This paper will discuss bipolar disease and is also called manic-depressive illness. It will discuss the causes and prevalence of bipolar disease. It will also discuss the signs of symptoms of the disease. The diagnosis and treatment of bipolar will be discussed. Several studies are included in this paper. Causes of Bipolar Disorder and Prevalence The causes of bipolar disease vary between individuals. Available research indicates that genetic courses account for up to 90% of the reported cases (Fagiolini et al., 2013). It indicates there is a strong connection to hereditary components. Studies interested in genetics reveal the cause of this medical condition manifests in the candidate and chromosomal regions. The connection has currency because the regions are the main areas where the disease occurs. The disease tends to manifest in families, and research shows some people are likely to develop the disease more than others. For instance, children with a sibling or parent who suffers from bipolar disorder are likely to contract the disease more than those who from a family without a history of the disease. However, this does not mean that children from a family with the disease must develop it. Current technological advances in genetic research are improving the understanding of bipolar disease. The research uses a database to link genes that influence its cause with visible signs. There are also studies into diseases with similar symptoms, and this will help reveal a lot about the disease. The common symptoms scientists are concentrating their research on are schizophrenia and depression. The objective is to single out genetic differences that ultimately increase the person’s chances of suffering from the disease. Findings from ... ... middle of paper ... ..., Forgione, R., Maccari, M., Cuomo, A., Morana, B., Dell'osso, M., & ... Rossi, A. (2013). Prevalence, chronicity, burden and borders of bipolar disorder. Journal of Affective Disorders, 148, 161-169. Kanske, P., Heissler, J., Schönfelder, S., Forneck, J., & Wessa, M. (2013). Neural correlates of emotional distractibility in bipolar disorder patients, unaffected relatives, and individuals with hypomanic personality. American Journal of Psychiatry, 170, 1487-1496. Nery, F., Monkul, E.S., & Lafer, B. (2013). Gray matter abnormalities as brain structural vulnerability factors for bipolar disorder: A review of neuroimaging studies of individuals at high genetic risk for bipolar disorder. Australian & New Zealand Journal of Psychiatry, 47, 1124-1135. Phillips, M., & Kupfer, D. (2013). Bipolar disorder diagnosis: Challenges and future directions. Lancet, 381, 1663-1671.