Clozapine Case Study

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d) For this scenario you are a community pharmacist and wish to begin dispensing clozapine for one of your patients presenting with a PBS Authority for clozapine. What steps will you need to take prior to dispensing the clozapine for the patient?
1. pharmacists must meet all relevant PBS, state and clozapine monitoring system requirements in order to participate.
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2. The pharmacist must check the patient's pathology results and details entered into the brand-specific clozapine patient monitoring database before they dispense or claim.
3. pharmacists must be registered with the appropriate patient monitoring system before prescribing or dispensing of clozapine can occur.
4. Community pharmacists must use the streamlined Authority code indicated …show more content…

(2015, June 25). Retrieved April 29, 2017, from http://www.pbs.gov.au/general/changes-to-certain-s100-programs/faqs-hsd-ca-clozapine-25-june-2015.pdf
e) What lifestyle factors can influence the therapeutic levels of clozapine? Explain how they affect the therapeutic levels of clozapine
From the factors that influence the clozapine levels is smoking because it induces CYP1A2 enzyme and increases the metabolism of clozapineleading to decreased levels in the blood. Therefore,in cases of sudden cessation of smoking, the concentration of clozapine in the blood may be increased,thus leading to adverse effects.
Also clozapine levels are affected by caffiene intake for example tea,coffee and cola drinks. Caffiene is an inhibitor of CYP1A2 which will increase the concentration of clozapine in plasma.
Referance …show more content…

Questions to asked is
1- What symptoms do you have?
2- What other medication are you taking?
3- Do you have any other medical condition?

Reference
Drug Interaction Report. (n.d.). Retrieved April 29, 2017, from https://www.drugs.com/interactions-check.php?drug_list=709-364%2C924-490

g) Myocarditis is a rare side effect of clozapine. Describe the signs and symptoms of myocarditis
1- Primary Symptoms of myocarditis resembles symptoms of influenza like fever and malaise
2- Shortness of breath
3- Abnormal heartbeat
4- Light-headedness
5- Chest pain
6- fatigue
Reference
1-What You Should Know: Myocarditis. (n.d.). Retrieved April 29, 2017, from http://www.webmd.com/heart-disease/myocarditis#1

2- Clozapine-induced Myocarditis - Monitoring Protocol. (2012, January 19). Retrieved April 29, 2017, from

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