Cystic Fibrosis Pathophysiology

Cystic Fibrosis (CF)

Pathophysiology:

Cystic fibrosis is a genetic disease of the secretory glands that affects the respiratory and digestive system. It mainly effects the lungs, pancreas, liver, intestines, sinuses, and reproductive organs. Cystic fibrosis effects the cells that produce sweat, mucus, and digestive fluids. Mucus becomes thick and sticky causing build-up in the lungs and blocking airways; making it easier for bacteria to develop. This prompts repeated lung infections and can cause severe lung damage after some time. The thick mucus can also block ducts in the pancreas. Therefore, digestive enzymes can't reach the small intestine. Without the digestive compounds used to break down food, the intestines can't completely absorb vital supplements. CF also causes sweat to become salty. When patients with cystic fibrosis sweat, a large amount of salt is secreted, which can agitate the equalization of minerals in the blood and cause numerous health issues.

.Symptoms:

• Pain in the abdomen

• Burning in chest

• Chest cold

• Chronic cough with blood or phlegm

• Pulmonary hypertension

• Pneumonia

In any case, it might bring about different complications in the reproductive and musculoskeletal. For example, infertility in men and women and low bone density. Patients with cystic fibrosis frequently have lung diseases caused by germs that don't react to anti-biotics. Infections, for example, sinusitis, bronchitis, and pneumonia add to long term lung damage. Cystic Fibrosis also causes damage to the pancreas because the thick mucus blocks tubes, and ducts; preventing enzymes to reach the intestines. When this happens, the digestive system is unable to ingest fundamental fats and proteins causing diarrhea, serious constipation, and intestinal blockage. As CF worsens, more serious manifestations rise like bronchiectasis, pancreatitis, hepatopathy, and