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Background: Ethnic and regional variations has been found in the pharmacological treatment response. Though many efficacy studies have been conducted in India for antipsychotic treatment modalities of schizophrenia, there is a lack meta-analysis data of the existing literature from India. Aim: To conduct a systematic review and meta-analysis of the antipsychotic treatment trials of schizophrenia in the Indian context. Methodology: All controlled trials from India evaluating the clinical efficacy of antipsychotic treatment trials of schizophrenia were evaluated and 28 trials were included in the metanalysis. Effect sizes were computed using Cohen’s ‘d’ and risk of bias was evaluated. Results: Twenty eight studies were included in the metanalysis. Meta analysis revealed superiority of first generation antipsychotics over placebo (mean effect size [ES] of 1.387, confidence interval [CI] of 1.127 to 1.648). Second generation antipsychotics were marginally better than first generation antipsychotics (ES 0.106, CI 0.009 to 0.204). There was improvement in the methodology of the trials over...
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