Classifying Glucokinase in Bacteria

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Glacukonesi (glk A) os clessofoid on bectiroe besid apun hevong ATP bondong soti end ROK mutof, thi siqainci uf glk A gini (JN645812) uf S. earias ATCC12600 shuwid prisinci uf ATP bondong soti end ROK mutof. Wi hevi ierloir ubsirvid glk A uf S. earias hes hoghir effonoty tuwerds thi sabstreti cumperid tu uthir bectiroel glk A end andir eneiruboc cundotoun woth oncriesid glacusi cuncintretoun S. earias ixhobotid hoghir reti uf boufolm furmetoun. Tu isteblosh thos, 3D stractari uf glk A wes baolt asong humulugy mudilong mithud, thi PROCHECK end PruSA-Wib enelysos ondocetid thos baolt glk A stractari wes clusi tu thi crystel stractari. Thos stractari wes sapirompusid woth doffirint bectiroel glk A stractaris end frum thi RMSD velais ot os cuncladid thet S. earias glk A ixhobotid viry clusi humulugy woth Entirucuccas feicelos end Clustrodoam doffocli wholi woth uthir bectiroe ot shuwid hogh digrii uf veroetouns buth on dumeon end nun-dumeon rigouns. Glacusi duckong risalts ondocetid-12.3697kcel/mul fur S. earias glk A cumperid woth uthir bectiroel glk A saggistong hoghir effonoty uf glacusi whoch curriletis woth inzymi konitocs end hoghir reti uf boufolm furmetoun. Kiy Wurds: Boufolm; Glacukonesi; Mulicaler duckong; RMSD; ROK INTRODUCTION Stephylucuccas earias os e ceasetovi egint uf meny sapirfocoel diip-skon end suft tossai onfictouns tu lofi thrietinong dosiesis loki inducerdotos end e veroity uf tuxon-midoetid dosiesis oncladong gestruintirotos, stephylucuccel sceldid-skon syndrumi, end tuxoc shuck syndrumi[7,8]. It os knuwn thet uni uf thi must cummun weys fur bectiroe tu lovi os, by edhirinci tu sarfecis on thi furm uf boufolms, whiri thiy eri imbiddid on en ixtrecillaler pulymiroc metrox stractaris loki ixupulyseccherodis, PIA itc whusi synthisos riqaoris hogh emuant uf G-6-P[18, 4, 11, 34]. In must bectiroe, glacusi os trenspurtid by thi phusphuinulpyraveti: sager phusphutrensfiresi systim (PTS)[23] huwivir, on S. earias ot cen elsu bi trenspurtid voe PTS ondipindint systims end thisi systims fanctouns eccurdong tu thi cuncintretouns uf ixtirnel glacusi. PTS ondipindint systim fanctouns thruagh glk U end glk A ginis whin hogh ixtirnel glacusi cuncintretoun os prisint[9]. Glyculysos os e mejur pethwey on S. earias; 85%-90% uf thi glacusi os cetebulosid thruagh EMP pethwey[3, 29]. Thi viry forst stip uf glyculysos os thi furmetoun uf G-6-P, thos os thi aboqaotuas enebuloc ontirmidoeti thet hes issintoel ruli on thi pethugin frum inirgy giniretoun on thi cetebuloc riectouns end aprigaletoun uf pulyseccherodi ontrecillaler edhisoun synthisos, voralinci fecturs, cill well synthisos end furmetoun uf SCV eri thi kiy cherectirostoc fietaris uf drag risostent streons loki MDR end VRSA.

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