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Amyotrophic Lateral Sclerosis: Pathophysiology and Implications for Physical Therapy This work will provide a basic overview of the pathophysiology for amyotrophic lateral sclerosis (ALS) as well as the medical interventions used in treatment of the disease. Physical therapy interventions for ALS and therapeutic exercise recommendations are the major focus of this study, and will be discussed in greater detail in the later portion. Description Amyotrophic lateral sclerosis, or Lou Gehrig's disease as it is commonly called, is described by the ALS association (ALSA, 2010) as “a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord.” Amyotrophic is described by Porth and Matfin (2009) as muscle wasting or atrophy as a result of the death of lower motor neurons which is the most easily observed result of the disease process. Lateral sclerosis refers to the degradation of nervous tissue in the lateral columns of the spinal cord due to scarring. ALS presents with the following signs and symptoms (S&S). Early stages involve muscle weakness, involuntary movements, spasticity, twitching and cramping; these usually begin in the distal extremities (Lescher, 2011). Progressive S&S include atrophy and paralysis of muscles of the limbs, trunk, and face as well as fatigue, dysarthria, dysphagia, and hyperreflexia (i.e. highly sensitive gag reflex and positive Babinski reflex). As a result of weakness and paralysis in the muscles of the face and throat, feeding and respiration are affected. Most people with ALS are eventually dependent on mechanical ventilation. Demographics ALS most commonly affects people between the ages of 40 and 70; the average age is 55, most are Caucasian (93%) and it is 2... ... middle of paper ... ...451-461. Available from http://iospress.metapress.com/content/j8p10mxtu180u036/ Lui, A. J., & Byl, N. N. (2009). A systematic review of the effect of moderate intensity exercise on function and disease progression in amyotrophic lateral sclerosis. Journal of Neurologic Physical Therapy, 33(2), 68-87. doi: 10.1097/NPT.0b013e31819912d0 Pflumm, M. (2012). Exercise: Stretching the limits of ALS care. Retrieved from ALS Therapy Development Institute website: http://blogs.als.net/post/Exercise-does-a-body-good-But-what-about-pALS.aspx Porth, C. M., & Matfin, G. (2009). Pathophysiology: Concepts of altered health states (8th ed.). Philadelphia, PA: Wolters Kluwer Health-Lippincott Williams & Wilkins. University of Pittsburgh, Center for ALS Research. (2013). Occupational and physical therapy. Retrieved from http://www.alsresearchcenter.pitt.edu/patients/pt_ot_therapy.php
Sacket et al, cited in, Duncan, E,A,S, (2006) Foundtions for practice in Occupational Therapy, 4th edition, Elsevier Ltd.
Rietberg MB, Brooks D, Uitdehaag BMJ, Kwakkel G. Exercise therapy for multiple sclerosis (Review). Cochrane Database Syst Rev. 2004;3.
Amyotrophic Lateral Sclerosis, commonly referred to as ALS, is a disease that can alter the daily life of a human in monumental and unending ways. In one of her articles about ALS, Caroline Ingre (2015) states that the disease is a “fatal neurodegenerative disorder” and further supports this by noting how the disease is marked by the degeneration in motor neurons in the brain, brainstem, and spinal cord (p. 181). This basically means that
According to ALS Association (2016, para. 1), “Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in Amyotrophic Lateral Sclerosis eventually leads to their demise.” When our motor neurons die, our brain can no longer control our muscle movement. The survival time for a person living with Amyotrophic Lateral Sclerosis is up to ten years because eventually a person’s body will shut down completely. According to the Mayo Clinic (2016, para. 2), “As the disease advances and nerve cells are destroyed, your muscles progressively weaken. This eventually affects chewing, swallowing, speaking and breathing.” This disease is very scary to live with because you eventually die from
Lou Gehrig's disease is often referred to as Amyotrophic lateral sclerosis (ALS), this is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Motor neurons come from the brain to the spinal cord and from the spinal cord to the muscles throughout the entire body. The progressive degeneration of the motor neurons in ALS would eventually leads to their death. When the motor neurons die, the ability of the brain to initiate and control muscle movement is also lost. With voluntary muscle action progressively affected, for this reason patients in the later stages of the disease may become totally paralyzed (Choi, 1988).
