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Essay on the history of animal testing
Essay on the history of animal testing
Animal experimentation : a vital source
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Introduction
The heart is a complex yet well-studied organ that is key for life in all mammals. It is responsible for pumping blood around the body, transporting essential oxygen to all living cells whilst moving deoxygenated blood to the lungs. It is part of the autonomous nervous system, acting below the level of consciousness to keep the host well regulated and to maintain life. Failure to do so can lead to cardiac arrest, stroke and ventricular defibrillation. In 2008 cardiovascular diseases (CVDs) were responsible for 30% of all deaths, and CVDs are currently the number one cause of death globally . There are many proposed methods of reducing the risk of heart disease, with lifestyle and behaviour risk factors such as smoking, bad nutrition, alcohol and lack of physical activity noted as the main contributors . It is important to study the effects of physical activity, and the aim of this report is to study the affect of athletic training on the electrophysiology of the heart.
Throughout history animal testing has been conducted and plays a great role in our understanding of anatomy and bodily functions. Whilst ethically questionable, there is no denying the historical significance of animal experimentation. From third century BC animal dissections conducted by Aristotle , to Louis Pasteur’s work on sheep to discover vaccination , to modern day stem cell research, all have produced profound medical advances that have helped increase human understanding and saved innumerable lives. This report will use data collected from the athletic training of rats and mice to study pacing rate of the heart and arrhythmias. Rats and mice are commonly used due to their convenience: they are easily housed and maintained, are adaptable and...
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...by the values in the excel spreadsheet shown above.
Using the literature we find that the athletic heart rate should be around 80-90% of the control rate, so we can tailor the decrease in both INaCa and ICaL13 in order to observe this effect.
By observing the above plot we find that the peaks of two consecutive control cycles have x coordinates 1387.66 and 1600.38 respectively. This corresponds to a cycle length of 212.72ms, or 282.06bpm.
Using this data we therefore require the athletic mouse to have a heart rate of between 225 and 253bpm.
The above athletic plot, which has no decreasing INaCa or ICaL13, has consecutive peaks at coordinates 1362.28 and 1638.46. This corresponds to a cycle length of 276.18ms or 217bpm. We see that this is near to the target range. We will not change the multiplication factors for both INaCa and ICaL13 and observe the effects.
It increases during physical exercise to deliver extra oxygen to the tissues and to take away excess carbon dioxide. As mentioned at rest, the heart beats around 75 beats per minute but during exercise this could exceed to 200 times per minute. The SAN controls the heart rate. The rate increases or decreases when it receives information by two autonomic nerves that link the SAN and the cardiovascular centre in the medulla of the brain. The sympathetic or accelerator nerve speeds up the heart. The synapses at the end of this nerve secretes noradrenaline. A parasympathetic or decelerator nerve, a branch of the vagus nerve slows down the heart and the synapses at the end of this nerve secretes
(Simon and Levisohm 1987). Cardiovascular fitness helps to improve a healthy lifestyle. For this experiment the null hypothesis is that the intensity of the step rate test (High and Low) has no effect on the persons’ heart rate
The heart is an extraordinary structure that is the base of all human life. However, it similar to the uncomplicated functions of water pumps. As the heart beats, blood is distributed throughout the body using a network of blood vessels. The functions of the heart can be kept in regular and healthy conditions through exercise. Exercise has an effect on the blood that is circulating through the body. That circulating blood makes the heart desire more oxygen, causing the heart rate to increase rapidly to keep up with activity demand.
I predicted that the blackworms in higher caffeinated solutions would have higher pulse rates, because caffeine is known to increase blood pressure and heart rate. However as far as scientists know, invertebrates are not expected to have a strong response to caffeine like vertebrates do. Also, caffeine in low doses is known to lower pulse rate. The results do not support my hypothesis. The results show that when black worms are placed in caffeinated solutions, their pulse rates on average are lower than those placed in a solution with no caffeine. A possible flaw that may have occurred during experimentation is that the petri dishes were not properly cleansed, or that there were other properties in the water that influenced the outcome. To eliminate these flaws, I could have boiled the petri dishes and water to insure that there were no other properties to influence the data. Further experimentation should be performed with higher doses of caffeine to further insure that caffeine does in fact lower their pulse rate. The insufficient number of trials performed lead to less confidence in my conclusion that caffeine lowers the heart rate in
The study of cardio physiology was broken up into five distinct parts all centering on the cardiovascular system. The first lab was utilization of the electrocardiogram (ECG). This studied the electrical activities of the heart by placing electrodes on different parts of the skin. This results in a graph on calibrated paper of these activities. These graphs are useful in the diagnosis of heart disease and heart abnormalities. Alongside natural heart abnormalities are those induced by chemical substances. The electrocardiogram is useful in showing how these chemicals adjust the electrical impulses that it induces.
