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Pathophysiology of diabetes essay
Pathophysiology of diabetes essay
Pathophysiology of diabetes essay
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Diabetes Mellitus is a disorder in which blood levels of glucose are abnormally high because the body doesn’t release or use insulin adequately. Diabetes Mellitus affects many organs of the body. It affects the blood vessels because Atherosclerotic plaque builds up and blocks large or medium-sized arteries in the heart, brain, and legs. The walls of small blood vessels are damaged so that the vessels do not transfer oxygen normally and may leak. This can lead to poor circulation and can hinder the healing of wounds, cause heart disease, stroke, gangrene of the feet and hands, and infections. The eyes are also affected. The small blood vessels of the retina become damaged leading to decreased night vision and ultimately blindness. Poor kidney function and kidney failure may also arise due to thickening of the blood vessels in the kidneys. Protein leaks into the urine and the blood is not filtered normally. Skin is greatly affected by diabetes Mellitus. There is poor blood flow to the skin which causes loss of feeling. Sores and deep infections called diabetic ulcers occur because of this.
Pregnancy is affected by diabetes Mellitus. Many changes that take place during pregnancy make controlling blood sugar more difficult for a woman who has diabetes. Changes in the levels and types of hormones produced during pregnancy can cause insulin resistance, increasing the body’s requirements for insulin. Poorly controlled diabetes may endanger the fetus as well as the woman. With proper adjustments in insulin the risks lessen. Diabetes increases a pregnant woman’s risk of infection, early labor, and high blood pressure caused by pregnancy. The baby of a diabetic woman may be unusually large at birth. The risk of birth defects is two times higher in babies of women who have diabetes. Most women who have diabetes can have vaginal deliveries. After birth, the babies are assessed carefully because they are at increased risk of developing breathing difficulties, low blood sugar and calcium levels, jaundice, and a high red blood cell count. These problems are temporary and can be treated.
Six percent of the United States population has some form of diabetes. Ten percent have type 1 form of the disease. Most people who have the disease develop it before age 30. Scientists believe that an environmental factor causes the immune system to destroy the insulin—producing cells in the pancreas. Some genetic link is most likely needed for this to happen.
4: Evers IM, De Valk HW, Visser GHA (2004) Risk of complications of pregnancy in women with Type 1 diabetes: Nationwide prospective study in the Netherlands. British Medical Journal 328, 915-917.
According WebMD 2014. Diabetes mellitus (or diabetes) is a chronic, lifelong condition that affects your body's ability to use the energy found in food. There are three major types of diabetes. Type 1 diabetes mellitus, type 2 diabetes mellitus and gestational diabetes. It is a hormonal disorder of the pancreas either decrease in insulin level also known as hypoinsulinism or increase in insulin level also known as hyperinsulinism. Lowered amounts, insufficient of, or ineffective use of insulin leads to the disorder of diabetes mellitus. It is common chronic disease requiring lifelong behavioral and lifestyle changes. According to Peakman (2012). The development of type 1 diabetes mellitus is a genetic and an autoimmune process that results in destruction of the beta cells of the pancreas, leading to absolute insulin deficiency. There is usually a pre-diabetic phase where autoimmunity has already developed but with no clinically apparent insulin dependency. Insulin autoantibodies can be detected in genetically predisposed individuals as early as 6-12 months of age. In persons genetically susceptible to type 1 diabetes, a triggering event, possibly a viral infection the leads to production of autoantibodies that kill the beta cells and results in decline and a lack of insulin secretion. According to Wherrett. It is caused by impaired insulin secretion and insulin resistance and has a gradual onset. Those with type 2 diabetes may eventually need insulin treatment. Gestational diabetes mellitus is glucose intolerance during pregnancy in a woman not previously diagnosed with diabetes, this may occur if placental hormones counteract insulin, causing insulin intolerance. Complications in diabetes mellitus includes: Hypoglycemia it is ca...
