Aspirin, despite some of its affect to be a benefit to people with cardiovascular disease, is believed to have somewhat of an opposite affect when dealing with the gastrointestinal tract. The main objective for this paper was to see if the use of aspirin and or any other type of inflammatory medications had any effect on gastro intestinal bleeding. A 20 year prospective cohort study was used to effectively survey, and monitor a sample of individuals who reported using aspirin and a list of other inflammatory medications that the study deemed as close to aspirin as possible. In order to become a subject in the study, subjects were of male sex, specifically chosen from the HPFS (Health Professionals Follow-up Study) who chose to report their …show more content…
The first was they had longer follow up and much more recent information on the dosage of aspirin use. Second, as stated before, they collected data on aspirin before diagnosis so they concluded this would make the recall from their participants much more accurate. Third they minimized confounding of influence between variables by strategically estimating the different parameters of the use of aspirin as stated before (dosage, frequency etc.). Fourth they came to the conclusion that self-reports on aspirin from the participants would be of high accuracy since they were health professionals. Lastly the updated data they kept minimized residual confounding. There were also 5 limitations stated in the paper as well. The first was the questioning of the reliability of the results since the aspirin was self-selected. The second was the possibility of the number of cases of bleedings recorded in the study may not be a representation of the true number of all cases because it was only in 2006 when they started to assess bleeding in the GI. Third was a possibility for misclassification as stated earlier because they did not have exact dates and causes for their participant’s episode of bleeding. Fourth, as state before since the participant were mostly male, it limited generalizability to both sexes. The final limitation included an inflammatory drug called clopidogrel. In the questionnaire when they asked about the use of aspirin and other drugs similar to it, clopidogrel was on the list but the researchers ended up not take its use into consideration through 2006 even though there were reports of its use. The Study had a good group of male individuals to run their hypothesis on and even included females of similar status as far as eligibility to make it a little more generalizable. I feel it would be interesting and even beneficial to open this study up a bit more to include many different types of participants to possibly collect
Multiple studies have demonstrated the prophylactic effect of rectal declophenate (5-9) and rectal indomethacin (10, 11) or combined diclophenate and indomethacin (12), but no studies have evaluated the prophylactic effect of oral NSAIDs. On the other hand, Almeida et al demonstrated data on the ...
It has been argued that medication can contribute to pressure ulcers. Certain analgesics may reduce stimulus to relieve pressure ulcers. Non -steroidal anti-inflammatory drugs have been found to prevent inflammatory responses to pressure injuries thus worsening the condition. It has been found that nurses lack communication with a pharmacist regarding pressure ulcers in order to seek specialist advice (Royal college of nursing, 2001).
For example in the article relating to the assessment of PPI specifically their efficacy and safety shows better healing rates of Lansoprazole in shorter-term3. This study had conducted clinical trails on patients with duodenal ulcers and the results shown better healing results with Lansoprazole than Omeprazole within 2 weeks. Nevertheless, the overall rates of healing were the same after 4 weeks. That is why the results were not significant according to the author because both drugs were able to achieve the same end result3. The author of this article presents similar publications by different authors to show that his results are consistent with their findings. This shows consistency in regards to better healing rates of Lansoprazole that were observed after a short period of time and the same overall equivalent end result of both
Aspirin is much more than just a pill to take for aches, it has changed life for the better. It is used for medical purposes as well as everyday household needs. If people did not know about this simple yet life-changing molecule, the world would not be the same.
The fact the patient died from internal bleeding shows there were damages. The patient’s death was directly linked to the time delay finding the proper diagnosis, and inability to find the extent of internal bleeding from which he was
Whenever pain or a headache is felt people will immediately reach for the bottle of Aspirin they have in their medicine cabinet. For many years this has been the solution to any pain a person feels. As much as Aspirin will help to cure symptoms of pain it may also being doing the body harm. More and more studies have brought many harmful side effects to the surface. The question now comes into play of if Aspirin is actually doing more harm than good.
COX-1: Cox-1 is responsible to protect the lining of the stomach and to regulate blood platelets. It also decreases fever and regulates blood platelets promoting blood clotting. NSAIDS and aspirin can be used for inhibition of Cox-1 for the desirable effect of decreasing platelets aggregation, but it can also decrease the protection of stomach lining. As a result, it can cause bleeding and
2- In fact it is notorious clinical study. The patients should know the purpose, benefits and risks of the study. The patients had been mislead
This study will maintain every patient’s confidentiality who participate in this study. Only results of the study will be shared. To
discovered that the article described false evidence. It is crucial to trust the medical claim that
Describe the differences in the results between the groups in the study and support your description with examples from the study
A randomized trial of ondansetron for the treatment of irritable bowel syndrome with diarrhea, was a two-centre, double-blind, placebo controlled crossover study of ondansetron 4 mg/tablet versus placebo. The inclusion criteria of the study were age 18–75 years, IBS-D patients meeting the Rome III criteria, women of childbearing age should agree to have contraception during the study, no evidence of inflammatory bowel disease/microscopic colitis and able to give informed consent. The exclusion criteria were pregnancy or br...
Turner, B. J., Newschaffer, C. J., Zhang, D., Fanning, T., & Hauck, W. W. (1999). Translating clinical trial results into practice. Annals of Internal Medicine, 130(12), 979-986.
The study consisted of a significant number of females compared to males, which makes it invalid to conclude that the findings support the general population. A strength was that participants were selected at random. By doing so, the study remained unbiased, thus making the results more credible.
·Aspirin (salicylic acid acetate) is an anti-inflammatory (decreases swelling and inflammation), anti-pyretic (fever reducing), and anti-platelet (decreases platelets in the body to thin blood). Many heart treatment patients take an aspirin a day to prevent blood clotting. However, if aspirin is taken in large quantities over long periods of time, it may cause gastric ulcers or other internal damage. The molecular formula of aspirin is C9H8O4. Some examples of Aspirin are Bayer, Ecotrin, and Aspergum.