Based on the 2003 DOH Philippine Health Statistics, disease of the heart (cardiovascular system) is included in the leading causes of mortality in the Philippines. Cardiovascular (also vascular) diseases are referred to by the general public as heart diseases which are imprecise such that it refers to the different kinds of diseases that may inflict the heart or blood vessels. Vascular diseases may cause (1) weakening of the walls of the blood vessels and this may lead to rupturing, (2) narrowing of the lumina of blood vessels and limiting of oxygen supply to a tissue, or (3) damaging of the endothelial lining and triggering intravascular thrombosis.
The most common and dangerous determinant of vascular disease is arteriosclerosis, literally meaning “hardening of the heart.” It is a general term for disorders whose similar effects to the arterial walls are its thickening and its loss of elasticity. Arteriosclerosis may occur as three types namely, Monckeberg’s medial calcific sclerosis, the calcification of the media of muscular arteries; arteriolosclerosis, the hyaline thickening of small arteries and arterioles; and the most common atherosclerosis, the formation of atheromas—a thickening of the arterial wall that is brought upon by cholesterol laden plaque and the amassing of scar tissue.
Of the three disorders, atherosclerosis (AS) is the most leading cause of death and morbidity in the Western hemisphere. It often targets the aorta and the coronary and cerebral systems, which in turn makes myocardial infracts (heart attack) and cerebral infracts (stroke) as two of its major consequences. AS is a sickness that progresses slowly; it is known to begin in childhood but complications usually appear only in middle-age when arteria...
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Cardiovascular disease (CVD) refers to the dysfunctional conditions of the heart, arteries, and veins that supply oxygen to vital life- sustaining areas of the body like the brain, the heart itself and other vital organs. Since the term cardiovascular disease refers to any dysfunction of the cardiovascular system there are many different diseases in the cardiovascular category, and many of these diseases are strongly intertwined. Ischemic Heart Disease is the medical idiom for the obstruction of blood flow to the heart. It is usually due largely in part to excess fat or plaque deposits that narrow the veins that provide oxygenated blood to the heart. This excess fat buildup and plaque are respectively known as arteriosclerosis and atherosclerosis. Hypertension is frequently a result of both arteriosclerosis and atherosclerosis, and can lead to more serious CVDs, such as angina attack (an acute and squeezing chest pain due to inefficient blood flow to the heart), and myocardial infarction( the sudden death of part of the heart muscle). A stroke is a CVD that occurs when there is in inadequate oxygen flow to the brain. An abnormally high or abnormally low heart rate because of the disruption of the natural electric impulses of the heart is called cardiac arrhythmia. Carditis and endocarditis, the infection and inflammation of the heart, can occur as a result of a weak immune system, liver problems, heart surgery, or an autoimmune disorder.
Coronary artery disease is a heart disease characterized by narrow arteries and restricted blood flow in arteries and is the major cause of morbidity and mortality globally.[1] According to WHO estimation, 6.8% in men and 5.3% in women are affected globally.[2-4] Cardiovascular disease account for 29% of all deaths in Canada; of all the cardiovascular death, 54% and 23% was due to ischemic heart disease and heart attack, respectively. The total costs for heart disease and stroke were more than $20.9 billion every year. [5,6] With more than 1 artery impacted, multivessel coronary artery disease is more complex and more likely accompanied by other comorbidities including diabetes or high blood pressure; multivessel coronary artery disease usually is more difficult to deal with, has worse prognosis and cost more compared with single coronary artery disease. [7]
Coronary artery disease (CAD) is the most common type of multifactorial chronic heart disease. It is a consequence of plaque buildup in coronary arteries. The arterial blood vessels, which begin out smooth and elastic become narrow and rigid, curtailing blood flow resulting in deprived of oxygen and nutrients to the heart [1].
Atherosclerosis is the buildup of fatty material called plaque along the walls of the arteries. This causes arteries to become narrowed and less flexible.
In today’s society, people are gaining medical knowledge at quite a fast pace. Treatments, cures, and vaccines for various diseases and disorders are being developed constantly, and yet, coronary disease remains the number one killer in the world.
