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Patho of acute renal failure
Acute kidney failure case study
Acute renal failure pathology
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Acute Renal Failure
Acute renal failure is a common complication of critically ill clients. This disease contributes to the already increased morbidity of these clients, increasing the risk of mortality by 2-15 times, depending upon associated factors. Mortality rates are at 4 million per year in the United States. Rapid treatment of these clients significantly increases the chance of survival. Rapid treatment is dependent upon rapid diagnosis. Acute renal failure is a group of syndromes characterized by sudden, usually reversible decrease or total loss of renal function, resulting in decreased urinary output and increased serum urea and creatinine levels, which are typically excreted by the kidneys (Kunzendorf 2010).
Loss of renal function may be a result of a lack of blood flow to the kidneys, damage within the kidney, or problems occurring after the formation of urine, in the ureters or bladder. These 3 sites allow for many possible complications which lead to acute kidney failure (Vann 2011). A lack of blood flow may be caused by hypovolemia, heart attack or heart disease, infection, liver failure, overuse of nephrotoxic medication such as NSAID’s or aspirin, anaphylaxis or burns. Damage within the kidneys may be caused by blood clots or impaired blood flow within the kidney which may be due to cholesterol deposits, scleroderma or vasculitis, glomerulonephritis, hemolytic uremic syndrome, infection or sepsis, certain medication such as chemotherapy drugs, antibiotics or dyes used for imaging studies (Mayo 2012). The most common intrarenal cause is acute tubular necrosis, which is the death of the kidney’s filtration cells due to a lack of oxygen (Vann 2011). Urinary obstruction is the cause of renal failu...
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Hudson, K. (2007). Acute Renal Failure. Retrieved from
http://dynamicnursingeducation.com/class.php?class_id=131&pid=18
Kunzendorf, U. (2010). Novel Aspects of Pharmacological Therapies for Acute Renal Failure. Drugs, 70(9), 1099-1114. Retrieved Nov 30 2013 from CINAHL.
Mayo Clinic. (2012). Acute Kidney Failure. Retrieved from
http://www.mayoclinic.com/health/kidney-failure/DS00280
University of Kansas Medical Center. (2012). Pathophysiology of Acute Renal Failure. Retrieved from
http://classes.kumc.edu/cahe/respcared/cybercas/dialysis/portpath.html
Vann, M. (2011). Acute Renal Failure. Retrieved from
http://www.med.nyu.edu/content?chunkIID=234981
Yaklin, K. (2011). Acute Kidney Injury: An Overview of Pathophysiology and Treatments. Retrieved from
http://www.austincc.edu/nursmods/rrc/rrc_lev4/rhsg_2432/documents/CNEAcuteKidneyInjury.pdf
There are two types of glomerulonephritis—acute renal failure (ARF) and chronic kidney disease (CKD). The ACF form generally develops suddenly as a result of an infection or illness, such as, group A streptococci bacteria, hepatitis, or in diseases such as lupus or HIV (Mathias, 2013). This type may require dialysis to replace renal function while it lasts, however, kidney function usually returns after the primary illness is treated. Many acute patients will not have any other complications as no permanent damage is done. Whereas CKD is found in a person that has had glomerulonephritis for months to years in some cases and may be asymptomatic until the kidney has become irreversibly damaged. ARF can evolve to become chronic if the glomeruli do not respond to
Shearer, F., Lang, C.C., and Struthers, A.D. (September 11, 2013) Renin–angiotensin–aldosterone system inhibitors in heart failure. Clin. Pharmacol. Ther. 10.1038/clpt.2013.135
Renal and hepatic function tests include creatinine test, blood urea nitrogen (BUN) test, alkaline phosphatase (ALP) test, bilirubin test, and others. Urinalysis includes urine osmolality tests and urine culture tests. The sooner one’s sepsis is diagnosed and managed, the better the chances are one has to survive. There are three identifiable stages of sepsis. The three stages are, in order, sepsis, severe sepsis, and septic shock. The stage of sepsis is achieved when an infection enters the bloodstream and enacts inflammatory responses throughout the body. This stage is not as life threatening as the next two stages but should be assessed and treated for as soon as possible. The stage of severe sepsis is achieved when an infection disrupts the flow of blood to the brain or renal organs resulting towards organ failure. There can be an occurrence of gangrene in the arms, legs, fingers, and toes exhibiting tissue death caused by blood clots. If treatment is not given quickly in this stage then septic shock is bound to occur. The stage of septic shock is achieved when the overall blood pressure drops drastically leading to respiratory, cardiac, or organ failure and likely death This stage demands
Pathophysiology There are three different stages of acute renal failure; prerenal, intrarenal, and post renal. Prerenal failure is a result from an illness or injury that causes obstruction of blood flow to the kidneys, called hypoperfusion. Hypotension, hypervolemia and inadequate cardiac output are all examples that could cause prerenal failure. According to Lippincott Williams and Wilkins (2009), “prerenal azotemia, excess nitrogenous waste products in the blood, account for 40% to 80% of all cases of acute renal failure” (p. 307). Intrarenal is when there is direct damage to the kidney tissue by either inflammations, drugs, infections or a reduction in the blood supply to the kidney. Post renal is when there is an obstruction of the urine flow. Causes of obstruction could be enlarged prostate gland, kidney stones, bladder tumor or injury. There are four phases of acute renal failure; onset, oliguria, diuresis and recovery. The onset phase can last hours or up to days. The BUN and creatinine levels may start to increas...
