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biological influences of cocaine
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Recommended: biological influences of cocaine
Marisol Muneton
Professor Muller
BIOS 104
TA: Monica Farfan
The Biology of Cocaine Addiction Drugs are addictive substances that produce pleasant states such as euphoria or relieve distress. Drugs are classified into categories which include: depressants, stimulants, and hallucinogens. Depending on the type of drug and the way it is used, referring to if it is sniffed, swallowed, injected, or smoked depends the effect the addiction of that drug has on the body. Scientists such as Koob and Le Moal argue that drug addiction is caused by the dysregulation of the reward mechanism and subsequent allostasis which is the ability to achieve stability through change (Cami and Farre, 2003). Drug addiction produces adaptive changes in the central nervous
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According to Gawin (1991), cocaine addicts report that during binges everything including: nourishment, sleep, money, family, responsibilities, and survival, are all focused on cocaine. After long-term cocaine use, cocaine addicts can develop digestive disorders, weight loss, physical deterioration, deterioration of the nervous system, increase heart rate and blood pressure which can lead to heart attack and stroke (The Columbia Encyclopedia, 2013). Cocaine produces its effect of euphoria when an accumulation of dopamine is form in the synapse (NIDA, …show more content…
Cocaine addiction causes various changes to develop in the body of an addict especially most resulting in the brain. One of the effects of cocaine is that it blocks pain sensation and it stimulates the central nervous system causing changes in cell signaling and brain circuitry to develop. Some of the changes cocaine addiction causes in the brain is cognitive impairments which result in deficits in decision-making, abstract reasoning, and nonverbal problem solving. Cocaine also causes affective dysfunctions such as depressive disorders and attention deficit disorder. Other problems cocaine addicts can develop due to their cocaine addiction is digestive disorders, weight loss, and physical deterioration. The use of cocaine accelerates the heart rate and increases blood pressure which can led to an addict suffering a heart attack or stroke which can become
There are many biological factors that are involved with the addicted brain. "The addicted brain is distinctly different from the nonaddicted brain, as manifested by changes in brain metabolic activity, receptor availability, gene expression, and responsiveness to environmental cues." (2) In the brain, there are many changes that take place when drugs enter a person's blood stream. The pathway in the brain that the drugs take is first to the ventral tegmentum to the nucleus accumbens, and the drugs also go to the limbic system and the orbitofrontal cortex, which is called the mesolimbic reward system. The activation of this reward system seems to be the common element in what hooks drug users on drugs (2).
It is formed by the liver when cocaine and ethanol coexist in the blood. “Cocaethylene is the byproduct of concurrent consumption of alcohol and cocaine as metabolized by the liver”. “Cocaethylene increases the levels of serotonergic, noradrenergic, and dopaminergic neurotransmission in the brain by inhibiting the action of the serotonin transporter, norepinephrine transporter, and dopamine transporter”. It can increase depression making your response stronger to cocaine. You’re also prone to become aggressive with cocaethylene in your system. This mixture can increase heart attack and even lead to a sudden death. Cocaethylene stays in your system longer than cocaine and alcohol. It subjects into your heart and liver for a longer period of stress. Mixing alcohol and cocaine can be fatal up to 12 hours after you’ve taken
There are three different stages to addiction, the first being the adaptive stage. In this stage, the user is on top of his/her game. They feel as if they can function better while on the drug and are able to handle larger amounts. This is the person that can smoke crack before they go to work and will probably be more productive then most. “Cocaine is a powerfully addictive drug. Once having tried cocaine, an individual may have difficulty predicting or controlling the extent to which he or she will continu...
Lange, R. A., & Hillis, L. D. (2001). Cardiovascular complications of cocaine use. New England Journal of Medicine, 345(5), 351-358.
Drugs are substances that disturb this delicate balance, because they have “passkeys” that let them open certain “locks” located between the neurons. The brain automatically adjusts to these substances from outside the body by producing fewer of its own natural “keys”. Cocaine is type of drug that affects the dopamine is a neurotransmitter which is connected with emotions and noradrenalin is connected with alertness. Cocaine is considered as an illegal drug in most countries but some considered it as an legal drug. Although cocaine is an illegal drug earlier ancient people used to coonsider it as a medicine to treat many illness. Cocaine is absorbed in the dopamine and the...
The purpose of this research paper is to inform my audience of three primary sections based on biological aspect of the addictive substance cocaine, and its addictive properties. This will include the primary effects on the brain and other organs in the human body. The second section will confer, clinical issues along with medical treatment, future directions of treatment. The third section biological aspects of the addictive substance from a biblical perspective will be discussed. Some areas of interest include freedom and caution for Christian counselor’s based on the addictive substance used.
