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Celiac disease pathophysioloy
Celiac disease conclusion
Celiac disease conclusion
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Origin of the name/history of the disease
The name celiac comes from “coeliac” which is derived from the Greek Koilia, which means belly. The “coeliac flux” is an old expression meaning the same as diarrhea. The disease celiac is not just diarrhea though it just means that the disease pertains to the abdomen.
The celiac disease comes from early farmers and hunters. But because the wheat and grain of the crops and fields did not have high levels of gluten they were not exposed to the disease very often. Those who were infected would contract other diseases due to excessive defense. The disease did not hit hard until industrial quantities of gluten were introduced. The disease usually affects children at birth so you would think the disease would just die off. Wrong. The hinters and farmers developed an excessive defense to the disease. The defense would focus on the disease, which would make the person affected susceptible to other viruses. Also, breast-feeding preserves some children from the disease. The antibodies from the milk help fight the infections.
Loci of the gene/populations at risk/how common
Celiac has been mapped to the major histocompatibillity on chromosome 6.
Celiac mostly affects people of European descent and rarely affects blacks or Asians. It affects infants and can kill them at birth due to infections, malnutrition, and malabsorptio...
Celia, a Slave was a factual interpretation of one isolated incident that depicted common slave fear during the antebellum period of the United States. Melton A. McLaurin, the author, used this account of a young slave woman's struggle through the undeserved hardships of rape and injustice to explain to today's naive society a better depiction of what slavery could have been like. The story of Celia illustrates the root of racial problems Americans still face in their society. Although not nearly as extreme, they continue to live in a white-male dominated culture that looks down upon African-Americans, especially females. McLaurin looks at the views of the time, and speculates the probabilities of this pre - Civil War era, the values of which still pierce daily life in the United States.
Celiac Sprue also known as celiac disease is a chronic disease of the digestive tract that interferes with the digestion and absorption of nutrients from food. (Mohaumed Wehbi, MD) also Celiac Sprue is an immune reaction to eating gluten a protein found in wheat, barley and rye. Due to the intestinal damage and malabsorption celiac sprue can reduce the quality of life due to diarrhea, fatigue weight loss, bloating, and anemia. The lining of the intestine contains essential enzymes for the absorption and digestion, its destruction leads to malabsorption, a difficulty in absorption of food and essential nutrients.
Celiac Disease, also known as gluten intolerance, is an autoimmune disorder and it affects nearly 1 in every 133 people. A protein in wheat known as gliadin causes a person’s immune system to attack its own bowel and digestive system. This protein is also found in other grains such as rye, barley and oats. There are villi in the small intestine whose job is to absorb nutrients from the foods eaten. Since the body is attacking itself it causes the villi to atrophy and it erodes the nutrient absorbing villi, as it actually shortens and flattens the villi. Due to the affect of the gliadin proteins, it can cause irreversible damage to the lining of the small intestines and its villi. This condition seems to be genetic and can be passed down through generations. It was traditionally thought that this condition only affected People of European dissent, but recent studies show that it is also seen in people of Hispanic, Asian and African American dissent as well. There are blood tests that can be done to determine if one has celiac disease which is very helpful. If getting a blood test or an endoscopy done it is very important that gluten is still being consumed so as the see what affects it has on the body. Celiac disease can cause a myriad of other conditions like intestinal lymphoma; osteoporosis; anemia and it can stunt growth in children due to the fact that the body cannot absorb nutrients causing severe malabsorption of essential nutrients and vitamins.
Gluten is a protein found in common grains such as wheat, barley, and rye. Those affected with allergies to these foods (the most serious allergy being Celiac Disease) must follow a strict gluten-free diet in order to experience relief from their symptoms. Despite eliminating the ingestion of the allergen, gluten-free individuals begin to suffer from adverse side effects. In recent years, many Americans have begun to live an entirely gluten-free lifestyle with no medical necessity to do so. Many believe it to be a healthier diet, and even more believe it is an effective weight-loss tool. With this growing fad of adopting a gluten-free diet, under the false pretenses of varying health benefits, many Americans are exposing themselves to unnecessary health risks, over-priced and narrowly available foods, and an overall depletion of dietary needs.
The definition of Celiac disease is a common inflammatory disease of the small bowel that is precipitated by the consumption of foods that contain gluten. But Celiac disease is an autoimmune disease that the small intestine is hypersensitive to gluten, which leads to the difficulty of digesting food. This condition damages the lining of the small intestine and prevents it from absorbing nutrients from parts of food that are important for being healthy. The damage is due to a reaction to eating gluten, which is found in wheat, barley, and rye.
