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Effects of aging
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Case Introduction Joe Lombardy is an 82-year old retired carpenter who still does “odd jobs” for friends and neighbors. His wife has pleaded with him to relax, but he ignores her. Despite having chest pains (angina) and periods of confusion, Joe doesn’t trust doctors and has stubbornly refused to have a check-up. Recently, though, after several episodes of syncope (fainting) while he was hauling lumber, Joe grudgingly agreed to see a physician. On physical examination, the physician noted a murmur during systole (described as systolic ejection murmur). An ECG was consistent with left ventricular hypertrophy. His carotid pulse was weak and had a delayed upstroke. The physician ordered a cardiac catheterization, which showed a pressure gradient
In a normal human, the aortic valve contains three cusps which allow blood to quietly and smoothly pump out of the heart. People with congenital birth defects have more or less than three cusps (Mayo Clinic, 2014). As these patients become older, complications can arise due to the combination of structural deformity and calcium up build that occurs with age. The valve loses its ability to open completely because of the calcium which thickens the structure of the valve (Mayo Clinic, 2014). Lastly, the aftermath of rheumatic fever can affect the heart. As the human body attempts to fight off the fever, it indirectly attacks the valves of the heart. The valves become inflexible from the scarring that takes place (Cleveland Clinic,
The heart pumps blood from the left ventricle through the semilunar aortic valve and into the aorta. The narrowed aortic valve causes increased pressure in the left ventricle. Typically, muscles in the ventricles called papillary muscles contract during ventricular contraction, pushing blood through the valves. The left ventricle of a heart having aortic stenosis would have to work harder to pump blood through the narrower valve. The harder the muscles have to work, the thicker they become, explaining why left ventricular hypertrophy occurs in aortic stenosis (Klabunde, 2012, para.
The most likely diagnosis for the cardiac murmur in this horse is aortic insufficiency, as a result of degenerative changes to the aortic valve. In aortic insufficiency, the murmur heard is due to regurgitation through the defective aortic valve. Aortic insufficiency presents clinically with a holodiastolic decrescendo murmur, with maximal intensity over the aortic valve7, as is heard in this case. Holodiastolic means that the murmur is occurring between the end of S2 and the beginning of S1. Decrescendo refers to a murmur that gradually declines during diastole, as the pressure gradient between aorta and left ventricle drops, as a result of run-off into the systemic circulation and the ventricle. The murmur is often musical or honking in nature7. This is a common finding in older horses4, and the most common acquired valve lesion7, usually of little clinical significance.
Ebstein’s Anomaly is a rare congenital condition, present at birth, in which the tricuspid valve is malformed and the valve itself is not in the correct anatomic place (Mayo Clinic Staff). This anomaly affects the right side of the heart – the tricuspid valve is located too deep into the ventricle, causing a smaller and weaker right ventricle. The space above the decreased right ventricle is made up of atrial tissue and this can be referred to as right ventricle dysplasia or an atrialized right ventricle (Reynolds). Typically the tricuspid valve has three freely moving leaflets, but in Ebstein’s anomaly one or two of those leaflets get fused to the heart walls causing regurgitation. Since the heart does not work as efficiently in those who have this anomaly, the heart usually compensates and becomes enlarged. It...
The normal Mitral Valve controls blood flow between the upper (left atrium) and lower chamber (left ventricle) of the left side of the heart. The mitral valve allows blood to flow from the left atrium into the left ventricle, but not flow the other way. With each heartbeat, the atria contract and push blood into the ventricles. The flaps of the mitral and tricuspid valves open to let blood through. Then, the ventricles contract to pump the blood out of the heart. The flaps of the mitral and tricuspid valves close and form a tight seal that prevents blood from flowing back into the atria (nhlbi.nih.gov).
O’Rourke [13] describes the pulse wave shape as: “A sharp upstroke, straight rise to the first systolic peak, and near-exponential pressure decay in the late diastole.” Arteries are compliant structures, which buffer the pressure change resulting from the pumping action of the heart. The arteries function by expanding and absorbing energy during systole (contraction of the cardiac muscle) and release this energy by recoiling during diastole (relaxation of the cardiac muscle). This function produces a smooth pulse wave comprising a sharp rise and gradual decay of the wave as seen in Figure 5. As the arteries age, they become less compliant and do not buffer the pressure change to the full extent. This results in an increase in systolic pressure and a decrease in diastolic pressure.
“Hypoplastic left heart syndrome accounts for 9% of all critically ill newborns with congenital cardiac disease, causing the largest number of cardiac deaths in the first year of life.(2) ” HLHS is a severe heart defect that is present at birth. HLHS combines different defects that result in an underdeveloped left side of the heart. This syndrome is one of the most challenging and difficult to manage of all of the congenital heart defects. Multiple portions on the left side of the heart are affected including the left ventricle, the mitral and aortic valve, and the ascending aorta. These structures are greatly reduced in size, or completely nonexistent causing the functionality of the left heart to be reduced, or non-functional all together.