Alzheimer’s disease was first defined in 1906 by a German psychiatrist, Alois Alzheimer. Alzheimer's disease is the most common form of dementia. It is a progressive brain disorder in which the nerve cells in the brain gradually die off. It is estimated that 26 million people world-wide are afflicted by Alzheimer’s and of those, approximately 4.5 million live in the United States. It is said to be the seventh leading cause of death in the USA and the fifth leading cause of death for those over age 65. Seventeen percent of women and ten percent of men age 55 and older can expect to develop Alzheimer’s (apa.org, 2009). Researchers report that this disease is more prevalent in African Americans and Hispanics than in whites (Crandell, Crandell, and Zanden, 2009, p. 578).
Salgado, S., Williams, N., Kotian, R., & Salgado, M. (2013). An Evidence-Based Exercise Regimen for Patients with Mild to Moderate Parkinson's Disease. Brain Sciences (2076-3425), 3(1), 87-100.
Amyotrophic lateral sclerosis, or ALS, is a degenerative disease affecting the human nervous system. It is a deadly disease that cripples and kills its victims due to a breakdown in the body’s motor neurons. Motor neurons are nerve cells in the brainstem and spinal cord that control muscle contractions. In ALS, these neurons deteriorate to a point that all movement, including breathing, halts. Muscle weakness first develops in the muscles of body parts distant from the brain, such as the hands, and subsequently spreads through other muscle groups closer to the brain. Such early symptoms as this, however, can hardly be noticed.
Imagine if you loss control of your body but your mind stayed unaffected. You would be a prisoner in your own body, all leading up to your death sentence. That is the sad fate for the people diagnosed with Amyotrophic lateral sclerosis (ALS). “Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder was first described by Ran in 1850. This description was then expanded in 1873 by Charcot, who emphasized the involvement of the corticospinal tracts. In the United States, ALS is often referred to as Lou Gehrig's disease, after the famous ball player who was stricken by the disease in the midst of his career. (Yale School of Medicine, 2014)” In this paper will go through the definition, the process, the signs, the risk factors, etiology, and discus the known people that have suffered with this terminal disease.
National Institute on Deafness and Other Communication Disorders. (November 2002). Retrieved October 17, 2004, from http://www.nidcd.nih.gov/health/hearing/coch.asp
Occupational therapy was based off of psychology; we evolved from treating mentally ill patients with isolation as an efficient treatment plan. We must never forget we are known to be “the art and science of helping people do the day-to-day activities that are important and meaningful to their health and well being through engagement in valued occupations” (Crepeau, Cohn, & Schell, 2008). To other professional disciplines this article explains the difference between each of us, yet can also express our relation to one another. The basic goal of all therapeutic disciplines is to better our clients life, through physical, speech or occupational therapy. Every discipline targets different goals, may it be body mechanics, reducing a stutter or buttoning a shirt, at the end of the day our clients well being may it be through science, art or both is all that matters. To the occupational therapy field this article means progress for what we do. Reading this article today in the year 2015 did not seem like old information to me, it is still relevant, I am proud that our field is not only evolving with contemporary time but it is also maintaining its
Amyotrophic lateral sclerosis (ASL), Lou Gehrig’s disease, a brutal, unforgiving illness of the neurological system with no known cure.
Porth, C. (2009). Pathophysiology: Concepts of Altered Health States (8th ed.). Philadelphia: Lippincott, Williams & Wilkins.
This is a neurodegenerative disease, meaning it results in progressive loss or death of neurons. It often starts off with effecting simple motor skills like writing and holding things, after a few months usually patients start losing the ability to walk, talk, or move any of their limbs. Although the brain trauma is what causes it, ALS has little-no-effect on the brain. This fatal disease is typically diagnosed around age 60 and most patients are given about 3-5 years to live after being diagnosed. It has been found that 10% of cases are shown as genetic. It was brought to attention that athletes were beginning to get diagnosed with ALS at a younger age than most. After extensive research in the early 2000’s, Brain Analyst, Dr. Mckee ran tests and finally came to the conclusion that the toxic proteins in the brains of ALS patients were coming from repeated blows to the head. It was then made evident why so many athletes in contact sports such as football, soccer, boxing, etc… were being diagnosed at such a young age and more frequently than
Uhland, Vicky. “The Picture of Health.” Momentum 6.3 (2013): 42-45. Academic Search Premier. Web. 20 Mar. 2014.