The American Dental Association Council on Dental Therapeutics (CDT-1986) developed guidelines for the design of clinical trials. These guidelines require that clinical trials: be crossover or parallel-designed, study subjects should represent typical product users, active agent should be compared with a placebo or active control, dental plaque and gingivitis scoring be conducted at baseline, six months and an intermediate interval.3
The antiplaque agents (action through plaque effects) can be subdivided for possible modes of action against plaque: prevent bacterial attachment (antiadhesive); inhibit bacterial division (antimicrobial agents); remove plaque (“chemical tooth brush”); and alter plaque ecology. Of all, antimicrobial agents have had the most success, with little or no achievements in the other areas.4
To date, a wide variety of antimicrobial agents have been studied in respect to the control of supragingival plaque. These agents can be divided into bisguanides, quaternary ammonium comp...
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..., Afflitto J, Coleman EJ. The effect of triclosan on mediators of gingival inflammation. J Clin Periodontol 1995;22(6):480-484.
20. WHO. Oral Health Surveys, Basic Methods. 4th ed. 1997. p.7.
21. Lang NP, Hotz P, Graf H, Geering AH, Saxer UP, Sturzenberger OP, Meckel AH. Effects of supervised chlorhexidine mouth rinses in children. A longitudinal clinical trial. J Periodontal Res 1982;17(1):101-111.
22. Jenkins S, Addy M, Newcombe RJ. A dose-response study of triclosan mouthrinses on plaque regrowth. J Clin Periodontal 1993 Sep; 20(8):609-612.
23. Niklaus P, Lang, Brecx MC. Chlorhexidine digluconate- an agent for chemical plaque control and prevention of gingival inflammation. J Periodontal Res 1986; 21(Suppl. s16):74-89.
24. Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ 2010;340:c332.
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