Emerging infectious diseases and the increase in incidence of drug resistance among pathogenic bacteria it is the researchers’ responsibility to search for new antimicrobials. Despite the increased knowledge of microbial pathogenesis and application of modern therapeutics, the morbidity and mortality associated with the microbial infections remains high. Therefore, there is a demand in discovering novel strategies and to identify new antimicrobial agents to develop the next generation of drugs or agents to control microbial infections. Fungi produce a wide range of secondary metabolites with high therapeutic value as antibiotics, cytotoxic substances, insecticides, compounds that promote or inhibit growth, and are gaining importance for their biotechnological applications. The research work deals to synthesize secondary metabolites from Penicillium species culture and to evaluate the bio-effect of bioactive compounds against selected bacteria pathogens.
Keywords: Antimicrobial Activity; Bioactive compounds; Identification; Penicillium species
The increased use of antibacterial an...
S.marcescens is viable enough to flourish on standard media with the production of a pigment, which characteristically ranges from a red to a dark pink shade. Through its pathway of synthesis, Prodigiosin is formed as an alkaloid secondary metabolite with a linear tripyrrole chemical structure (figure 1), (Samrot et al, 2011). Secondary metabolites are natural products and also by-products of metabolism.(Vaishnav and Demain, 2011).
Ever since the discovery of antibiotics in the 1920’s, treating bacterial infections in humans, and animals alike, has emerged as a revolutionary possibility. Antibiotics are drugs that are naturally produced by bacteria or fungus to defend against other bacteria via death or inhibiting reproduction (1). Since their detection, antibiotics have been diversified into many different forms and classes which are arranged by mode of action. Glycopeptides are a class of antibiotics which are composed of glycolsylated cyclic or polycyclic nonribosomal peptides that inhibit cell wall synthesis in susceptible bacteria (2). However, it was soon discovered that the use of these antibiotic drugs would lead to antibiotic resistance. This paper will discuss the history, function, and resistance associated with vancomycin, a glycopeptide antibiotic.
The natural components of antibiotics have been used as local remedies long before humans understood the reasons why these sometimes-radical treatments worked. Penicillin became the first manufactured antibiotic after physician Alexander Fleming published articles regarding this bacteria-disabling mold in 1928. Come 1932, penicillin was commonly used to treat infected war injuries, saving the lives of unnumbered soldiers (Lewis). Since then, penicillin has b...
Stewart, Philip S, (2001) states that antibiotics are elements that are used to kill, or hinder the multiplication and growth of organisms. Especially, these antibiotics are meant to control fungi and bacteria. In this case, the antibiotics that are used in killing bacteria are referred to as bactericidal, and the ones that are used to prevent the multiplication process are bacteriostatic. The primary microbes for antibiotics are bacteria and fungi. These microorganisms are crucial to facilitate the secretion of substances that kill harmful bacteria which confer competition for the limited available nutrients (Southern, P. J., &Berg, 1981).
Antibiotics basically refer to chemical substances that can inhibit and destroy the growth of microorganisms (Gottileb,1976; Katz and Demain,1977). Antibiotic term was first used in 1942 by Selman Waksman to describe any substance produced by a microorganism which interfere with the growth of other microorganism (SA Waksman, 1947). Each antibiotic is produced by a relatively limited number of species and is inherited from specific set of genes. These are the products of secondary metabolism which can be produced commercially by microbial fermentation after active growth has declined. These compounds are generally synthesized in stationary phase especially idiophase (unbalanced growth phase) so these are sometimes called as idiolites(walker, 1974). Their formation is highly influenced not only by the growth conditions but also by the composition of the culture medium.
The Egyptians were experts at trading, importing and exporting goods with various countries. Due to its geographical location, Ancient Egypt was able to obtain great success through trading and commerce. The Nile River provided many inlets into the Red Sea and Mediterranean Sea, these passages allowed for greater opportunities for trading and communication with neighboring countries. The use of vessels proved to be a great resource in securing the Egyptian economy with its vast amount of riches, providing the main mode of transportation for trade and travel. This paper will examine Ancient Egypt’s relation with the Nile River and the trade and commerce that secured it as one of the greatest nations in history (Baines, 2002).
Penicillins are a group of antibiotics used to treat a large range of bacterial infections. They are derived from Penicillium fungi and can be taken orally or via injection and treat the following conditions:
Compounding all of these solutions, the pharmaceutical industry needs to conduct extensive research on developing new antibiotics for various pathogenic bacteria by studying the bacterial structure. This will help scientists to formulate ways of counteracting the functions of the various constituents of bacteria.
Infectious diseases represent an important cause of morbidity and mortality among the general population, particularly in developing countries. Therefore, pharmaceutical companies have been motivated to develop new antimicrobial drugs in recent years, especially due to the constant emergence of microorganisms resistant to conventional antimicrobials (Silva et al., 2010).
Penicillin, derived from the mold Penicillium, is the first antibiotic to successfully treat bacterial infections on humans. It was accidentally discovered by scientist, Alexander Fleming. While Fleming was growing Staphylococcus, a serious and often deadly infection, in a dish, he noticed the bacteria had stopped growing after a mold found its way
In this exercise, Penicillium was utilized, a common, safe, mold. Certain species of Penicillium will spoil fruits, vegetables, grains, and grasses. Other species will ripen various chesses. Still, other species are used in the production of antibiotics. The species of Penicillium, italicum is provided for the lab because of its pronounced hyphae. Penicillium italicum, along with Penicillium digitatum attack citrus fruits post-harvest. In this experiment, the effect of Penicillium italicum on two types of citrus fruits and one non-citrus fruits were tested.
Since antibiotics, such as penicillin, became widely available in the 1940s, they have been called miracle drugs. They have been able to eliminate bacteria without significantly harming the other cells of the host. Now with each passing year, bacteria that are immune to antibiotics have become more and more common. This turn of events presents us with an alarming problem. Strains of bacteria that are resistant to all prescribed antibiotics are beginning to appear. As a result, diseases such as tuberculosis and penicillin-resistant gonorrhea are reemerging on a worldwide scale (1).
Penicillin was the first antibiotic discovered in 1928 by Alexander Fleming. He observed a set of culture dishes that were used to grow staphylococcus. He saw that a mould was growing around the staphylococcus this mould produced a bacteria-free ring around itself. Two other scientists, Florey and Chain, developed penicillin into an effective drug. Penicillin was tested for over 20 years on both humans and animals. In 1941 scientists noticed that even low doses of penicillin that were produced prevented many deadl...
Discovery and Development of Penicillin. (2014, April 4). Retrieved from American Chemical Society International Historic Chemical Landmarks: https://www.acs.org/content/acs/en/education/whatischemistry/landmarks/flemingpenicillin.html
Synthetic drugs used now a day are being the cornerstone for the prevention and treatment of almost all diseases and conditions, becoming a new topic of concern for their detrimental side effects, broad-spectrum non-specific action along with their association with morbidity and mortality [1]. Evolution of multidrug resistant microbial strains and other human pathogen are also contributing in a quest for alternatives of these synthetics [2]. Cost, doses, route of administration, availability of synthetic drugs are also serving as limiting factors.