Some males with this disease are sterile while some females have thick vaginal secretions that impair sperm motility. Cardiac complications such as congestive heart failure are common as well and are often contributing factors to the morbidity of this disease. Heredity With cystic fibrosis being an auto recessive single gene disease a person must inherit one mutant allele of the cystic fibrosis gene from both parents. There is a complex relationship between the genotype and phenotype with variable pentrance ("Cystic fibrosis," 2012). One can predict the chances of the phenotype inheriting the cystic fibrosis gene from the genotype.
Cystic Fibrosis inherits two faulty genes for the disease from both parents. This condition is most common in white people of Northern European ancestry. It affects the production of mucus, sweat, digestive juices and infertility. The mucus becomes thick and sticky, blocking the airways, which leads to recurrent infections. Cystic fibrosis causes a person’s sweat to become salty, which upsets the balance of minerals in the blood and causes health problems.
What is Cystic Fibrosis? Cystic fibrosis (CF) is a common inherited disease affecting children and adults. Cystic fibrosis is a disease of the secretory glands, such as the glands that make mucus and sweat and this multi-system disease most commonly affects the lungs and digestive system of humans. This happens because thick mucus is produced by the body from a defective gene on Chromosome 7 and its protein product. The thick mucus causes lung blockage which leads to severe respiratory problems.
The bronchitic with a great deal of emphysema, who has lost a lot of his or her oxygen cc exchanging ability, due to the condition, is short of breath at all times. The bronchitic with emphysema very often are underweight and, as the disease comes worse, develops a barrel chest. The Chronic bronchitic also wheezes because of the obstruction. NOTE: Emphysema is a state of overdistention of the tiny air-containing sacs of the lung. The cause of bronchitis are from viral or bacterial infections which spreads to the chest.
Granulomas are cluster of immune cells. When are too many granulomas form in an organ it affects how the organ works. Doctors think people with sarcoidosis have genes that make it easier for them to get the disease. Things that might trigger it are infections, bacteria, viruses, dust, or chemicals. Scientists also believe that sarcoidosis is immune system disease, because the body is attacking itself and by the failure of the immune system to fight off the disease.
Excessive bleeding on the menstrual cycle, nose bleeds, and jaundice. The enlarged spleen has too many platelets causing it to decrease. The disease also consists of leukemia or a viral infection. The increased breakdown that is caused by some things with the condition. Also serve options lead to a transfusion or finding an underlying.
The two main types of skin cancer are melanoma and non-melanoma. Melanoma is much more dangerous than non-melanoma. If it isn't found early enough, it can be fatal. Non-melanomas are benign. People should be careful if skin cancer is dominant in earlier generation of their family, because the are more likely to inherit it.
PNH also damages platelets (thrombocytes) interfering with the ability to form blood clots, because of th... ... middle of paper ... ...destroys PNH by transplanting healthy marrow (most often from a relative) into the patient. There is a VERY high mortality rate with this cure so generally it is reserved for patients who suffer from PNH along with another disease such as leukemia, aplastic anemia, or myelodysplastic syndrome and all other treatment options are no longer enough. Works Cited http://www.ncbi.nlm.nih.gov/books/NBK22166/ http://ghr.nlm.nih.gov/condition/paroxysmal-nocturnal-hemoglobinuria http://www.nlm.nih.gov/medlineplus/ency/article/003642.htm http://www.nlm.nih.gov/medlineplus/ency/article/000534.htm http://en.wikipedia.org/wiki/Paroxysmal_nocturnal_hemoglobinuria#Treatment http://rarediseases.info.nih.gov/GARD/Disease.aspx?PageID=4&DiseaseID=7337 http://bloodjournal.hematologylibrary.org/content/113/26/6522.full http://www.haematologica.org/cgi/content/full/95/6/855
Biology 101 Cystic fibrosis which is also known as mucoviscidosis or CF, is a disease that is common to the human body that result to progressive disability and sometimes death. The disease is considered to be life-shortening as it affects the exocrine glands composing of the sweat glands and the pancreas (Heyward and Wagner, 2004, p. 5) and negatively impact on the respiratory systems and the gastrointestinal tract. Cystic fibrosis is normally described as a chronic obstructive pulmonary disease, irregular and soaring electrolyte levels, and insufficiency of exocrine in the pancreas. The disease is usually rampant for the Caucasian people and almost 70 percent of patients hit by the disease are adolescents and children. Human phenotype of cystic fibrosis is characterized by the production of mucus that tends to block the ducts of specific glands and the passages of the lungs which is fatal in the early part of adulthood.
This results in the mucus becoming thick and sticky, which causes problems to people with cystic fibrosis (Alma). Normally, mucus is a slippery, watery substance that lines organs to keep them moist and prevent drying out or getting infected, but when one has cystic fibrosis, mucus is thick and sticky. The thick mucus builds up in the lungs and blocks the airways, which makes it easy for bacteria to grow. When the bacteria begin to grow, it leads to serious lung infections and over time causes severe damage to your lungs (“What is Cystic Fibrosis?”). Digestion problems can occur when the thick mucus block... ... middle of paper ... ...ine, 2012.