The thickening of the muscle cells do not necessarily have to change the size of the ventricles, but can narrow the blood vessels inside the heart. Hypertrophic cardiomyopathy can be grouped into two categories: obstructive HCM and non-obstructive HCM. With obstructive HCM, the septum (the wall that divides the left and right sides of the heart) becomes thickened and blocks the blood flow out of the left ventricle. Overall, HCM usually starts in the left ventricle. HCM can also cause blood to leak backward through the mitral valve causing even more problems. The walls of the ventricles can also become stiff since it cannot hold a normal amount of blood. This stiffening causes the ventricle to not relax and entirely fill with
The blood circulates through coronary arteries and then to smaller vessels into cardiac muscle (myocardium). The blood flow is influenced by aortic pressure, which increases in systole, and the pumping activity of the ventricles. When the ventricle contracts, in systole, the coronary vessels are compressed by the contracted myocardium and partly blocked by the open aortic valve therefore the blood flow through the myocardium stops.
Coronary heart disease is defined by the hardening of the epicardial coronary arteries. The buildup of plaque in the arteries slowly narrows the coronary artery lumen. In order to better understand the physiology of the disease, it is important to first know the basic anatomy of the human heart. The aorta, located in the superior region of the heart, branches off into two main coronary blood vessels, otherwise known as arteries. The arteries are located on the left and right side of the heart and span its surface. They subsequently branch off into smaller arteries which supply oxygen-rich blood to the entire heart (Texas Heart Institute, 2013). Therefore, the narrowing of these arteries due to plaque buildup significantly impairs blood flow throughout the heart.
Hypertrophic cardiomyopathy is an inherited disease that affects the cardiac muscle of the heart, causing the walls of the heart to thicken and become stiff. [1] On a cellular level, the sarcomere increase in size. As a result, the cardiac muscles become abnormally thick, making it difficult for the cells to contract and the heart to pump. A genetic mutation causes the myocytes to form chaotic intersecting bundles. A pathognomonic abnormality called myocardial fiber disarray. [2,12] How the hypertrophy is distributed throughout the heart is varied. Though, in most cases, the left ventricle is always affected. [3] The heart muscle can thicken in four different patterns. The most common being asymmetrical septal hypertrophy without obstruction. Here the intraventricular septum becomes thick, but the mitral valve is not affected. Asymmetrical septal hypertrophy with obstruction causes the mitral valve to touch the septal wall during contraction. (Left ventricle outflow tract obstruction.) The obstruction of the mitral valve allows for blood to slowly flow from the left ventricle back into the left atrium (Mitral regurgitation). Symmetrical hypertrophy is the thickening of the entire left ven...
The heart serves as a powerful function in the human body through two main jobs. It pumps oxygen-rich blood throughout the body and “blood vessels called coronary arteries that carry oxygenated blood straight into the heart muscle” (Katzenstein and Pinã, 2). There are four chambers and valves inside the heart that “help regulate the flow of blood as it travels through the heart’s chambers and out to the lungs and body” (Katzenstein Pinã, 2). Within the heart there is the upper chamber known as the atrium (atria) and the lower chamber known as the ventricles. “The atrium receive blood from the lu...
Most often the disease starts in the left ventricle, and then often spreads to both the atrium and right ventricle as well. Usually there will also be mitral and tricuspid regurgitation, due to the dilation of the annuli. This regurgitation will continue to make problems worse by adding excessive volume and pressure to the atria, which is what then causes them to dilate. Once the atria become dilated it often leads to atrial fibrillation. As the volume load increases the ventricles become more dilated and over time the myocytes become weakened and cannot contract as they should. As you might have guessed with the progressive myocyte degeneration, there is a reduction in cardiac output which then may present as signs of heart failure (Lily).
The heart is two sided and has four chambers and is mostly made up of muscle. The heart’s muscles are different from other muscles in the body because the heart’s muscles cannot become tired, so the muscle is always expanding and contacting. The heart usually beats between 60 and 100 beats per minute. In the right side of the heart, there is low pressure and its job is to send red blood cells. Blood enters the right heart through a chamber which is called right atrium. The right atrium is another word for entry room. Since the atrium is located above the right ventricle, a mixture of gravity and a squeeze pushes tricuspid valve into the right ventricle. The tricuspid is made up of three things that allow blood to travel from top to bottom in the heart but closes to prevent the blood from backing up in the right atrium.
Dr. Ally, a 49-year-old professor, has been diagnosed with essential hypertension 12 years ago and was on antihypertensive drugs. However, he did not take his medications last year because he was feeling just fine. In addition, he was very busy with work. Nevertheless, he felt tired after work and developed dyspnea while climbing the stairs. Recently, he had a bout of epistaxis (severe nose bleed) with dizziness and blurred vision. He went to the doctor for a check up. His blood pressure was 180/110, and the doctor found rales or crackles on his chest upon auscultation. The doctor ordered rest and asked him to start his medication again.
The heart is a pump with four chambers made of their own special muscle called cardiac muscle. Its interwoven muscle fibers enable the heart to contract or squeeze together automatically (Colombo 7). It’s about the same size of a fist and weighs some where around two hundred fifty to three hundred fifty grams (Marieb 432). The size of the heart depends on a person’s height and size. The heart wall is enclosed in three layers: superficial epicardium, middle epicardium, and deep epicardium. It is then enclosed in a double-walled sac called the Pericardium. The terms Systole and Diastole refer respectively and literally to the contraction and relaxation periods of heart activity (Marieb 432). While the doctor is taking a patient’s blood pressure, he listens for the contractions and relaxations of the heart. He also listens for them to make sure that they are going in a single rhythm, to make sure that there are no arrhythmias or complications. The heart muscle does not depend on the nervous system. If the nervous s...
Cardiovascular System: He does not experience any chest pain or palpitation. He does not have dyspnea or leg swelling.