Type 1 Diabetes Mellitus is also referred to as insulin-dependent as the secretion of the hormone insulin by the pancreas is reduced to minor levels due to the destruction of the pancreatic beta cells by immune system of the body. Therefore, Type 1 Diabetes is an autoimmune condition due to the fact that the body is harming the pancreas with antibodies so beta cells cannot make any insulin for bloodstream to take in glucose. The fact that the cells in the body cannot take in glucose means that it builds up in the blood and hyperglycaemia occurs. This abnormally high level of blood glucose is able to harm the nervous system, tiny blood vessels in the kidneys, heart and the eyes. Type 1 Diabetes is fatal when left untreated as it then causes heart disease, kidney disease, damage to the nerves, stroke and
The pathophysiology of diabetes mellitus in is related to the insulin hormone. Insulin is secreted by cells in the pancreas and is responsible for regulating the level of glucose in the bloodstream. It also aids the body in breaking down the glucose to be used as energy. When someone suffers from diabetes, however, the body does not break down the glucose in the blood as a result of abnormal insulin metabolism. When there are elevated levels of glucose in the blood, it is known as hyperglycemia. If the levels continue to remain high over an extended period of time, damage can be done to the kidneys, cardiovascular systems; you can get eye disorders, or even cause nerve damage. When the glucose levels are low in one’s body, it is called hypoglycemia. A person begins to feel very jittery, and possibly dizzy. If that occurs over a period of time, the person can possibly faint. Diabetes mellitus occurs in three different forms - type 1, type 2, and gestational.
While a woman is generally safe from complications from gestational diabetes, there are some very big risks to the baby. If gestational diabetes goes undiagnosed, there is a greater risk of stillbirth. Other complications can include a condition called macrosomia, where the baby is born weighing 9 ¾ pounds or more. Excessively large babies can make delivery more difficult for both mother and child and as a result, birth injuries are more common in these babies. Other problems include hypoglycemia in the baby shortly after birth. The risk of gestational diabetes is higher in women who are over 30 years old, have a family history of diabetes, are obese, and those who have previously had a macrosomic baby.
Is a multisystem disease related to abnormal insulin production, impaired insulin utilization, or both. Diabetes Mellitus is a serious health problem throughout the world. It is the 5th leading cause of death in the U.S. It is the leading cause of heart disease, stroke, adult blindness, and nontraumatic lower limb amputations.
Diabetes is a disease that affects the body’s ability to produce or respond to insulin, a hormone that allows blood glucose (blood sugar) to enter the cells of the body and be used for energy. Diabetes falls into two main categories: type 1, or juvenile diabetes, which usually occurs during childhood or adolescence, and type 2, or adult-onset diabetes, the most common form of the disease, usually occurring after age 40. Type 1 results from the body’s immune system attacking the insulin-producing cells in the pancreas. The onset of juvenile diabetes is much higher in the winter than in the summer. This association has been repeatedly confirmed in diabetes research. Type 2 is characterized by “insulin resistance,” or an inability of the cells to use insulin, sometimes accompanied by a deficiency in insulin production. There is also sometimes a third type of diabetes considered. It is gestational diabetes, which occurs when the body is not able to properly use insulin during pregnancy. Type 2 diabetes encompasses nine out of 10 diabetic cases. Diabetes is the fifth-deadliest disease in the United States, and it has no cure. The total annual economic cost of diabetes in 2002 was estimated to be $132 billion, or one out of every 10 health care dollars spent in the United States. Diabetes risk factors can fall into three major categories: family history, obesity, and impaired glucose tolerance. Minority groups and elderly are at the greatest risk of developing diabetes.
