Critical Review Essay

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Angela Huang
Critical Review Form
Quantitative Studies
TITLE of your article:
European, randomized, phase 3 study of lisdexamfetamine dimesylate in children and adolescents with attention-deficit/hyperactivity disorder

STUDY PURPOSE:
Was the purpose stated clearly? __x_ Yes ___ No
Outline the purpose of the study (i.e., study objective or aim):
The purpose of this study was to compare the efficacy of using a stimulant versus a placebo in children and adolescents aged 6-17 years old. The drugs used in this study included the stimulant, lisdexamfetamine dimesylate, OROS-MPH (osmotic-released oral system methylphenidate as a reference arm), and placebo.
LITERATURE:
Was relevant background literature reviewed? __x_ Yes
___ No
Describe the justification of the need for this study (3-4 key points)
⇒ ADHD can be a difficult disorder to treat and choosing the …show more content…

The ADHD-RS-IV scores of participants treated with LDX decreased by over 50% from baseline and patients overall tolerated LDX well.
What were the main limitations of the study as stated by the author(s) and from your point of view?
The authors stated that since ADHD is underdiagnosed in Europe, patients may have had more of response to medication versus placebo due to the severity status of their ADHD. From my point of view, the study is limited in a few different ways. For example, the study was composed of predominantly males and there weren’t as many female participants. It would be helpful to see if we could apply the same efficacy measures to females. Also, the majority of the study population were Caucasian so it would be difficult to apply this to other ethnicities like African American, Hispanic, or Asian populations.
What are the implications of these results for your

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