Children with Down syndrome or what they call trisomy 21 have a markedly increased risk of leukemia in childhood but as later on in adulthood its has less of a chance of happening. Children that acquire Down syndrome have a genetic mutation in the gene called GATA1. Trisomy 21 is the most observed abnormality seen at birth and occurs in about 1 to 700 individuals. Children that are born with Down syndrome have an increased risk of acute megakaryoblastic leukemia (AML) and also acute lymphoblastic leukemia (ALL). In studies it shows that approximately 4-5% of children that are born with Down syndrome are also born with transient myeloprolifative disorder (TMD), a clonal preleukemia characterized by an accumulation of immature megakaryoblasts in the fetal liver and peripheral blood (Mailnge 2012).
Acute Myeloid Leukemia develops when acquired changes in DNA of a developing marrow cell that which can turn into a leukemia cell that turns into a billion more cancerous cells. When AML is first found children will notice that their normal healthy blood cell has diminished quite drastically. One of the risk factors that can cause AML is outside exposure to the chemi...
... middle of paper ...
I have had personal experiences with the Down syndrome disease since my girlfriend’s brother has it. His name is Nick and at age 30 lives with Down syndrome. I see just how much of affects his daily life. Things I notice is he stutters when he tries to pronounce certain words, knows all the lines to the 3 stooges movies, remembers things that most people have no recollection of. He is very organized as everything has to be in the exact place it was before it was moved. It just amazing how many little quirks he has been most regular people have that too.
Hopefully one day this disease eventually gets cured. This is a disease that has one extra chromosome then you are supposing to. It’s a genetic disease that many doctors and psychologists are trying to find the answer too. But for now, those people with Down syndrome and leukemia will live a challenging life.
Need Writing Help?
Get feedback on grammar, clarity, concision and logic instantly.Check your paper »
- Human Down Syndrome As diseases evolves so does humans, in order to eradicate the threats of the tiny world. Dangers such as viruses and bacteria, but humans are one-step forward and develop vaccines and antibiotics. Currently, one disease humans cannot stop is Down syndrome. Down syndrome causes a person to have physical and learning disabilities. Both of these disabilities can be minor to severe. According to World of Health (2000), “physical problems include a small skull, a narrowed or flattened nose bridge, poor muscle tone, and multiple folds beneath the eyes” (para.... [tags: disabilities, chromosome 21]
1114 words (3.2 pages)
- Many times two diseases show links between themselves. One example of a link is Down’s syndrome and acute myeloid leukemia. Down’s syndrome is a chromosomal disorder, and acute myeloid leukemia is the most common form of acute leukemia. Patients who have both of these diseases have to be treated separately and differently than those who suffer from just one disease. The survival rates of DS-AML patients are exceptionally high, especially in young patients. As a patient’s age increases, their survival rating decreases, however, comparatively to survival rates of other cancer, their rates remain optimistically high even at an older age.... [tags: chromosomal disorder, genetic information]
956 words (2.7 pages)
- Leukemia is a form of cancer that starts in the stem cells of the bone marrow that make blood cells. A bone marrow is the material that fills the center of most bones which is where blood cells are made. Leukemia is basically a blood cancer where the cells do not form properly. Leukemia is found in blood cells and since blood cells do not have chromosomes or DNA then they cannot divide or reproduce like somatic cells do. Blood cells form in the bone marrow and when too many blood cells form in the human body then Leukemia cancer is developed.... [tags: Leukemia Cancer Essays]
2138 words (6.1 pages)
- The American Cancer Society stated “ AML (acute myeloid leukemia) is the second most common type of leukemia diagnosed in both adults and children.” (2014). Acute Myeloid Leukemia (acute myelogenous leukemia or AML) is one of the four main types of leukemia and can come with many different variations or mutations. The term “acute” refers to the disease’s fast acting progression and it is referred to as myelogenous leukemia because it affects the myeloid cells that under normal circumstances develop into mature blood cells.... [tags: Blood, Bone marrow, Leukemia, Red blood cell]
1052 words (3 pages)
- Currently, in the Unites States there are more than 250,000 Americans living with leukemia. Leukemia is cancer of the white blood cells, which help your body fight infection. Your blood cells form in your bone marrow. In leukemia, the bone marrow produces abnormal white blood cells; these cells crowd out the healthy blood cells, making it hard for blood to do its work ("Leukemia," 2013). Fifty four year old Regina was just diagnosed with leukemia. Upon assessment I gathered that she has never smoked in her life, she has the occasional glass of wine and loves to go for walk and hikes in the mountains.... [tags: Leukemia Patient Education]
1507 words (4.3 pages)
- Executive Summary Two promising therapies for leukemia patients are bone marrow transplantation and peripheral stem cell transplantation. Successful transplants require that two immunologic barriers be overcome: a host-versus-graft (HVG) reaction and a graft-versus-host (GVH) reaction. A myeloablative conditioning regimen, which involves a depletion of the patient’s immune system, usually precedes the transplantation of donor stem cells to control the HVG. However, twentyfive to 35% of patients undergoing bone marrow transplantation experience life-threatening transplant-related complications (Holler 1990).... [tags: Leukemia]
1376 words (3.9 pages)
- Leukemia Leukemia strikes all ages and both sexes. In 1995 approximately 20,400 people died from Leukemia. The all time five year survival rate is 38%. This rate has gone to 52% in the mid 1980’s. Approximately 25,700 cases were reported in 1995 alone(American Cancer Society-leukemia, 1995). Leukemia is a form of cancer in the blood cells. Most forms of Leukemia occur in the white blood cells. These abnormal cells reproduce in large quantities and look and perform differently than normal cells(MedicineNet- leukemia, 1997).... [tags: essays research papers]
798 words (2.3 pages)
- Leukemia Leukemia is a cancer that has had a significant effect on our society and with the developments of new drugs it may become treatable. Leukemia originates in the blood-forming organs which may include the lymph tissue and bone cells. In a person with leukemia the rate and the number of cells produced is altered. This altering can become fatal, or with proper treatment it can be subdued. There are two main types of leukemia which include "total" and "differential." These are mainly characterized by the appearance of white blood cells.... [tags: Cancer Health Medical Leukemia Essays]
662 words (1.9 pages)
- Leukemia Leukemia is a disease that affects blood-forming tissues, mainly bone marrow. Leukemia also affects the lymph glands and spleen. Leukemia causes the body to produce an extreme amount of abnormal white blood cells. This causes infections because the abnormal cells cannot stop infections like the normal cells do. Leukemia also causes anemia. Anemia is a disease in which the body makes less blood cells. This happens because the leukemic cells crowd the system. Leukemia also causes excessive bleeding.... [tags: Health Medical Cancer]
454 words (1.3 pages)
- Leukemia Leukemia is a group of blood diseases characterized by cancer of the blood forming tissues. It was discovered in Europe during the XIX century when a group of doctors directed by John Hughes Bennett tested their patients and discovered their elevated number of white blood cells.... [tags: Papers]
888 words (2.5 pages)