Atypical or second generation antipsychotics (SGAs) are generally replacing first generation antipsychotics (FGAs) in the treatment of schizophrenia. This report reviews the literature to report on the risk/benefit differences between the two groups. In terms of efficacy the literature is mixed; some studies report that the two groups have similar efficacy across the three main schizophrenic symptoms, or at least no clear advantage with SGAs. Others show that atypicals may have a minor advantage over conventional antipsychotics in reducing positive symptoms. Differences do appear when their side effects are compared. SGAs have a clear advantage with extrapyramidal symptoms (EPS) over FGAs which is a key factor in classifying a drug as a typical or atypical. This includes a much reduced rate or observed tardive dyskinesia (TD) in patients. Most atypicals have also no effect on QT and sudden death. However most SGAs can induce significant weight gain and both groups have been implicated with diabetes. Atypicals are a varied group with differing characteristics, but are generally an improvement on FGAs in schizophrenia treatment.________________________________________
Introduction
Schizophrenia is the combination of severe psychosis with the impairment of social and cognitive abilities, which affects approximately 0.5-1% of the population. The controversies associated with the treatment of treatment of schizophrenia are numerous. One debate is over the merits of FGAs and SGAs, which have been argued for decades now. The demand for a definitively better option is huge. Schizophrenia is a life-long disease so even a moderate increase in efficacy would have a substantial effect on quality of life, though this also means side effects m...
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My patient Gerald –according to the video- is diagnosed with a textbook case schizophrenia. He exhibits paranoid thinking and his speech is disorganized, his thoughts are loosely connected, and he has formed delusions, he exhibits mood disturbances, and exhibits disordered behaviors (Schizophrenia: Gerald, Part 1). The goal for Gerald is multi-factorial; first, it is important to place into context that Gerald’s schizophrenia is refractory to pharmacological management. Due to Gerald’s complex presentation of multiple symptoms, the goal for the interaction is improved m...
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Mental illnesses are diseases that plague a being’s mind and corrupts one’s thoughts and feelings. Schizophrenia is one of the many disastrous illnesses that consume one’s life, is known as a real disease that deserves much attention. Experts believe that what causes the illness is a defect in the gene’s of the brain, and little signs of schizophrenia are shown until about one’s early adult years. Some effects of schizophrenia can either be negative or positive, but even if the effects could be either one, people should still be aware that there is something puzzling and alarming happening in the mind of a schizophrenic patient.
Schizophrenia is a deteriorating progressive disease, consequently, it is resistant to treatment for the individual suffering schizophrenia. (Catts & O’Toole, 2016). In most cases the individuals suffering from schizophrenia, are resistive to treatment, in most cases, individuals suffering from schizophrenia, and are resistive in taking antipsychotics. (Catts & O’Toole, 2016). Jeremy doesn’t see himself as a “schizophrenic”, he states that “he’s happy naturally”, and often he’s observed playing the guitar and doing painting in his room. Weekly, he has an intramuscular medication to treat his disorder, crediting the support of his wife. It is indicated that the morality rate, in patients suffering from schizophrenia is higher, despite the considerable resources available, in Australia. New data show that in 20 countries, including Australia, only 13.5% meet the recovery criteria, which means that 1or 2 patients in every 100, will meet this criteria per year. (Catts & O’Toole, 2016). This means that there’s a decline in providing support and services to individuals like Jeremy suffering from a mental illness such as Schizophrenia. Many individuals become severely ill before they realise they need medical treatment, and when receiving treatment it is usually short-term. (Nielssen, McGorry, Castle & Galletly, 2017). The RANZCP guidelines highlights that
Schizophrenia is one of the most misdiagnosed illnesses of all time. Its characteristics of identification – hallucinations, delusions, lack of body control, etc. - often cause it to be identified as depression or post-traumatic stress disorder (PTSD). Doctors and scientists still debate the major cause of schizophrenia. Through research it is carefully observed that genetic factors play a larger role in the cause of schizophrenia than environmental factors.
According to Gamble and Brennan (2000), the effectiveness of medication for schizophrenia to relieve patients from psychotic symptoms is limited. Although patients have adequate medication, some received little or no benefit from it and almost half of them still experience psychotic symptoms. They are also more likely to suffer relapse (Gamble and Brennan, 2000). Furthermore, Valmaggia, et al. (2005) found that 50% of patients who fully adhere to anti-psychotic medication regimes still have ongoing positi...
If the United States had unlimited funds, the appropriate response to such a high number of mentally ill Americans should naturally be to provide universal coverage that doesn’t discriminate between healthcare and mental healthcare. The United States doesn’t have unlimited funds to provide universal healthcare at this point, but the country does have the ability to stop coverage discrimination. A quarter of the 15.7 million Americans who received mental health care listed themselves as the main payer for the services, according to one survey that looked at those services from 2005 to 2009. 3 Separate research from the same agency found 45 percent of those not receiving mental health care listing cost as a barrier.3 President Obama and the advisors who helped construct The Affordable Care Act recognized the problem that confronts the mentally ill. Mental healthcare had to be more affordable and different measures had to be taken to help patients recover. Although The Affordable Care Act doesn’t provide mentally ill patients will universal coverage, the act has made substantial changes to the options available to them.
Classical antipsychotic treatments are commonly used to treat schizophrenic patients with major positive symptoms of schizophrenia, such as Thorazine, Haldol, and Stelazine (Gleitman et al., 2011). Antipsychotic treatments are usually administered with a variety of psychosocial treatments including social skills training, vocational rehabilitation, supported employment, family therapy, or individual therapy (Barlow & Durand, 2014). This is to reduce relapse and help the patient improve their skills in deficits and comply in consuming the
According to the recent research from Biochemical theories states that schizophrenia is caused by neurotransmitter dopamine in the prefrontal cortex which is a chemical that transmits signals in the brain. On the other hand the researchers states that psychological factors is cognitive function such as learning, m...
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...ected over another because it has less chance of damaging a diseased liver, worsening a heart condition, or affecting a patient’s high blood pressure. For all the benefits that anti-psychotic drugs provide, clearly they are far from ideal. Some patients will show marked improvement with drugs, while others might be helped only a little, if at all. Ideally, drugs soon will be developed to treat successfully the whole range os schizophrenia symptoms. Roughly one third of schizophrenic patients make a complete recovery and have no further recurrence, one third have recurrent episodes of the illness, and one third deteriorate into chronic schizophrenia with severe disability (Kass, 206).
New drugs are being made in order to address the issue of undesirable and intolerable side effects of conventional antipsychotic drugs. Works Cited Comer, R. J. & Co., Inc. (2011). Fundamentals of abnormal psychology. New York, NY. Worth Publishers Nasar, S. (2001).A beautiful mind: the life of mathematical genius and Nobel laureate John Nash.