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Tilmicosin (TIL) is a long-acting macrolide antibiotic approved for treatment of cattle with Bovine Respiratory Disease. However, it has been reported to induce cardiac toxicity when taken in an overdose. Our experimental objective was to evaluate the protective effects of Mirazid® (myrrh) and or vitamin C; Ascorbic acid (AA) against TIL-induced cardiotoxicity in mice. Fifty six male Swiss albino mice were divided into seven groups, each of eight. The 1st served as a control group and injected with saline. The 2nd and 3rd groups were orally given MRZ and AA at a dose of 100 and 20 mg/kg bw for five days respectively. The 4th group received a single dose of TIL (75 mg/kg, SC). The 5th and 6th groups were given MRZ and AA at the same dose regimen used for the 2nd and 3rd groups before TIL administration at the same dose and regimen used for the 4th group. The 7th group was given both MRZ and AA one hour before TIL administration. Our results indicated that TIL-treated animals revealed a significant increase in serum cardiac damage biomarkers as well as cardiac lipid peroxidation but caused an inhibition in antioxidant biomarkers. Each of MRZ and AA tends to normalize the elevated serum levels of lactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase-MB (CK-MB). Furthermore, it reduced TIL-induced lipid peroxidation and oxidative stress parameters. Both MRZ and AA induced a synergistic cardioprotective effect when given together. It could be concluded that myrrh and/or vitamin C administration able to minimize the toxic effects of TIL by its free radical-scavenging and potent antioxidant activity. Keywords: tilmicosin; oxidative stress; myrrh; vitamin C; antioxidant; heart; mice 1. Introduction Tilmicosin (TIL) is ... ... middle of paper ... ...rtant component in the diet of many animals and human. It is highly water soluble and acts as an effective reducing agent. It is most effective antioxidant in inhibiting lipid peroxidation initiated by peroxyl radicals, and considered as an effective free radical scavenger [33-34]. Moreover, it may regenerate other antioxidants such as vitamin E [35]. To our knowledge, the role of myrrh and vitamin C against TIL-induced serum biochemical alteration as well as lipid peroxidation and antioxidant status in mice has not been studied yet. Therefore, the present study was designed to investigate the alterations in serum biochemical parameters related heart damage as well as cardiac lipid peroxidation and oxidative stress induced by TIL in mice. Moreover, the role of myrrh or/and vitamin C supplementation in alleviating these TIL-induced hazard effects could be evaluated.

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