The disease Alper- Huttenlocher syndrome is a POLG gene related disorder. The POLG gene provides instructions for making the alpha subunits of the protein polymerase gamma. It also codes for the catalytic subunits of the mitochondrial DNA polymerase (Genetic Home Reference : Your Guide to Understanding Genetic Conditions, 2014). Alpers disease is a DNA polymerase (this is needed for POLG function) related disorder and it is caused by a mutation in the DNA polymerase, it is a biochemical defect. DNA polymerase is an enzyme that reads sequences of DNA. It is also responsible for coping and replicating cells genetic contents. Along with reading and replicating DNA polymerse also plays an important part in DNA repair. Th...
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...rrier parents (Nichols, 2013). However, this has not been approved and is very controversial approach, but this type of technology can lead to the understanding, prevention, or cure of the disease known as Alpers-Huttenlocher syndrome.
Euro, L. F. (2011, July 14). Nucleic Acids Research. Retrieved from Oxford University Press : http://ncbi.nlm.nih.gov
Genetic Home Reference : Your Guide to Understanding Genetic Conditions. (2014, Feburary 3). Retrieved from Alpers-Huttenlocher Syndrome: http://www.ghr.nlm.nih.gov/condition/alpers-huttenlocher-syndrome
Nichols, A. (2013, October 16). A Throw away Culture in Reporductive Medicine. Retrieved from Crisis Magazine: http://crisismagazine.com/.../a-throw-away-culture-in -reproductive-medicine
Pierce, b. (2010). Genetic Essentials: Concepts and Connections. . New York: W.H Freeman and Company.
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