In the first database used, a study was found that was conducted by Brem et al, 15,318 women were eligible to participate. In order to participate, a woman had to be 25 years of age or older, asymptomatic, and have heterogeneously or extremely dense breasts. Women were excluded from the study if they were currently pregnant, breastfeeding, or planned on becoming pregnant within the next 15 months. Other exclusion criteria consisted of signs of breast cancer, having undergone surgical breast procedures in the past year, or receiving diagnosis or treatment for any cancer in the past year. Radiologists first examined the participant’s mammographic images. Then, with the mammography images visible, they reviewed the automated breast ultrasound images. The point of this study was to determine the incremental increase in cancer detection with automated breast ultrasound combined with screening mammography, as compared to mammography alone. 112 women with breast cancer were identified. Of these 112 women, 17 cancers were detected using screening mammography alone. 30 cancers were detected with automated breast ultrasound alone, and 65 cancers were detected with using mammography in conjunction with automated breast ultrasound. The combined approach of using both types of imagine yielded 7.3 cancers detected p...
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... being pregnant or currently still breastfeeding, or having had breast surgery in the past. The study included 1,668 women who were examined with digital screening mammography immediately followed by examination with 3D automated breast ultrasound. Screening mammography alone generated 4.2 cancers per 1,000 women screened. However, with the combined read of screening mammography and 3D automated breast ultrasound there was a yield of 6.6 cancers detected per 1,000 women screened. That increase of 2.4 cancers detected per 1,000 resulted in a relative increase of 57%. In medical terms, sensitivity refers to the ability of a test to accurately identify individuals with a certain disease. In this study, adding 3D automated breast ultrasound to digital mammography resulted in a 36.4% increase in sensitivity when compared to the sensitivity of screening mammography alone.
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