Crystal Engineering: Crystal Engineering

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CHAPTER 1 INTRODUCTION 1.1. Crystal Engineering The term crystal engineering was coined by Pepinsky in 1955 [1], and was first used in studies in 1971 by Schmidt seeking to define the term “crystal enginerring” in connection with topochemical reactions in crystalline cinnamic acids [2]. It has since expanded into the field of supramolecular chemistry, which deals with the interaction of molecules in a crystal through non-covalent bonds such as hydrogen bonding [3]. Crystal engineering has been defined as “the understanding of intermolecular interactions in the context of crystal packing and the utilization of such understanding in the design of new solids with desired physical and chemical properties” [4]. Crystal engineering is often based…show more content…
the assembled molecules, bound together with intramolecular interactions instead of covalent bonds. Supramolecular synthons have been defined by Desiraju [21] as “structural units within supermolecules which can be formed and/or assembled by known or conceivable synthetic operations involving intermolecular interactions”. The key in designing cocrystals is choosing a synthon, which is likely to form in a crystallization process, like a synthetic chemist chooses known reactants to make a specific covalent bond. Most often the synthons involve hydrogen bonds [22] because of their strength and directionality, but other interactions such as halogen bonding [23, 24] can also be used. Aromatic π- π interactions and van der Waals forces do not yet have much use in cocrystal design, but they are not to be overlooked in experiments because they contribute to the final outcome of…show more content…
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