“Clostridium Difficile are the bacteria that can cause irritation or swelling of the large intestine, or colon. The inflammation caused by this bacteria is known as colitis.
Inflammation further causes diarrhea, fever, and abdominal cramping” (WebMD, C. Diff.
Overview 2015). Put it all together and you get Clostridium Difficile Colitis.
In 1973, John G. Bartlett began to see the connection between hospital diarrhea cases and colitis. He recognized articles with series of cases including deaths from various places. Bartlett figured “the pathological course of this illness was a severe inflammatory process with and without pseudomembranes, which involved the large intestine”(Oxford Journal, clinical infectious diseases 2014). 1975 Bartlett mobilized …show more content…
“The first step in the discovery process was adapting the hamster model of antibiotic-associated colitis. This was accomplished by demonstrating the pathological similarities, then the relationship to clindamycin exposure, and finally the beneficial effect of vancomycin treatment”( Oxford Journal, clinical infectious diseases 2014). The
Hamster model progressed the studies on treatments for the disease and set in motion the process of identifying the caustic microorganism. “They identified the caustic microorganism two years later by first discovering a toxin-producing clostridium in the cecum; or pouch connected to the junction of the small and large intestines; of infected hamsters”(Oxford Journal, Clinical infectious diseases 2014). The disease was originally labeled incorrectly as C. sordellii, however in 1978, Bartlett corrected them that C. difficile in fact played the pathogenic role in the disease. Lastly the discovery of the cytotoxin assay was an absolute breakthrough that led to unraveling the Clostridium
Difficile toxin story.
Clostridium Difficile Colitis 4
The symptoms for Clostridium difficile colitis are horrible. They include bloody