Drugs Essay

Drugs Essay

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Lasix is known as the “water pill” it’s a diuretic administrated orally.(1) The active ingredient of Lasix is furosemide, but also includes a number of inactive ingredients including lactose monohydrate NF, magnesium stearate NF, starch NF, talc USP, and colloidal silicon dioxide NF. (1) The peak effects of furosemide are typically seen within the first hour of two after a dose of the medication. (1). Lasix is prescribed for individuals to treat edema that may arise from congestive heart failure, liver cirrhosis or renal disease. (1) In adults, furosemide may also be taken to treat hypertension itself.(1) Furosemide comes in 20, 40, and 80mg tablets as well as oral suspensions.(2) Furosemide is absorbed rapidly from oral suspension at 50 minutes, and from tablets at 87 minutes.(2) Food may slow down the absorption of the drug and alter the bioavalibitly.(1) Furosemide binds to plasma proteins, albumin being the main plasma protein that furosemide binds to, at 91-99%, and peak plasma concentrations increase with the increase of a single dose.(2) Furosemide is excreted through the urine and the remainder is excreted in the feces. (2) The half-life for furosemide is approximately 2 hours but the diuretic effects last 6-8 hours. (2)
Dosage Schedules and Routes of Administration
Furosemide is available in tablets, sublingual tablets, oral suspension, and intravenously. (2) The recommended schedule dose for adults for an initial dose is 20 to 80mg. (3) The same dose as well as higher doses may be administered 6 to 8 hours following the previous dose if needed. (2) When titrating doses it may be raised by 20 to 40mg but not within 6 to 8 hours after the initial dose, and this may continue until the desi...

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...hat makes the length of time the the medication is active much longer. (1) After opiates bind opiates are bound to the receptor a messanger such as cyclic AMP express the symptoms that are shown.(1)

Mechanism of Toxicity
Buprenorphine is contraindicated in patients with patients who opiate agnoist hypersensitivity.(1) It has been shown that CNS and repiratory depression macy occur with therapeutic doses of buprenorphine and can increase with ethanol intoxication.(1) Buprenorphine increass the tone and decreases the contractions of smooth muscles of the gastrointestinal tract resulting in constipation.(1) The metabolism of buprenorphine is directed by CYP3A4 isozyme, when administer with protease inhibitors it may decrease the clearance of buprenorphine.(1) This will increase the the levels of the medication in the plasma and can experience toxic effects(1)

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