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Chemistry: Interpretation Of Chemistry

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Interpretation
• Referred to table 9
Paracetamol: 1.Amide: contains nitrogen and carbonyl so it’s hydrophilic.2. Hydroxyl: hydrophilic because of the presence of Oxygen that can H-bond with water.3.benzene ring: lipophilic because of non-polar hydrocarbon ring. 4. Methyl is lipophilic because of the nonpolar hydrocarbon group.
Aspirin: 1. Carboxylic acid: Oxygen that’s polar which can H-bond with water. 2. Ester: lipophilic because it is non polar although it has oxygen. 3. Benzene: lipophilic because of non-polar hydrocarbon ring.
Phenyl butazone 1. Carbonyl: hydrophilic because it’s polar and carries (partially positive and negative charge). 2. Alicyclic amine: has polar nitrogen that can H-bond with water, so it’s hydrophilic. 3. Benzene
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Carboxylic acid: hydrophilic, Oxygen that’s polar, form H-bond. 2. Alkyl: lipophilic, nonpolar hydrocarbons, can’t form H-bond. 3. Ether: although it has oxygen but it’s lipophilic. 4. Nitrogen: hydrophilic, polar, forms H-bond. 5. Benzene ring: lipophilic, nonpolar, can’t form H-bond.

• Referred to table 10:
Paracetamol there will be polarity of bonds since there is carbonyl group, OH, NH, the electronegativity will be toward the highest EN which is indicated with arrows on the molecule. Also the polarity of drug is partially since there are no charges. It seems like its partition happens more in lipid because of the presence many non-polar hydrocarbons than polar. It can be ionized in H2O since there is acidic functional groups (phenol and amide).
Aspirin: has a polarity of its bonds (Carboxylic acid and ester) and polarity of it is partially same as paracetamol. It seems like its partition happens more in lipid because of the presence many non-polar hydrocarbons than polar (just carboxylic acid). It’s susceptible for ionization to water to form (carboxylate inion).
Phenyl butazone Also same as Aspirin and paracetamol in its polarity, partition and susceptibility for ionization in water as it has (β-Dicarbonyl and alicyclic
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Also it will act with n-octanol because of the non-polar hydrocarbons. Aspirin has acidic functional group so it will also react with NaOH to form a salt (carboxylate ion) and it will interact with n-octanol also same as paracetamol in addition of presence of ester which lipophilic. Phenyl butazone contains acidic functional group (β-Dicarbonyl) which will interact with NaOH to give a salt (–OCO-). Also there will be interaction with HNO3 by tertiary amine which will give NH+. In n-octanol will be a reaction because of the hydrocarbon molecule. In Diclofenac there is interaction with NaOH by carboxylic acid to give a salt (carboxylate ion) and the aromatic amine with HNO3 to give (NH2+) also with n-octanol as there are hydrocarbons. Piroxicam there is interaction with NaOH with amide to give (N--C=O) and interaction with HNO3 with secondary amine (NH+) as well as interaction with n-octanol because of the hydrocarbons. Oxaprozin has carboxylic acid which react with NaOH to give (Carboxylate ion) and it has secondary amine which reacts with HNO3 to give (NH+) plus interaction with n-octanol as there are hydrocarbons and
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