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Diclofenac sodium is commonly used asanti-inflammatory and anti-pyretic agent. Frequent administration and undesired side effects, fluctuations of plasma concentrations of the drug may lead to patient incompliance, and hence, improper therapy. Therefore, the present work will be devoted to formulate the drug using Moringa Oleifera gum to explore its use as sustained release (SR) polymer.The goal of a sustained release dosage form is to maintain therapeutic blood or tissue levels of the drug for an extended and specified period of time. This is generally accomplished by attempting to obtain "zero-order" release from the dosage form.Moringa gum (MG) was separated and isolated from raw gum of Moringa OleiferaLinn and employed in formulating tablets of Diclofenac sodium at concentrations of 5, 10, 15, 20, 30, 40 % w/w. The tablets were prepared by wet granulation technique and were subjected to hardness, friability, weight variation, drug content uniformity and dissolution studies. The physical properties were found to be satisfactory for all the formulae. Dissolution data was used for calculation of zero order, first order, higuchi, korsmeyer, peppas plots. The drug release involved diffusion mechanisms.The in vitrostudy revealed that theoptimized formulation has shown 96% drug release following zero ordercompared to the marketed formulation (voltren) which followed first order release and has shown 95.6% drug release. The developed sustained release tablet can perform therapeutically better than a conventional tablet. Keywords: Diclofenac sodium;Moringa Oleifera Gum;Sustained release; Tablets; Zero order Oral drug delivery is one of the widely employed routesfor administration of the drugs that have been explored for t... ... middle of paper ... ...ease tablets, but the use of plant polymers has more added advantages like natural in origin, biocompatible, biodegradable, low cost,free from side effects, etc. so in the present study moringa gum was used as a polymer in preparation of SR tablets of Diclofenac Sodium. Moringa gum is a natural polymer derived from bark ofMoringa oleifera (Family: Moringaceae).Moringa gum is easily collected without any complicated procedure and it is also available in huge amount. The bark of this plant contains a white crystallinealkaloid, two resins, an organic acid, mucilage and ash.The moringa gum contains about galactose 41.5%,arabinose 26.9%,xylose 25.9%, rhamnose 5.6% and trace amount of uronic acid. Studies have shown that Moringa gum finds its use as both medicinal and additive properties. The swelling property of polymer was helpful for sustained release of the drug[3].
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