Recent development in the field of genetics has led to significant change in the way genetics contribute in medicine. Genomics is the human genetic information lying inside the nucleus of a human cell, which provides all the qualities, physical and psychological characteristics of a living organism. Classical genetic is a term which means the methods and techniques used in the study of genetics before the advent of molecular biology these techniques are: genetic and SNP (Single-nucleotide polymorphism) mapping. Among the most important discoveries of classical genetics so-called genetic association in Eukaryotes that lead to a phenomenal researRecent development in the field of genetics has led to significant change in the way genetics
contribute
…show more content…
Nevertheless, classical genetics are no longer pertinent in the detection of genetic disorder diseases such as asthma and several other pathologies. The difference between genetics and genomics is that genomics deals with the whole genes instead of a particular gene of interest and classical genetics is a significant part in genomics that can be very useful when detecting hereditary diseases. Furthermore, medicine do depends on the approach of how traits are passed from generation to another but the mechanism of these genes and how they work is the significant part in modern medical science which cannot be identified using classical genetics. Although, Mendelian genetics do have a significant contribution in medicine, this essay will demonstrate that the usage of advanced genetic techniques and molecular biology approaches are more relevant in the field of medicine then Mendelian …show more content…
The other way to deliver genes is a method of ICSI (Intra-cytoplasmic sperminjection) microinjection used for that an absorbent in the form of a very fine needle operate in an electro portion manner, where they enter the genetic material into the cytoplasm or the nucleus and the most ideal way is to use viruses as vectors in gene transfer. There are two types of viruses, one DNA and other type RNA and there are chemical variations between the two viruses, both are formed from units of nucleotides, in addition to the sequence of precise rules of nitrogen. Most of the RNA viruses are not suitable for gene therapy because of that RNA cannot be associated with DNA of human cells except Retroviruses where viruses can convert RNA to DNA. This proves, therefore, that understanding the molecular biology of a cell and how genes work could make an important difference in medicine molecular. Thus, genetics are more relevant to medicine than classical genetics, which is based only on observable results of reproductive
Bullying is a serious issue that can occur to various people of different age and background. It is considered a serious problem because of the long lasting health problems that comes with it. The many effects of bullying such as, depression and alcoholism can cause changes in our genes which can possibly be passed on to the future generations. In Sharon Moalem’s essay “Changing Our Genes: How Trauma, Bullying, and Royal Jelly Alter Our Genetic Destiny” he discussed about the effects of bullying on the victims and how it causes gene changes. It is important to know how to prevent bullying as the effects can influence a person mentally and genetically which can be passed on to future generations later on.
In 1990, the first great stride of genetics took place. This was called the Human Genome Project, a large-scale operation that was designed to understand the human genome (genetic structure). Since its commencement, there have been many leaps and bounds that have taken place. For certain genetic issues that we once knew nothing about, we no...
In the essay "Ethics in the New Genetics" by the Dalai Lama, the author states that before biogenetics may continue human beings must hold with them a "moral compass" that will protect all human beings from their fundamental characteristics to be taken away; the Dalai Lama hopes this will create more ethical decisions in the future. Similarly, in "Human Dignity" by Francis Fukuyama, the author examines the rise of human genetics and how it is going down a path that does not consider human essence, or in his words Factor X, as a legitimate attribute to all human beings as these biogenetics continue. The rise of biogenetics will create an unfair advantage to many, including farmers who will find that they must depend entirely on biotech companies
Trisomy 13 or Patau Syndrome” Trisomy 13 is a genetic disorder found in babies. It is also called Patau syndrome in honor of the physician who first described it, Krause Palau. Trisomy 13 is a genetic disorder in which there is three copies of chromosomes on Chromosome 13. Patau first described the syndrome and its involvement with trisomy in 1960. It is sometimes called Bartholin-Patau syndrome, named in part for Thomas Bartholin, a French physician who described an infant with the syndrome in 1656.
Francis S. Collins is a renowned geneticist who originally became Ph.D in Physical Chemistry at Yale University and later on, a Medical Doctor at University of North Carolina. As soon as he graduated he was offered a fellowship in Human Genetics at Yale University under the guidance of Sherman Weissman, currently Sterling Professor of Genetics. In the late 1980’s Collins became known in the field of Medical Genetics for his development of positional cloning, a technique that allows to locate a hereditary disease-causing gene by studying the inheritance pattern within a family. Working with his method researchers found the genes responsible for diseases like Cystic fibrosis, Huntington’s disease, Neurofibromatosis, Multiple Endocrine Neoplasia type one, and Hutchinson-Gilford Progeria Syndrome. In 1993 Dr. Collins succeeded Dr. James D. Watson as the director of the National Human Genome Research Institute (NHGRI), overseeing the role of the United States in the mapping of the human genome. In 2009 President Obama personally recommended Collins to lead the National Institute of Health (NIH) where he works until present day. Francis S. Collins is by no means a bragging individual, bits and pieces of his accomplishments are scattered throughout the book and he makes no big deal about it; instead he j...
[7] Klug, W., Cummings, M., Spencer, C., Palladino M. (2012) Concepts of Genetics: Tenth Edition. Pearson's Education, Inc.
