Diabetes Mellitus

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I. Name of Disorder: The official name of the disorder is Diabetes Mellitus. Most people just know it as diabetes. There are two major classifications of diabetes mellitus; insulin-dependent (IDDM) and noninsulin-dependent (NIDDM). IDDM is more commonly known as Type 1 Diabetes, and NIDDM is known as Type 2 Diabetes (Ekoé, 2008). Type 1 diabetes is the juvenile-onset diabetes that deals with the complete destruction of β-cells of the pancreas whereas type 2 diabetes is an adult-onset disorder in which individuals suffer from an insulin deficiency (Ekoé, 2008). II. Chromosomal location: The main location of diabetes type 1 or IDDM is on the short arm of chromosome 6 at the band 21.3. IDDM is mostly influenced by the HLA class II region (Ekoé, 2008). Diabetes type 2 or NIDDM is located on several different chromosomes, and even different arms. The chromosomes that contain NIDDM are chromosomes 2-8, 10-13, 15, 17, 19, and 20. III. Type of Inheritance: Diabetes Mellitus is a multifactorial disorder; it is effects by both genes and the outside environment. Type 1 diabetes is shown to have a similarity throughout families, but there is no distinct pattern of inheritance (Savage & Bain, 2013). Geneticists are in a total controversy over the actual mode of inheritance of IDDM. There are hypotheses that it is autosomal recessive, autosomal dominant, some autosomal dominant and some autosomal recessive, intermediate gene dosage model, a heterogeneity theory, and a two-locus disorder (Rotter, 1981). The mode of inheritance that is most supported and accepted would be the heterogeneity because a single genetic disorder (IDDM) is caused by multiple alleles (Rotter, 1981). Type 1 diabetes also falls under heterogeneity because of the conc... ... middle of paper ... ...abetes mellitus, or the genetics of IDDM, no longer a nightmare but still a headache. Am. J. Hum. Genet. 33: 835-851, 1981. [PubMed: 7034532]. Savage, David A., and Stephen C. Bain. "Genetics of type 1 diabetes mellitus." Oxford Textbook of Endocrinology and Diabetes. Oxford, UK: Oxford University Press, 2011-07-01. Oxford Medicine. 201107. Date Accessed 14 Nov. 2013 9780199235292-chapter-130202> Stene, Lars C., Jaakko Tuomilehto, and Marian Rewers. "Global Epidemiology of Type 1 Diabetes." The Epidemiology of Diabetes Mellitus. Oxford: Wiley-Blackwell, 2008. 355 83. Print. Wolfs, M. G.M., M. H. Hofker, C. Wijmenga, and T. W. Van Haeften. "Type 2 Diabetes Mellitus: New Genetic Insights Will Lead to New Therapeutics." Current Genomics 10.2 (2009): 110-18. Ncbi. 10 Apr. 2009. Web. 14 Nov. 2013.

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