Sadly, this world is majorly affected by disease. It tears families apart, ruins lives, and brings pain to the affected. This long list of life-destroying diseases includes systemic lupus erythematosus, or SLE. “[SLE] is a multisystemic, autoimmune disease of unknown etiology, which affects multiple organ systems, including the central nervous system, or CNS” (Milovancevic et al.). This disease will literally turn a person’s body against itself. It leads to a lot of pain in the victim. The optimistic side of this coin, however, tells us that many pharmacologists, over time, have created medications that can also nullify the effects of the symptoms. This includes a list of medications, such as antimalarial drugs, non-steroidal anti-inflammatory …show more content…
“Belimumab has been shown to suppress autoantibodies in people with lupus. It was approved in 2011 as the first drug created specifically for lupus in 50 years. Though it has shown to be helpful, further research is needed to determine its long-term effectiveness” (Ludham). Because they have not gotten more information on it, it is rarely used. However, from what we do know, it works well for SLE patients. Also, when they made research trials, they found that “In both trials the proportion of patients responding to therapy was significantly higher in the belimumab 10 mg/kg group than in the placebo group. There was no statically significant difference in response rate between patients receiving belimumab 1 mg/ kg and placebo” (Goldfinger and …show more content…
“No disease more dramatically illustrates the body's capacity to turn on itself than systemic lupus erythematosus (SLE). This is the prototypical example of the immune system gone awry, manufacturing antibodies that can injure and sometimes even destroy vital organs such as the kidneys, brain, and heart” (Goldfinger & Cotton). Numerous doctors have depended vigorously on treatment with cortisone-like steroids because they are guided by the idea that SLE's "protean indications" result from tissue aggravation created by a misrepresented insusceptible reaction. These medications regularly bring fast and emotional change in patients with exceptionally troubling indications (Goldfinger and Cotton). This information shows us that these fast acting drugs do wonders against SLE's symptoms by practically eliminating them. When these people develop emotional problems, such as depression, it can also stop them from having these thoughts of distress and sadness. Comparatively speaking, the effects of these drugs are practically nothing in comparison to the horrible symptoms of SLE.
In 2015, Doweiko’s research found that ”It is impossible for drugs to travel throughout the body without possible side effects“ (Doweiko, 2015, p.16). ”Prime affects versus side effects have been studied in order to find out how drugs harm but are contributing to healing“ (Doweiko, 2015, p. 16). The primary concern appears to be whether harm has to be the lesser concern in order to heal. Aspirin was used as an example of the healing component versus the side
The incidence of SLE is 7.6 cases per 100,000 with a prevalence of approximately 68 cases per 100,000 (Bernknopf, Rowley, & Bailey, 2011). It affects women more than men with a 9:1 ratio, and typically affects women of childbearing age (Patel, Fenves, & Colbert, 2012). The mean age of symptom onset was 29 years in the Euro Lupus Project that studied 1000 patients with SLE (“Systemic Lupus Erythematosus”, 2012). Children and older adults are also diagnosed with SLE but at a much lower rate, 8%-15% and 3%-18%, respectively (Arnaud, Mathian, Boddaert, & Amoura, 2010). Patients with ethnic backgrounds have a higher incidence rate with African Americans developing SLE 3-4 times more than Caucasians, unlike drug-induced lupus erythematosus (DILE) which has an equal male to female prevalence yet a higher disease severity in Caucasians (Bernknopf, Rowley, & Bailey, 2011).
Guided by fabulous results in preventing permanent damage from stroke and other injuries to the central nervous system in rats and other animals, researchers around the world have launched scores of trials in humans (12). However, many promising new therapies are sitting on the shelf because of a lack of money and other resources necessary to conduct large, lengthy, and expensive studies to conclusively show that a new drug or treatment really works in people. The requirement for safety and efficacy can be frustrating, especially for badly needed treatments that are very promising, but such caution is necessary.
If wellness equals homeostasis, then illness may be considered a loss or breakdown of homeostasis. Illness can be mild and require little or no intervention; sometimes the body will heal itself. At other times, though, illness can be a breakdown in the whole system. Sometimes, when something goes wrong, the brain loses the ability to fix itself or its extension, the body. To treat the illness, there are many drugs: some placebo-like and some are very potent, with enormous healing properties. Some drugs are homeopathic; they come from the earth in the form of herbs and have been used effectively to heal mild and annoying symptoms for hundreds of years. There are also beyond these, new and potent drugs that come from pharmaceutical laboratories. Some of these drugs have great healing power, but carry with them a double-edged sword, a healing edge and a destructive edge. It is one of these drugs, prednisone, that I wish to discuss in this paper. Physicians have prescribed prednisone to many of their patients who have life-threatening conditions. To illustrate, here is a quote from internationally known flutist and television commentator on the arts, Eugenia Zuckerman, who was diagnosed with an immunopathic lung disease.
