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A case report on organophosphate poisoning in a 24 year old male who ingested the parathion. He was treated by stomach wash, administration of pralidoxime, Atropine, Ceftriaxone, Oxygen support 2 lit/ml. Through the nasal prong, continuous cardiac monitoring and mechanical ventilator support for 13 days.
Keywords: Parathion, Pralidoxime, Atropine, Ceftriaxone etc.

A poison is any substance, which when administered to the body through any route, produces ill health, disease or death while poisoning refers to the damaging physiologic effects of ingestion, inhalation, or other exposure to a range of pharmaceuticals, illicit drugs and chemicals, including pesticide, heavy metals, gases/vapours and common household substances, such as bleach and ammonia. Poisoning is an important health problem in every country of the world1.
Parathion is a broad-spectrum insecticide used to control a wide variety of insects and mites. It is used in forestry, aquaculture, mosquito control and other non crop uses. Parathion usually refers to ethyl parathion rather than the closely related chemical methyl parathion, is one of a class of pesticides known as organophosphates. Among the most extremely acute toxic pesticides, parathion is notorious for the number and severity of human poisonings causes each year2. First introduced by Bayer AG. of Germany in 1947, with a U.S. registration in 1948. In the 1970’s approximately half the cases of world-wide pesticide poisonings were caused by parathion3.
The toxicity of parathion is caused by its metabolite paraoxon, which is 50 times as toxic as the parent compound Parathion. Along with other organophosphates, it binds irreversibly to the essential nervous system enzyme acetylcholine esterase (...

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...ce fluid 75 ml/hr.) given to the patient for the management of Parathion poisoning.
The therapeutic management of this patient including Atropine administration, atropine continue as main antidote of muscarinic effect from organophosphate poisoning but has no impact on neuromuscular effects or on pseudocholinesterase levels. Prolidoxime which acts synergistically with atropine at the initial acute phase organophosphate poisoning is the antidote of choice to control nicotinic manifestation.
Organophosphate poisoning is a common and acute problem in leading country because of due to easily available of pesticide. Young adult should be educated about poisoning hazards and should be aware about the poisoning. Clinical and health care professional should be provide technique in rural place, how to prevent and also give some tips about emergency condition.
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