Diagnosing Lyme Disease

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TO DIAGNOSE DISEASE (Lyme borreliosis or Lyme disease)

Lyme borreliosis or Lyme disease (LD) is the most common tick –borne illness caused by a group of bacteria known as Borrelia burgdorferi, that are transmitted to humans following a bite from an infected ticks of the lxodes ricinus species complex (Steere et al, 2004) Tick bites often go unnoticed and can remain feeding on one for many days before going off. In United States all of the Lyme disease are caused by B. burgdorferisensu lato. In Europe and parts of Asia, B. garinii and B. afzelii are common than B. burgdorferi.The principal tick vector in the northeast and north central of the United States is Ixodes scapularis, and in the costal northwest Ixodes pacficus is the principal host reservoir. (Steere et al, 2004). This infection is the most common tick-borne disease in North America and Europe. (NHS, 2013) and parts of Asia (Strle et al 2006).19, 931 cases of Lyme Disease reported in 2006, to the Centres for Disease and Control and Prevention in the United State (CDC) producing an incident rate of about 6.7 per 100,000. However Lyme disease has been reported across many of the continental United States, almost 95% of the cases are from Mil-Atlantic, North central Region and 10 States of the Northeast, where the average incidence is 31.6 per 100,000.

According to Public Health England estimates, there are 2,000 to 3,000 cases of Lyme disease in England and Wales every year, and that close to 15%-20% of cases happen while people out of the country. The Lake District, Exmoor, the New Forest in Hampshire, parts of Wiltshire and Berkshire, Thetford Forest in Norfolk, the Yorkshire Moors, and the Scottish Highlands are areas of the United Kingdom with a high p...

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...f the cure course can be clarified by the tremendously high sensitivity of PCR, that can spot only a few DNA copies; and the postulation that spirochetes that were Protected in sequestered sites was accessible to the drugs only after treatment, thus discharging DNA at that time.An important factor is that PCR frequently becomes responsive only after a few days of cure.

In conclusion, molecular techniques show promise for the detection of Lyme disease and are the greatest appreciated techniques of detecting Lyme disease. For people with Lyme disease involving systems other than skin, PCR sensitivity is generally not high, with the rejection of people with LB. Besides is not regularly used in some countries. Therefore, an exciting alternative could be techniques for the determination of lipid peroxidation products that is improved during LB and other infections.

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