Association of hepatitis G with unknown persistent elevated liver enzyme

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Introduction: Asymptomatic elevated liver enzyme is a common problem in clinic and will endamege liver in long-term (1). In a survey on 1959 blood donors in Iran, 5.1% affected by asymptomatic elevated liver enzymes, which was persistent in half of them and common diagnosis was non-alcoholic steato-hepatitis (NASH) in 88%, hepatitis C in 7.7%, alcoholic and drug related liver injury in 1.9% (2). Another study on about two thousand people in Golestan province- north of Iran, found out that the prevalence of persistent elevated liver enzyme was 3.1% with unknown etiology in about 80%, hepatitis B in 9.3%, hepatitis C in 6.2%, alcoholic liver and fatty liver disease in 4.6% and 2% , respectively (3). Hepatitis G Virus (HGV) is a RNA flavivirus transmitted mainly by parenteral rout. HGV RNA and HGV antibody (anti-E2) seropositivity in blood donors is about 1-4% and 3-14%, respectively (4). The mean prevalence of HGV in blood donors is 4.8% and is different in diverse world regions: 4.5% in Caucasians, 3.4% in Asians and 17.2% in Negros (5). Prevalence of HGV RNA on the people undergoing multiple blood transfusions such as thalassemia and hemodialysis is about 16% (6). It seems that Iran has the least prevalence of HGV as much as 1% in comparison to other Middle East countries such as Turkey (4.1%), Kuwait (24.6%), Jordan (9.8%) and Saudi Arabia (2%) (7-10). 75% of infected patients have normal liver enzyme with no symptom of hepatic disease; But it may cause acute and chronic hepatitis (11). In a study on 41 acute and 67 chronic hepatitis with unknown etiology in China, HGV RNA was detected in 6 (14.6%) and 12 (17.9%) patients, respectively (12). Another similar study on 55 acute unknown hepatitis patients revealed 29.1% HGV RNA sero... ... middle of paper ... ...UR, Schmidt WE. Prevalence of and risk factors for hepatitis G (HGV) infection in haemodialysis patients: a multicentre study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2002;17(2):271-5. 31. Campos AF, Tengan FM, Silva SA, Levi JE. Influence of hepatitis G virus (GB virus C) on the prognosis of HIV-infected women. International journal of STD & AIDS. 2011;22(4):209-13. 32. Komatsu H, Fujisawa T, Inui A, Sogo T, Morinishi Y, Miyagawa Y, et al. GBV-C/HGV infection in children with chronic hepatitis C. Journal of medical virology. 1999;59(2):154-9. 33. Yang JF, Dai CY, Chuang WL, Lin WY, Lin ZY, Chen SC, et al. Prevalence and clinical significance of HGV/GBV-C infection in patients with chronic hepatitis B or C. Japanese journal of infectious diseases. 2006;59(1):25-30.

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