(5)Tolwani AJ,Gampbell RC,Stofan BS,Lai KR,Oster RA,Wille KM.Standard versus high dose CVVHDF for ICU-related acute renal failure.J Am soc Nephrol 2008;19:1233-8
As a result of this there is insufficient blood flow to the kidneys. Secondly, Acute intrinsic kidney failure occurs when there is direct trauma to the kidneys. This usually occurs when taking a sever hit to the body near the kidneys. Other factors could be toxin overload and ischemia, lack of oxygen to the kidneys caused by renal blood vessel obstruction, shock, sever bleeding or inflammation. Chronic pre-renal kidney failure is a third type of kidney failure occurring when there is a long-term lack of blood flow to the kidneys. This type of kidney failure usually causes the kidneys to shrink and lose their function. Then, Chronic intrinsic kidney failure occurs by direct trauma to the kidneys due to severe bleeding or lack of oxygen. Lastly chronic post-renal kidney failure is a result of blockage of the urinary tract prevention urination and causing pressure eventually leading to kidney
Sepsis is a severe medical condition that is caused by an infection in the body that travels to the blood stream. This infection has extremely high death rates and can be linked to most admissions in the intensive care unit. There is a series of events that happens once an infection occurs in the body. These events are preventable if caught early on in this cascade.
United States Renal Data System (USRDS). (2008). Annual data report: Incidence and prevalence. Retrieved July 8, 2009, from http://www.usrds.org/2008/pdf/V2-02-2008.pdf
This article is for people whose kidneys fail to work. This condition is called end-stage renal disease (ESRD).
Overall, for an acute kidney failure patient the hope is that they are able to have complete recovery and be free of complications and electrolyte and fluid imbalances by the end of treatment. Though, this is not true for most, because many AKI patients have co-existing morbidities and need treatment until the end of life. As nurses all we can do is give the best care that we know how and make our patients feel as comfortable as possible while they’re under our care.
Kidney damage can occur from hypertension which causes blood vessels in the kidneys to shrink and harden; infections travelling though the bloodstream; long-term and uncontrolled diabetes, and genetically inherited kidney problems. (Edith Cowan University, 2001-2004)
Cats who have acute kidney failure due to trauma or poisoning will often recover once the primary issue that caused the kidney failure is addressed. This may include surgery, medications, fluid therapy or blood transplants. If the kidneys don 't respond after the primary issue is treated, other courses of treatment will need to occur in order to address the kidney failure.
Kidney Function Introduction and definition of terms: The kidneys are the main organs in the urinary system. They filter waste products out of blood from the renal artery. These are then excreted. Useful solutes are reabsorbed into the blood. They also have a major homeostatic role in the body, and help to control the water content (osmoregulation) and pH of the blood.
The kidneys are a bean-shaped organ in the human body and they have different functions and are of vital importance for it. The kidneys are the pair of organs, which are able to regulate the reabsorption of ions such as potassium, sodium and calcium, which are fundamental substances for the cell. Furthermore, they are involved in the reabsorption of nutrients in the bloodstream and they can regulate the acidity of the blood. Besides the regulation of the fluids and ions, the kidneys are also responsible for the regulation of many different hormones that are involved in homeostasis and metabolism. Because of their importance in the regulation of substances in the body, when the kidneys stop working properly all the body is influenced by that creating disequilibrium in the maintenance of homeostasi...
Chronic Kidney Disease. Mayo Foundation for Medical Education and Research, 2014. Web. 20 May 2014.