Hansen’s Disease also known as Leprosy dates back to at least 4000b.c. Evidence of the disease’s presents in ancient times was found on an Egyptian papyrus dating from around 1500bc. These earlier cultures believed it was a curse or punishment from the gods. During the middle ages, the afflicted wore special clothing and rang bells to alert the uninfected of their presence. The first known origin of this disease is Egypt from here Roman Crusaders contracted the disease and brought it back to Europe and from Europe to America.
Celiac disease is a multisystem disorder. It causes the body’s immune system to respond negatively to the protein in specific grains. "The immune system responds to these proteins because it thinks it is being attacked. It then builds antibodies to protect itself from these proteins and inturn those antibodies cause damage to the small intestines" (Bower).
For African Americans, there is a major relationship between unemployment and poor health, around one-third of their population is poor and that can cause illness due to a poor diet and bad living conditions. They also have most cost involved if healthcare is needed because they are less likely to have insurance coverage. Distrust in the healthcare system is another problem, because they believe that the care is inadequate or harmful. Also, having racism within healthcare systems can be very detrimental to the African Americans care. Babies in African American families are twice as likely to die than babies in white families. They have problems within their culture with cancer, sickle cell anemia and hypertension. For cancer, they have a 27% higher rate than whites do and for hypertension they are one-third more likely than whites to have it due genetics, poor diet and stress. Sickle cell anemia is worse for anyone with African American descent, one in twelve have the gene and around one in six-hundred actually develop the disease. This disease means that the blood cells will become elongated and pointed which will clog vessels, reducing oxygen flow, and could even cause organ
Sickle cell was first discovered by Dr. Ernest irons that was a hospital intern who look over a patients cell which seem to be different he called them “sickle cell shaped”. Sickle cell is know as a negro inherited diseases which is incorrect not only African Americans have this diseases. Many other races are effect by this diseases and regions all over the world such as India, Mediterranean countries, South American. In this case sickle disease work kind of like vaccination for malaria another diseases, this is the most common inherited disease in American. Anyone who has sickle trait and have a baby with someone who has the trait also can bring a baby into the world the world with SCD.
...n, the body is able to regenerate villi and gut physiology and functions should return to normality. However more research is being done on alternative treatments. Enzyme therapy is currently being studied, the treatment relies on enzymes such as gluten-specific endopeptidases and endoprotease reducing the antigenicity of gluten (Zingone, F., et al., 2010). tTg and inhibitors are also being investigated, although several gliadin epitopes have been shown to mount an immune response without being deaminated (Sollid, M.L., 2005). Another method that was under clinical trials depended on desensitising the body to gluten via a course of vaccines gradually increasing the concentration of gluten, (Zingone, F., et al., 2010) however none of the above methods have passed clinical trials so the only common treatment for coeliac disease remains leading a gluten free lifestyle.
Some of our population may be more at risk then others due to the ethnic background. This diseases is more prominent in some races more than others and studies have shown where the numbers increase or decrease depending on the race. Decedents of Africa, India, the Mediterranean, South and Central America and the Caribbean have a higher percentage of diagnoses. Countries who are exposed to the malaria parasite have the higher number of Sickle Cell cases. The percentage of African Americans with sickle cell is about 1 in 500 and a percentage 1 in 1,000 to 1,400 in Hispanic Americans. People of Caucasian race are less likely to have the diseases because of the history of the d...
Celiac disease is a fairly common disease but is not very well known. Celiac disease, or celiac sprue, is a digestive condition triggered by consumption of the protein gluten (Hill, Clinical manifestations and diagnosis of celiac disease in children, 2011). Gluten is a protein found in wheat, barley, rye, and oats. People with celiac disease who eat foods containing gluten experience an immune reaction in their small intestines, causing damage to the inner surface of the small intestine and an inability to absorb certain nutrients (Hill, Clinical manifestations and diagnosis of celiac disease in children, 2011).
We are seeing more wheat allergies than ever. There is a reason for this; the following will explain.
There is not an ethnic group that is not affected by heart disease. However, “the cardiovascular disease death rate among African Americans is 34 percent higher than for the overall U.S. population”. (“The Facts of Cardiovascular Disease”) African American women ages 50 and up are twice as likely as Caucasian women to be diagnosed with heart disease, and is more likely than Caucasian women to have a heart attack. A heart attack is the most common outcome of heart disease.
Food advertisements, supermarket displays, and restaurant menus increasingly highlight foods, particularly bread, as being gluten-free. Gluten consists of two proteins, gliadin and glutamine, which combine and help produce light and fluffy bread (Lord, 2012). Wheat is bred for its high gluten content which serves efficiently well for all bakers and chefs. Today, gluten is becoming a problem in society since allergic reactions to the protein have increased. Bread is a worldwide staple food and gluten is a predominant aspect within the dough mixture. Gluten free bread is basically fixed as it was thousands of years ago without the fermentation of yeast and the mixture of sourdough.