Gene therapy is an experimental technique that allows doctors to insert a gene into a patient’s cell rather than using drugs or surgery. Gene therapy is a process of which defective or undesired genes in the body with “normal” genes. A vector is re-engineered to deliver the gene to a target cell. Then the gene is transferred to the cell’s nucleus and must be activated in order to function. The main focus of gene therapy is to replace a lost or improper gene with a new functional copy into a vector that is inserted into the subject’s genome by way of penetrating its DNA. Gene therapy can be done outside of the body known as ex vivo by way of taking cells form patients bone marrow or blood and then growing them in a laboratory. Thus the corrected copy of the gene is inserted into the cells before being put back into the body. Gene therapy can also be done in vivo which can be done directly to the patient’s body. The word gene therapy really defines the management of genetic information that is encased in the cells, however, in most recent procedures the available technology is closely related in adding new genetic information, and many researchers favor the term gene transfer rather than gene therapy to mirror the reason that the purpose of gene work cannot always be therapeutic.
Genetic screening techniques are coming of age and the controversy that surrounds them is growing by the minute. The definition of genetic screenings is as follows: a systematic search for persons with a specific genotype. These tests that look into the essence of humanity, will allow scientist and physicians the opportunity and ability to alter the human genotype for better or worse. Genetic advancements will bring controversy at every milestone. Genetic Screening usually takes place when an individu al or group shows risk for a disease or trait. Genetic testing can pinpoint a specific allelic interaction or multiple gene interactions, which may lead to a disorder. The common thread of life is DNA and DNA is the only major requirement for genetic sc reening. With knowledge of structure and function of DNA scientists can unlock the mysteries of life.
The diversity and the unity of life are equally meaningful and striking aspects of our Earth (Dobzhansky, 1973). Although an astounding 1.2 million species have already been identified, it is estimated that another 8.7 million are yet to be discovered and classified (Mora et al., 2011). By understanding what unifies us –our genes, our understanding of the organisms we share our planet with will continue to grow.
Epigenetics is the study of both heritable and non-heritable changes in gene translation, which do not stem from mutation. Epigenetic alterations to DNA may occur in several different ways; histone modification, DNA methylations, expression of microRNAs, and changes of the chromatin structure (Ntanasis-Stathopoulos et al). Depending on their presentation, they may be passed on to offspring. The exact mechanism of heritable epigenetic modification has not been discovered, but all of these alterations may have some impact on a wide range of disorders and have far reaching implications in the medical field. The study of epigenetics seeks to answer the age old question of whether nature or nurture is responsible for our phenotype, and it has arrived at the answer that in fact, both are. The discovery of epigenetic changes may lead us to cure many disorders, and even personality problems.
Gregor Mendel, born as Johann Mendel, is considered to be one of the most significant historic scientist of all time. He was an Austrian scientist and monk and is best known as the “Father of Modern Genetics.” He founded the science of genetics and discovered many things that dealt with heredity that still applies to our world today. He is remembered for paving the way for scientists and future generations to come. Unfortunately, Mendel’s work went unnoticed until 16 years after his death and 34 years after he published his research. Though Mendel lay covered in his grave, his work would eventually be uncovered. Although Mendel was not there to see it,
Genes are made of DNA – the code of life (Gene Therapy- The Great Debate!). The changes in genes may cause serious problems, which we called genetic disorder. In theory, the only method to cure genetic disorders is gene therapy, which basically means the replacement of genes in order to correct the loss or change in people’s DNA. Although gene therapy gives patients with genetic disorders a permanent cure, it is controversial because it has safety and efficacy problems, and raises ethical issues.
Most diseases are caused by a type of genetic component. Many of the diseases that have been caused by gene mutations are undiagnosed. These remain undiagnosed because the disease is so rare that the doctor does not know how to diagnose the patient. Many sy...
Retro-viruses and gene-specific medications could be used to alter a person’s genetic code, ridding a person of inherited maladies such as heart disease or diabetes. With the introduction of some, if not all, of these different methods of treating ailments, we could effectively wipe out a large amount of diseases that would otherwise be untreatable. Senior citizens would no longer have to suffer from maladies such as Alzheimer’s or other such illnesses related to age. With these procedures, a child can grow up never having to suffer from a learning disorder such as ADHD (Attention Deficit Hyper-activity Disorder) or even cases of mental retardation by eliminating or modifying the genes that are responsible for these and other problems.
...ary part in genotypes of potential interest that human geneticists breeders, as well as evolutionary geneticists are investigating. However, although we have the capability to unravel experiments that the founders of quantitative genetics would have never imagined, but their basic, un-computational machinery that they developed is most easily adaptable to the latest analyses that will be needed. We are far from ‘letting-go’ molecular biologists from the mathematical techniques/systems, because this age in respect to genomics has been forced into accepting gratitude due to the major importance of quantitative methods as opposed to the new molecular genetics. As geneticists tend to map molecular variation as well as genomic data, quantitative genetics will be moving to the front position because of its relevance in this age of rapid advancement in molecular genetics.