Amitriptyline: Tricyclic Antidepressant (T

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1. Amitriptyline is classified as a tricyclic antidepressant (TCA) used for the management of depression and other psychiatric disorders. This drug prevents reuptake of serotonin and norepinephrine at the presynaptic nerve terminals. Amitriptyline toxicity causes hypotension by blockage of the alpha-receptors peripherally. Toxicity can also cause central and peripheral anticholinergic effects, which includes symptoms of dry mucus membranes, dilated pupils, urinary retention, and absent bowel sounds. 2. An overdose of amitriptyline can cause blockage of the cardiac sodium channels, which are responsible for rapid depolarization during phase 0 of the action potential. These fast response action potential are found in atrial myocytes, ventricular

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