Advantages And Disadvantages Of Allografts

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According to the Centers for Disease Control (CDC), Traumatic Brain Injury (TBI) is the world’s leading major cause of death.[1] It was said that the peripheral nervous system (PNS) and central nervous system (CNS) injuries may result to temporary or permanent impairments of cognitive and physical functions.[1, 2] To repair these injuries is to rely on the ability to gain back the appropriate neuronal connectivity.[3] These functional impairments can be repaired with neural transplantation, such as allografts and autografts.[4] Autografts consist of tissue repair using autologous cell/tissue for transplantation.[5] However, the flaw for autografts is the loss of function at the donor site leading to multiple surgeries.[6] On top that, the materials can be limited and at times when patient still suffer from neuroma pain.[6] Allografts on the other hand, utilise tissue from the same species but different subject.[5] However, the disadvantages for allografts are the risk of disease transfer and the potential to cause an immune reaction.[5] Due to the disadvantages faced by autografts and allografts, biodegradable three- dimensional nanofibrous scaffold in tissue engineering (TE) is introduced for tissue regeneration as they show promising regenerative outcomes.[2, 6, 7]. To promote neural regeneration, the nanofibrous scaffold is design to provide the mechanical support for the transplanted cells, guidance cues for neurites and for the delivery of biomolecules.[2] Besides that, to promote neural regeneration the nanofibrous scaffolds shows 2 features that is well suited for CNS tissue engineering applications.[8] These two features are the highly porous structure, morphology and architecture of the fibre.[8] The highly porous struct... ... middle of paper ... ...trospinning are able to control the morphology and fibre diameter of the fibre providing the support that is able to mimic the ECM.[16] The following dissertation will discuss on the fabrication of electrospun PCL nanofibre for tissue regeneration. This is to address the limitation faced by current TE scaffold. As there are insufficient focus on the production of PCL nanofibres with surface morphology and even fibre diameters for the use for tissue regeneration. On top of that, biopolymer such as PCL has the ability to degrade over time and still produce the porous structure desired by the nanofibre.[17] Hence, to control the fabrication of PCL nanofibre, the effects of the electrospun parameters is studied in the following dissertation. On top of that, the dissertation will investigate the fabrication of electrospun PCL nanofibre scaffolds for tissue regeneration.

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