Adiponectin: a Novel Indicator of Malnutrition and Inflammation in Hemodialysis Patients.

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Objective Protein-Energy malnutrition (PEM) and inflammation are common and overlapping conditions in hemodialysis patients which are associated with increased risk of morbidity and mortality. Adiponectin is an adipocytokine which is exclusively produced by adipose tissue. Few studies in hemodialysis patients have demonstrated that serum levels of adiponectin were significantly higher in malnourished patients compared to well-nourished ones. The aim of this study was to further elucidate the association between serum adiponectin levels and the nutritional–inflammation status of hemodialysis patients.

Design. Observational comparative study.

Setting and Subjects 80 patients on stable hemodialysis at Shiraz Nemazee Hospital for at least three months three times weekly without any acute illness. The patients were divided into two groups of well-nourished (n=23) and malnourished (n=57) based on their nutritional status.

Main outcome measure Serum levels of adiponectin, interleukin-6 (IL-6), albumin, cholesterol, triglyceride, high-sensitive C-reactive protein, urea, creatinine, transferrin, homocysteine, ferritin, parathyroid hormone, as well as body mass index, the subjective global assessment (SGA) score, and the malnutrition–inflammation score (MIS) were measured in all patients; these values were compared between well-nourished and malnourished patients. The correlations of these variables with serum levels of adiponectin were determined as well.

Results Except the serum levels of adiponectin and IL-6 which were significantly higher in the malnourished patients compared to the well-nourished ones (40.7 ± 29.3 ng/mL versus 26.35 ± 16.8 ng/mL, p = 0.037 and 58.95 ± 106.7 pg/mL versus 50.78±145.61 pg/mL, p= 0.029, respective...

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...Girard V, Alonso M, Lindholm B. In hemodialysis, adiponectin, and pro-brain natriuretic peptide levels may be subjected to variations in body mass index. Hemodial Int2011 Oct;15(4):477-84.

Dear Editors,

Please consider our article entitled “Adiponectin: a Novel Indicator of Malnutrition and Inflammation in Hemodialysis Patients.” for publication in your prestigious journal. In this study, we evaluated the association between serum adiponectin levels and malnutrition and inflammation in hemodialysis patients. The results of our study confirm the contribution of adiponectin to inflammation and malnutrition in hemodialysis patients.

On behalf of all authors, I declare that we are responsible for the accuracy of data and all matters contained in the paper including accuracy of references.

Sincerely,

Maryam Ekramzadeh, PhD

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