Differential Diagnosis of Multiple Sclerosis Essay

Differential Diagnosis of Multiple Sclerosis Essay

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Diagnosis of Multiple Sclerosis1
Multiple sclerosis will be diagnosed by Magnetic resonance imaging (MRI), spinal fluid changes and evoked potential recording. Evoked potential recording is method use to record brain waves using electrode taped. Duration taken between stimulation and response will be recorded. The duration is known as latency. The evoked potential recording which is normally used are such as
 visual evoked response (VER or VEP)
 Somatosensory evoked response or potential (SSER or SSEP)
 Auditory brain stem evoked response or potential (ABER or ABEP)

Differential Diagnosis of multiple sclerosis are as below 1 2
o Optic neuritis
o Clinically isolated syndrome or mono-symptomatic demyelination CNS vasculitis
o Tumefactive multiple sclerosis
o Marburg disease
o Schilder disease
o Neuromyelitis optica
o Balo concentric sclerosis

o Subacute myelo-optic neuritis
o Acute disseminated encephalomyelitis (ADEM)
o Bickerstaff brainstem encephalitis
o Chronic inflammatory demyelinating polyneuropathy (CIDP)
o Cogan syndrome
o Eale syndrome
o Anterior ischemic optic neuropathy (AION)
o Behçet disease
o Sarcoidosis
o Systemic sclerosis (scleroderma)
o Sjögren syndrome
o Systemic lupus erythematous (SLE)
o Susac syndrome
o Sneddon syndrome
o Antiphospholipid antibody syndrome













1. Optic neuritis
Optic neuritis is a neurological condition where there will is an inflammation of optic nerve. The cause of the condition is unknown. Although optic neuritis will be one of the most predominant clinical feature of multiple sclerosis but not all multiple sclerosis patient will have optic neuritis. Furthermore, in optic neuritis bilateral eyes will be affected. Fundoscopy is a specifi...


... middle of paper ...


...ra


There will be decrease in platelet count where it will caused coagulopathy this condition commonly occur in young women. Recurrent thrombosis will cause the symptoms will look similar to MS. Besides there is also an abnormalities present in MRI scan. There will be gray matter involvement. Clotting studies should be done for confirmation. Thrombocytopen will be seen in CBC.


1. http://www.nationalmssociety.org/What-is-MS/Definition-of-MS
2. http://mssociety.ca/en/pdf/ms-effects.pdf
3. http://www.nlm.nih.gov/medlineplus/tutorials/multiplesclerosis/nr229105.pdf
4. http://www.webmd.com/multiple-sclerosis/evoked-potential-test-for-multiple-sclerosis
5. http://library.med.utah.edu/kw/ms/dd.html
6. http://emedicine.medscape.com/article/1146199-differential
7. https://www.neurology.wisc.edu/publications/2007/neuro_2.pdf
8. http://www.who.int/csr/disease/marburg/en/


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