The prevalence of essential hypertension has made it one of the most important public health issues in developed countries. Lifestyle modifications are promoted such as a reduction in dietary sodium, weight loss, increase in physical activity to reduce BP. Results from the PREMIER trial, show this can lower BP and reduce cardiovascular disease risk in prehypertensive patients and ...
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...cal for the future progress of therapeutic strategies to treat hypertension.
A complex combination of regulatory mechanisms determines normal control of BP, across multiple physiological systems (Figure 3.). Dysfunction in one or more of these controls causes a sustained increase in arterial pressure. Hypertension, which is defined as a persistent elevation in BP, is therefore the result of many potential causative mechanisms. Common pathways that are involved with increase in BP, have been targeted and these therapeutics are now well established in the treatment of essential hypertension. Refining clinical phenotypes, investigating genetic mechanisms and considering alternative pathways will provide further insights into this complex heterogeneous disorder and potentially develop more personalised and effective approaches for clinical management of hypertension.
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