it. The first social norm I experimented with was sitting next to someone in an uncrowded movie theater. I chose this because of the awkwardness it caused. At all three of my trials, occurring from 1-9 pm, there were over fifty empty seats at Carmike on February 21st. The next social norm I analyzed was sitting in someone’s assigned seat. This was chosen because I felt it would be engrossing to observe the different reactions fellow high school students retaliated with, all being different races. At Liberty High School I took someone’s assigned seat five different times,
The pure compound melting point should be in the range of 169-172 ℃. During this lab practical Paracetamol- acetaminophen will be synthesis, purified and recrystallized again. The purpose of the experiment was to learn basic recrystallization techniques that include hot and cold filtration
Due to its strong effect, it is often advised to swallow the pill whole rather than sucking or chewing on it because it can cause irritation in the food pipe.
Oral bacteria have a narrow pH range of 5.5 to 8 [7], yet citric acid has a low pH of 2.2 [8], hence making the product antibacterial. I have high expectations for this product because usually, natural products seem to work very effectively and efficiently than commercial, man-made products. Such as soap products for example, commercial soap products have ingredients which are sometimes harmful and usually natural products have ingredients which are good and healthy for the skin[12].
A supplement that is progressively becoming more popular in the United States are diet Pills. The purpose of consuming these pills is to help individuals lose weight in a easy manner. Diet pills come in many different variations that contributes to certain tasks in the body. Diet pills alone can have a dangerous effect on the body let alone being knowledgeable in knowing what diet pills are best for your body is very important. People who are consuming or looking into consuming diet pills often forget to look further into the product due to desperation. Everyone already knows that the best way to lose weight is by exercising and eating healthy; but since people are not taking that into consideration, it’s best to believe they are to the point
However, the polarities should not be the same as this will cause the compound to completely dissolve in the solvent (1). The second procedure dealt with finding a suitable solvent to recrystallize the crude acetanilide. A sand bath was set up and 0.5 mL of each solvent was added to 50 mg of acetanilide in four different test tubes. The four solvents used to test the solubility of the acetanilide were water, ethanol, dichloromethane and hexanes.
Antimicrobial Packaging: Edible films are produced which incorporate cinnamon, zinc, calcium, oregano oil or other materials that can kill bacteria.