Impaired cell death is a characteristic of cancer cells, determining their resistance to apoptotic signals, (Adams and Cory 2007, Hartman and Czyz 2013) which is one of the six essential alterations in cell biological capabilities acquired during the multistep development of human tumours (Hanahan and Weinberg 2011, Hartman and Czyz 2013) and remains critical in effective cancer treatment strategies (Adams and Cory 2007). Two major apoptotic paths have been defined; death receptor (extrinsic) and mitochondrial (intrinsic) pathway and they are usually switched on in a stimulus-dependent manner (Steel, Doherty et al. 2004, Adams and Cory 2007, Hartman and Czyz 2013).Such that extra-cellular death inducing signals via Fas receptors and various intra cellular signals result in activation of caspases (Du, Fang et al. 2000) (caspase 8 and 9) respectively. Intrinsic apoptotic pathway is widely implicated as a barrier to cancer pathogenesis than extrinsic apoptosis pathway (Hanahan and Weinberg 2011).
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2013). The importance of RAS in the development of hepatic fibrosis and the benefits of modulation of this system ACE gene expression has been shown in the previous studies (Shahid et al. 2013). Blockade of RAS could inhibit tumor growth. It is reported that CAP, an angiotensin converting enzyme blocker, was able to attenuate growth of murine model of colorectal cancer liver metastases (Wen et al.
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(Lindstrom, 2010) The increase in acetylated NPM1 is noted in cancer. (Lindstrom, 2010) Finding ways to de-acetylate NPM1 is cancer cells is a possible therapeutic strategy. (Lindstrom, 2010) During mitosis NPM1 binds GCN5 inhibits its acetylation of free and mono-nucelated histones. (Lindstrom, 2010) NPM1 also acts as a corepressor or coactivator of several transcription factors. (Lindstrom, 2010)
CA Cancer J Clin, 63, 11–30. doi:10.3322/caac.21166. Stepulak, A., Sifringer, M., Rzeski, W., Endesfelder, S., Gratopp, A., Pohl, E. E., … Ikonomidou, C. (2005). NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth. Proceedings of the National Academy of Sciences of the United States of America, 102, 15605–15610.