Lupus comes in four different forms. They are Systemic Lupus Erythematosus, Discoid(cutaneous), Drug-induced Lupus, and Neonatal Lupus. “Systemic lupus is typically the most common form of lupus and generally considered more serious than the other three forms”(www.lupusmn.org). Systemic lupus can also be called SLE(www.lupusmn.org). Symptoms tend to show among patients and c...
Ginkgo Biloba, or maidenhair tree extract, has been used in Chinese medicine for centuries due to its pharmaceutical and medical properties. Ginkgo Biloba was introduced into the Western World in the 18th century. Nowadays, standardised Ginkgo Biloba extract EGb 761 is one of the most popular herbal supplements taken for potential memory improvement. This extract has many pharmacologically active components; the unique ingredients are terpene trilactones – ginkgolides A, B, C and bilobalide, which appear to be potentially antagonising inhibitory receptors in the brain. Ginkgo Biloba extract protects the neurons from oxidative damage and potentially prevents the progression of tissue degeneration. Numerous studies have been carried out to examine
Makover, M. & Zieve, D. (2011, February 14). Systemic Lupus Erythematosus. National Center for Biotechnology Information. Retrieved July 14, 2012, from http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001471/
In the early 20th century, depression therapeutic strategies ranged from invasive therapeutics like insulin coma therapy, chemical and electrical shock therapy to administration of some addictive chemicals like chloral hydrate, barbiturates, amphetamines and opiates (Lopez-Munoz & Alamo C, 2009). In 1950s, Ipronizide, which was previously used as anti-tuberculosis, was introduced as the first Mono-amino-oxidase inhibitor (MAOI) and the first antidepressant ever marketed. Then Imipramine was int...
It all started in 1964, when a small-time mail order business called Biba’s Postal Boutique advertised a pink gingham dress in the Daily Mirror that was similar to one worn by Brigitte Bardot. Over 4,000 orders were in the next day and went up to 17,000 in total. Behind this gingham mod dress was Polish-born designer, Barbara Hulanicki, who was able to open her first chocolate-box boutique in 1964 behind Kensington High Street after growing out of the mail order business. The Biba boutique only sold one type of dress in one size, but that didn’t stop young fashionistas from coming.
El Diario, which is mostly now known as El Diario/La Prensa is the longest publishing Spanish-language daily newspaper in the United States. This news organization has over 100 years of standing. It went through some economic issues at one point but somehow they pulled through, some even call it a miracle. Just by the title of the newspaper “El Diario” we can safely say that is for native Spanish speakers. This newspaper is specifically for Hispanics/Latinos to inform them of what’s occurring at the moment.
While current treaments, which include pharmaceuticals and surgery, do work in most cases there are numerous cases where they are dangerous or innefective. Some patients are unresponsive to pharmacological treatments or are unwilling to accept the risk of side effects. For example, under 55% of patients with epilepsy cease having seizures after treatment with anti-epileptic drugs (DeGiorgio and Krahl 743) and only 20-40% of patients with depression show significant improvement after one year(DeJongh and Haight 1)
As robots have become more of a reality and less of movie magic, (see Brian Gair’s robotics essay) they have been put to the test in many ways. Recently, the United States military has been funding companies to develop unmanned drones and unmanned vehicles that can travel to places we can’t, or don’t want to, go. They even have exoskeletons they allow soldiers to carry more without the added stress. Many companies, even ones you wouldn’t expect, are making these military robots. iRobot, the company known for its autonomous vacuum, makes four remote controlled vehicles used for situational awareness, bomb control, hazmat operations, and many other things. Boeing is working on unmanned helicopters and recon planes. Even the British Army is developing
As the leaders of hydroponic gardening, The GROFAX always makes sure to be on the cutting edge of new gardening innovations. The latest advancement is called Light Emitting Ceramic (LEC) technology, an uber-powerful indoor lighting source. Based in Aurora, CO, The GROFAX is proud to present its latest tool to indoor gardeners. The company savors the opportunity to keep improving the hydroponics experience for its customers.
Introduction Thesis Question What affects the total number of applicants to a Canadian University? Thesis Statement The ranking of different universities is an important aspect when considering the number of applicants the university has.
In 1964, George Solomon, a psychiatrist, noticed that rheumatoid arthritis worsened when people were depressed. He was fascinated by this connection, and began to investigate the impact of emotions on inflammation and immune function in general. His studies were the beginning of the new field of psychoneuroimmunology, which examines the relationships between the mind (psyche), bra...