Atherosclerosis is the culprit behind coronary heart disease (CHD) and stroke, which is the most common cause of death worldwide and in the United States10. Among the modifiable risk factors of CHD and stroke is the serum low density lipoprotein level (LDL)8, 11. Several randomized clinical trials have established that reducing the serum LDL level results in a reduction in the future risk of CHD and stroke in a linear relationship, in one study it was estimated that reducing the LDL by 1 % would reduce the risk by 1.7 %.1-4, 7, 9, 13
... J. (2009). Heart disease and stroke statistics--2010 updated: a report from the American Heart Association. Journal of the American Heart Association. doi:10.1161/CIRCULATIONAHA.109.192667
Atherosclerosis and its correlations date back over 3500 years, atherosclerotic lesions that dated from 1580 BC were found in Egyptian mummies. The disease portrayed alike pathological features in ancient times as it does today in modern society. The term Hippocrates was used around 460-377 BC as a description of unexpected death possibly due to acute myocardial infarction. In 300 BC the term Erasistratos was used to describe the major pathways of the cardiovascular system by an Egyptian physician.(1,2)
CHD is primarily due to atherosclerosis, which is the blockage of blood flow in the arteries due to the accumulation of fats, cholesterol, calcium and other substances found in the blood. Atherosclerosis takes place over many years, but when the blood flow becomes so limited due to the build up of plaque in the arteries, there becomes a serious problem. “When...
Coronary artery disease (CAD) is the number one killer in America, affecting more than 13 million people. CAD occurs when a fatty substance called plaque builds up in the coronary arteries. These arteries disperse oxygen-ric...
Wilson P. W. F. (2005) Molecular Mechanisms of Atherosclerosis Taylor and Francis Group: London Edited by Joseph Loscalzo
Cardiovascular disease is currently the nation’s leading non-communicable cause of morbidity and mortality. According to the American Heart Association, the most common form of cardiovascular disease is coronary artery disease, a condition in which the heart’s blood supply is reduced due to a narrowing of the coronary arteries. These arteries play a significant role in regulating the flow of oxygenated blood to the heart. As blood circulates through the arteries, it exerts a force against the vessel walls, known as blood pressure. To withstand this pressure, elastic fibers interspersed along the artery walls allow the arteries to expand and recoil. Abnormally high blood pressure, however, will cause these muscles to thicken as a result of tears in the damaged artery walls trapping particles that aggregate as plaque. Progressive build-up of plaque ultimately leads to a narrowing of the arteries, subsequently diminishing blood flow to the heart and other body organs. This cascade of events triggered by high blood pressure illustrates why hypertension is one of the most important risk factors for cardiovascular disease. Affecting 1 in every 3 adults in the United States alone, hypertension substantially raises the risk for heart disease in an affected individual who, most likely, does not show any signs or symptoms. In addition to the risks associated with this “silent killer,” comorbidities such as obesity, diabetes, and high cholesterol can drastically worsen health outcomes in hypertensive patients. Given the high prevalence and severe consequences of hypertension if undetected, researching this particular topic will increase our understanding of the causes of hypertension by identifying and narrowing down lead candidates for pot...
In United States, according to American Heart Association, Cardiovascular disease also called Heart Disease is number one cause of death in United States. There are different types of heart disease and one of them is Coronary Heart disease or Coronary Artery Disease/CAD. Coronary Artery disease or CAD is the most common type of heart disease for both men and women. It is unannounced and can be a silent killer. CAD is mostly can be from damaged or diseased arteries. Some conditions, habits, or traits may increase the risk of CAD and the more problem shows, th...
The most common, and most preventable, heart disease of all is coronary artery disease. This is caused when blockages develop in the blood vessels that provide oxygen-rich blood to the heart muscle. A more general term for any impairment of blood flow through the blood vessels is arteriosclerosis (Hale p.371). One of the most common symptoms is chest pain. When your heart muscle is not getting enough oxygen, it sends out a painful warning signal called angina pectoris(Hale p.372).
Atherosclerosis is a disease that occurs when arteries become blocked, inflamed, or hardened. As a result of this, blood cannot easily pass through the artery, and blood pressure increases. Many people suffer from atherosclerosis as they age, but young people can be affected by atherosclerosis also. There are many preventative steps that can be taken to decrease the risk of atherosclerosis; however, if atherosclerosis does develop in the arteries, medications can be given to help the individual receive adequate blood flow to important tissues. Atherosclerosis is a very serious condition that requires medical attention and a change in life style because it is a precursor to many dangerous and potentially fatal diseases.