Atherosclerosis and High Fad Diets

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Atherosclerosis

Atherosclerosis, which is a chronic inflammatory disease amongst the arteries of the human body, remains the principal cause of cardiovascular related disease (Gets, 2011). Atherosclerosis results from a complicated relationship between different factors such as lipid metabolism, blood coagulation elements, cytokines, hemodynamic stress, and behavioral risk factors. (Singla et al., 2011) The pathogenesis of atherosclerosis involves oxidative stress, endothelial dysfunction and chronic inflammation, which are initiated in response to high plasma lipid levels, especially Low Density Lipoproteins. (Yu et al., Getz., 2011) Atherosclerosis is a benefactor to the pathogenesis of myocardial and cerebral infarctions, gangrene and loss of function in the limbs, which results from an inconsistent inflammatory-fibro proliferative reactions to destruction of the endothelium and smooth muscle of the arterial walls (Morenoa et al., 1992). Researches have found that free radicals and reactive oxygen species have been suggested to be part of this pathophysiology (Calderon et al., 2008).

As atherosclerosis progresses over the decades, there seems to be lesion growth that are mostly facilitated by cellular adhesion molecules, which are expressed on the vascular endothelium and on circulating leukocytes in reaction to inflammatory stimuli; this is largely due to the recruitment of inflammatory cells from the circulation and their trans-endothelial movements. (Blankenberga et al., 2003) furthermore, there is now an agreement that atherosclerosis characterizes a state of heightened oxidative stress characterized by lipid and protein in the vascular wall (Singla et al., 2011). Over several decades Atherosclerotic plaque matures a...

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