Alzheimer's Disease

Alzheimer’s disease is a slowly progressive, degenerative disorder of the brain that eventually results in abnormal brain function and death. The disease was first described in 1907 by a German physician, Dr. Alois Alzheimer(1864-1915). In the neurological autopsy on the brain of a 56-year-old woman Auguste D., of Frankfurt, who died after several years of progressive mental deterioration marked by increasing confusion and memory loss. Taking advantage of a then-new staining technique, he noticed an odd disorganization of the nerve cells in her cerebral cortex, the part of the brain responsible for reasoning and memory. The cells were bunched up like a rope tied in knots. He termed the strange nerve bundles neurofibrillary tangles. He also noted an unexpected accumulation of cellular debris around the affected nerves, which he termed senile plaques. In a medical journal article published in 1905, Alzheimer speculated that the nerve tangles and plaques were responsible for the women’s dementia.

Alzheimer’s disease is a disorder marked by a gradual decline in brain function that gets worse with time. It used to be assumed that this change was a normal part of aging that we called senility. Some people develop this condition when they are as young as 40 years of age. However, the disease is most common in persons over the age of 65. It is estimated that approximately 10 percent of persons over 65 years of age may have Alzheimer’s disease and that in persons over the age of 85, up to 50 percent may be affected. Alzheimer’s disease is not a normal part of the aging process. It is not contagious, and it is not known how it can be prevented. While the physical changes in the brain are very similar among different people the behavioral and psychological symptoms that result are complex and may differ from person to person(Kawas, 80). These symptoms lead to a form of dementia which is the loss of mental skills and abilities, including self-care capabilities. As Alzheimer’s disease progresses, these losses will result in total dependency for even the simplest activities(Erickson, 149).

Alzheimer’s disease usually comprises of three stages. The first being the onset stage. The symptoms of the onset stage often appear very gradually. There may be some minimum memory loss, particularly of recent events. The individual may experience difficulty in finding the right words to use during casual conversations. Work performance may begin to deteriorate and changes in behavior may start to become obvious.