B.(Sub-point) Type-2 diabetes after a long time can affect the body’s blood vessels leading to damage to both small and big vessels just like Type 1 diabetes. (SUB-SUBPOINT) Damage to the small blood vessel leads to microvascular problems, while harm to the large vessels result in macrovascular effects (Lisa, 2016). Impaired blood vessels do not transfer blood as supposed to, which results in other complications, like vision loss, kidney damage and nerve damage. Macrovascular problems with Type 2 diabetes are a buildup of plaque, which results in a heart attack, blocked vessels in legs and a stroke (Lisa, 2016). Type 1 diabetes has the same complications as Type 2 resulting in the same effect on the important organs in the body, like the heart, nerves, vision, kidneys and both the tiny and large blood vessels ( Mayo Clinic Staff,
Diabetes refers to a set of several different diseases. It is a serious health problem throughout the world and fourth leading cause of death by disease in the country. All types of diabetes result in too much sugar, or glucos in the blood. To understand why this happens it would helpful if we understand how the body usually works. When we eat, our body breaks down the food into simpler forms such as glucose. The glucose goes into the bloodstream, where it then travels to all the cells in your body. The cells use the glucose for energy. Insulin, a hormone made by the pancreas, helps move the glucose from bloodstream to the cells. The pathophysiology of diabetes mellitus further explains the concept on how this disease works. Pancreas plays an important role of the metabolism of glucose by means of secreting the hormones insulin and glucagon. These hormones where then secreted by Islets of Langerhans directly to the blood. Inadequate secretion of insulin results on impaired metabolism of glucose, carbohydrates, proteins and fats which then result to hyperglycemia and glycosuria. Hyperglycemia is the most frequently observed sign of diabetes and is considered the etiologic source of diabetic complications both in the body and in the eye. On the other hand, glucagon is the hormone that opposes the act of insulin. It is secreted when blood glucose levels fall.
Type 1 diabetes has a genetic onset that often occurs in adolescence (Porth, 2005). It is an autoimmune disease in which the insulin-producing beta cells within the liver are destroyed (Dorman, 1993). This causes a deficiency in insulin secretion, which ultimately leads to high blood glucose levels, also referred to as hyperglycemia (Guthrie & Guthrie, 2004). The mechanism for insulin deficiency leading to hyperglycemia is described in more detail in the following section and in Figure 1.
Gestational diabetes mellitus (GDM) is an intolerance of glucose documented for the first time during pregnancy. It is usually a short-term type of diabetes and the most common health problem with pregnant women. GBM is caused by the way the hormones in pregnancy affect the mother. GDM accounts for 5-7% of all pregnancies (American Diabetes Association, 2010). During pregnancy the placenta develops and becomes the main bond between the mother and the baby. It is used to make sure the baby has and gets enough nutrients. The placenta makes several hormones which make it hard for insulin to control blood glucose and block the action of the mother’s insulin in her body (American Diabetes Association, 2010). Hormonal changes during the pregnancy causes the body to be less sensitive to insulin. Insulin has the job of opening up the cells so that the glucose can get inside regulating the amount of glucose in the blood while glucose is the amount of sugar in the blood stream. In pregnancy, the body needs to make three times more insulin for control of the blood sugar. GDM is usually found within the second trimester of a pregnancy and increases until the end of the pregnancy. Usually within a few hours of delivery the condition resolves itself (American Diabetes Association, 2010).
Diabetes type 1 occur when the immune system destroys the beta cells, they are responsible to create insulin and are located
Gestational diabetes is a form of diabetes that occurs during pregnancy. Although it usually goes away after the baby is born, it does bring health risks for both the mother and baby. When you’re pregnant, pregnancy hormones make it harder for insulin to move glucose from your blood into the cells. If your body can’t produce enough insulin to overcome the effects of insulin resistance, you’ll develop gestational diabetes. (IHC, 2013)
Diabetes is a disease that I came across when researching my maternal side of my family history. Diabetes is a disease that affects your pancreas an important organ in regulating blood sugar. When a person has diabetes there are two ways it can affect the pancreas because there are two types of the disease. Type-1 diabetes affects the pancreas by not allowing the body to produce enough insulin to keep the body’s blood sugar at a healthy number. The opposite is for Type-2 which produces too much insulin and gives the body too much insulin keeping the blood sugar number above healthy (Type-2).