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DNA Replicaiton Cause Cancer

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Part A : Defects in DNA Replication Cause Cancer

I. Introduction

As known today, cancer is one of the most lethal diseases in the world. Millions of people died every year caused by various type of cancer, but the concern is that what does really caused the cancer itself? Is it because of the lifestyle people have nowadays? Or because of environment that has changed? Or even sometimes because of the flaw in the replication of DNA? There are lots of probabilities to cause cancer.
In this section, we will discuss about how does DNA replication could end to cause cancer.

II. Replication of DNA

DNA replication is a process to create two identical molecules of DNA by unification of the DNA on the parent DNA (DNA template). New DNA strands produced in the 31 to 51 direction. This process involve 6 major enzymes, it is Helicase, RNA Polimerase, DNA Polimerase III, DNA Polimerase I, DNA Gyrase, and DNA Ligase (Varughese, 2014).
Function of each enzymes explained as written below :
Helicase : Unwind the 2 strand DNA.
RNA Polimerase : Synthesis the short RNA primer strand.
DNA Polimerase III : Extends the RNA primer with short DNA that complete the strands.

DNA Polimerase I : Assimilate the primer RNA and replace it with DNA.

DNA Ligase : Incorporating the neighboring fragments into a new longer stretches.

DNA Gyrase : Release the stretches.
III. Defects in DNA Replication

DNA is the base of human cells, so to prevent blemish to the cells the DNA must be replicated perfectly, but what will happen if the DNA fail to achieve that perfection? Or in other words there’s a flaw on the progress of replication? In this section, we will look closer into it and see what will happened if in some case ...

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