Results: The experiments required the starting, ending, and total times of each run number. To keep the units for time similar, seconds were used. An example of how to convert minutes to seconds is: 2 "minutes" x "60 seconds" /"1 minute" ="120" "seconds" (+ number of seconds past the minute mark)
State: The cardiac cycle is composed of five stages which each trigger the relaxation or contraction of the atria or ventricles and direction of blood flow.
This article discusses in detail, the various benefits of cardiovascular exercise for overall cardiovascular health.
to determine why athletes suffer sudden cardiac arrest, and although there have been a fair amount of conclusions, none have been clear and strong enough to determine why exactly they occ...
The purpose of this experiment was to gather data on how the amount of time spent active impacts the speed of heart rate in beats per minute. The hypothesis stated that if the amount of time active is lengthened then the speed of the heart rate is expected to rise because when one is active, the cells of the body are using the oxygen quickly. The heart then needs to speed up in order to maintain homeostasis by rapidly providing oxygen to the working cells. The hypothesis is accepted because the data collected supports the initial prediction. There is a relationship between the amount of time spent active and the speed of heart rate: as the amount of time spent active rose, the data displayed that the speed that the heart was beating at had also increased. This relationship is visible in the data since the average resting heart rate was 79 beats per minutes, while the results show that the average heart rate after taking part in 30 seconds of activity had risen to 165 beats per minute, which is a significantly larger amount of beats per minute compared to the resting heart rate. Furthermore, the average heart rates after 10 and 20 seconds of activity were 124 and 152 beats per minute, and both of which are higher than the original average resting heartbeat of 79.
AIM: - the aim of this experiment is to find out what the effects of exercise are on the heart rate. And to record these results in various formats. VARIABLES: - * Type of exercise * Duration of exercise * Intensity of exercise * Stage of respiration
The two major things that will help an athlete while measuring the cardiovascular drift are progression and hydration levels. The heart rate of an athlete working hard during a workout should be no more than their maximum heart rate which is found by, if you’re a female take 226-age, if you’re a male take 220-age. If while doing a workout the maximum heart rate is exceeded by too much it may be necessary to take a break or slow down greatly. This may also help with traking the hydration of an athlete. If an athlete stays hydrated their core temperature will stay regulated which means they won’t sweat as much, which also means the heart won’t be under as much stress while transporting the oxygenated blood throughout the body to the
Investigating the Effect of Exercise on the Heart Rate Introduction For it's size the heart has the huge capacity of pumping large amounts of blood, in the average adult's heart beats 60 to 100 times a minute, pumps between 70ml and 100ml of blood with each beat, circulates 5 to 6 litres of blood around the body per minute and about 13 litres of blood per minute during vigorous exercise. The heart will beat more then 2.5 billion times during an average lifetime. This investigation will be looking at the effect of exercise on the heart rate. Aim The aim of this investigation is to find out how exercise affects the heart rate, using research & experimenting on changes and increases in the heart rate using exercise. Research â— The heart The normal heart is a strong, hardworking pump made of muscle tissue.
Throughout centuries medical research has been conducted on animals. “Animals were used in early studies to discover how blood circulates through the body, the effect of anesthesia, and the relationship between bacteria and disease” (AMA 59). Experiments such as these seem to be outdated and actually are by today’s means, scientists now study commonly for three general purposes: (1) biomedical and behavioral research, (2) education, (3) drug and product testing (AMA 60). These three types of experiments allow scientists to gain vast amounts of knowledge about human b...
body has to work harder I think that the heart will then increase at a