It is important to have treatment available to patients who suffer from cardiovascular diseases. Since it is one of the leading causes of deaths in the United States, improving treatments will save many lives. Although heart disease occur more in adult patients, there are possible chances in which infants are affected by a disease known as the congenital heart disease. In order to have treatment for patient with heart disease, we need to look at the molecular level. Patients were examined and documents showed that endothelial injury may be the cause for pulmonary hypertension and other vascular diseases.
Endothelin is a 21 amino acid polypeptide that has 3 different isoforms which are endothelin-1(ET-1), endothelin-2 (ET-2), and endothelin-3 (ET-3). ET-1 is located mainly in the endothelial cell but is a regulator of smooth muscle, heart, and kidney. ET-2 differs from ET-1 by 2 amino acids and is also found in the heart and kidney. ET-3 differs from ET-1 by 6 amino acids and is produced in the central nervous system like ET-1and in gastrointestinal (1). With researches, ET-1 is more focused on in cardiovascu...
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...With different experimental data on animals and documents of patient with cardiovascular diseases, there no exact conclusion made on which receptors antagonist may cure the disease. Trials are needed to determine whether ETA/B blockage or just ETA blockade is better in the treatment of hypertension or any other vascular disease. Although both decrease vasoconstriction, potential anti-endothelin therapy is available to patients.
1. Agapotiv, Alexei & Haynes, William. “ Role of Endothelin in Cardiovascular Disease.” Journal of Renin0Angiotensin-Aldosterone System, 3.1 (2002): 2-10.
2. Bohm, Felix & Pernow, John. “The importance of endothelin-1 for vascular dysfunction in cardiovascular disease.” Cardiovascular Research, 76.1 (2007): 8-18.
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