Can Two Y Genes Replace the Y Chromosome in Mice?

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Can Two Y Genes Replace the Y chromosome in Mice?
The Y chromosome is important in any kind of reproduction because it determines if you’re going to be a male or female. The article claims that live mouse descendants can be created using germ cells from males with the Y chromosome to two genes. The SRY gene is called the sex determining region because it has instructions to make a transcription factor and develops as a male.
The Y chromosome gene is required to drive mouse sperm cells to cause mitosis in a cell allowing formation of haploid germ cells assisted in reproduction. The Y chromosome in animals are unused, scientists are thinking that they are involved in male reproduction. They investigated to see which genes are important for keeping sperm functions. They were able to do this by using ART they can take out several steps of normal human fertilization using attached, nonviable, immature sperm. They tested to see if infertile male mice lack the Y chromosome long arm and generate live offspring. When the structure of abnormal sperm are delivered in an immature egg cell in the ovary by a vitro fertilization procedure where a sperm is injected into an egg. The Y chromosome inside the mouse is reduced from 78 Mb to about 2 Mb and encodes seven genes and three gene families.
Animal testes are determined by the SRY and signals gonads to make differentiation. On the occasion with the addition of SRY, mice with one chromosome develop testis that are inhabited in any cells in the gonads. The cells have potential to increase in cell number by division and meiotic and post meiotic stages of spermatogenesis when they are not present. When scientists found an organism that was missing the Y gene, it gave rise to the idea that Eif2s3y was a gene that restored the ability to make sperm and spread it. In the X chromosome the males transgenic for Ei2s3y , the gonads showed to finish the meiotic prophase and the first meiotic division before the secondary spermatocytes. The scientists tested if the spermatid cells from the secondary spermatid cells were useful in ART and if other components of the Y chromosome increase in order to make functional gametes.
They observed if the mice with the Y gene was autosomally located in SRY and if the X chromosome was located in Eif2s3y. The mice had testes that are smaller than wild type XY in males but are populated with germ cells.

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