Atrial Fibrillation with No Structural Heart Disease Should Always Undergo Catheter Ablation

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BACKGROUND

Approximately 10% to 30% of patients with atrial flibrillation (AF) do not present structural heart disease or have a comorbidity such as hypertension. Atrial fibrillation is the most frequent arrhythmia in daily practice that occurs under diverse situations and its treatment should be based on the different scenarios of presentation. Severe population-based studies have found that AF is associated with greater morbidity and mortality and worse quality of life. It is the leading cause of arrhythmia-related hospitalizations with an important impact on medical costs.

Radiofrequency catheter ablation steadily progresses as an option therapy to cure atrial fibrillation. The indications of catheter ablation are increasing due to a greater understanding of the physiopathological mechanisms, technological improvements and better outcomes. The Spanish registry reported that 1 out of 10 catheter ablations were indicated for AF. In the USA, AF is the most frequent condition undergoing catheter ablation in referral centers. How have we reached this point?

THE PROBLEM OF ANTIARRHYTHMIC TREATMENT

Drug therapy has proved to be ineffective to maintain sinus rhythm in patients with AF, with recurrence rates between 40% and 80%. Class I antiarrhythmic drugs are ideal for patients without structural heart disease or with mild conditions due to a lower proarrhythmic risk and better tolerance; yet, the efficacy if these agents is < 40%. In the AFFIRM and RACE studies, the group of patients without structural heart disease was small, and only 30% to 60% were still in sinus rhythm during follow-up. A meta-analysis comparing the efficacy of antiarrhythmic agents to maintain sinus rhythm showed that the proportion of patients in sinus r...

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