A study done by Puig and colleagues (2012) compared the effects of intermittent (once daily) and binge (three times a day) cocaine treatment for 1 and 14 days after the last cocaine injection on spontaneous locomotor activity and dopamine levels in the NAc in rats. The intermittent treatment led to a spontaneous increase in dopamine and in locomotor activity at the exact hour which rats were habituated to receive a cocaine injection (Puig, Noble & Benturquia, 2012). The binge treatment led to sensitization of locomotor effects of cocaine, associated to a dopamine release sensitization in the NAc (Puig, Noble & Benturquia, 2012). These results show the addictive nature of cocaine and the behavioural and sensitization effects it has on the animal, which can be related to the effects it can possibly have on humans (Puig, Noble & Benturquia,
The most commonly abused substances are Nicotine, Inhalants, Alcohol, Cocaine, Amphetamines, Prescription medications, Heroin, Ecstasy and Marijuana. 1a(National Institute on Drug Abuse, 2011) Initially, a person may find themselves using substances voluntarily and with confidence that they will be able to dictate their personal use. However, over the period of time that drug use is repeated, changes are taking place throughout the brain, whether it is functionally or structurally. Drugs contain chemicals that enter the communication system of the brain and disturb the way in which nerve cells would typically send, receive, and process information. The chemicals within these drugs will cause a disruption to the communication system by either imitating the brain’s natural chemical messengers or by over-stimulating the brains “reward system” by sending mass amounts of dopamine. As an individual prolongs his or her use of these substances, they may develop an addiction.
Cocaine (C17H21NO4) comes from the leaf of an Erythroxylon coca bush. It is a drug that effects the central nervous system. It causes feelings of euphoria, pleasure, increased energy and alertness. People under the influence of cocaine often do not feel the need for food or sleep. They also feel energetic and may talk a lot. However, depending on factors such as environment, dosage, and the manner in which the drug is taken, cocaine can have adverse effects such as violent, erratic behavior, dizziness, paranoia, insomnia, convulsions, and heart failure to name a few. Long- term effects of cocaine include, but are not limited to strokes, heart attacks, seizures, loss of memory, and decrease in learning capability (1).
Chronic addiction affects parts of the brain negatively, which leads to memory loss, poor decision-making, poor judgments, and immoral behaviors. These effects on the brain from drugs are long-lasting.
The use of cocaine in the United States has declined over the last twenty years while the use of crack has increased. Many people avoided the use of crack because of the harmful chemicals used in creating the drug. One of the reasons why crack became popular is because of not needing to inject the drug hence less risks of being infected by the AIDS virus. Carroll (2000) states cocaine is the most powerful stimulant of natural origin. Most users snort or inject the drug to enable a quicker “high.” Cocaine use brings on many health problems. Fatal complications occur from regular use, for example, liver damage, seizures, elevated blood pressure causing stroke, heart failure, or heart attack.
When using a drug like cocaine it causes the nerve cells to release an abnormal large amount of natural neurotransmitters and also prevents the normal recycling of brain chemicals which are needed to shut off the signal between neurons. Such disruption produces an amplified message that disrupts the normal communication patterns in the brain.
Cocaine travels through, the bloodstream whether you inject, smoke or snort it. It has effects on the Reward Pathway: the prefrontal cortex, VTA and the nucleus accumbens.
Abuse can cause countless medical problems to the body. A person who is addicted will continue to stimulate themselves regardless if they are aware of the negative chain reactions. Once addicted, it becomes difficult to stop due to how the body has become dependent. Health will be harmed the more a stimulant is used. Health effects include: cardiovascular disease, strokes, cancer, HIV/AIDS, hepatitis, lung disease, mental disease, birth defects. Mental health is what keeps a person in the right mind to make better decisions and have better control in life. Drugs have the ability to change mood and behavior. If drugs have affected the brain already, the desire increases which changes mental health. Some may not realize that they have been affected their health negatively. “A person who abuses drugs may not realize they have a problem until pronounced effects of drug abuse are seen, often physically. While drug abuse effects on the body vary depending on the drug used, all drug abuse negatively impacts one 's health (Addictions Community). Since drugs create many health issues, treatment is not a simple task. Treatments are hard to obtain and addictions often go
Many people that have smoked marijuana also try other drugs to get another type of high. Cocaine is a powerful stimulant that effects the brain directly. This powerful drug takes effect in very small doses by making a person feel more alert or energetic. Though people may think the drug helps them perform tasks faster with fewer complications, it also carries a list of effects. Some include constricted blood vessels, dilated pupils, high temperature, high heart rate, and bizarre behavior. Some...