Toxikinetics is concerned with the absorption, distribution, metabolism and excretion of a toxicant. A discussion on the ways in which phenol can become toxic, the ways in which the body naturally excretes phenol, and the way it breaks down phenol to detoxify it is needed.
3.1 Absorption
As was shown earlier, phenol has specific chemical and physical properties, but it’s specific lipophilic property is the most concerning. Exposure to phenol is a concern for mostly industrial workers, especially those employed in the tar sands and solvent areas. The general public is relatively safe from exposure to phenol. However, it should be noted that the general public should be aware of phenol exposure as many industrial products contain phenol, such as detergents and synthetic fibres. Since phenol
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Absorption through the skin is considered the primary route of exposure in the work force . he major receptor sites are the gastrointestinal tract, along with the liver, lungs, and kidneys. The liver and the intestines have a large capacity to conjugate phenol and following this process, phenol gets excreted out in urine, which will be later explained in metabolism. Since phenol is highly soluble in water, an aqueous solution of phenol enhances the dermal absorption. Dermal exposure is relatively the worst kind for humans, where conjugates don’t develop as readily through this route. However, it should be noted that human skin does have a natural barrier to dermally exposed phenol concentrations. A study done shows that 8 men and women were exposed dermally to
Med-Pharmex Incorporated is known nationally and abroad as a pharmaceutical manufacturer of animal-related products. Before gaining fame worldwide, the business began its journey to success as a small lab in 1983, which slowly grew over time. Since then, the company maintains its main goal, and that is to produce drugs that promote the health of companion animals, such as dogs, cats, and horses, as well as food-producing animals, such as pork and chickens. To ensure legal responsibility, the company’s manufacturing process is examined by the United States Food and Drug Administration (FDA). Med-Pharmex works closely with veterinary clinics who purchase their life-saving drugs and represent them in the market. Despite manufacturing drugs, the
Located between the Moldovan-Ukrainian border and the River Dniester, the territory of Transnistria covers approximately 4160 km2 where over half million people live (Blakkisrud and Kolstø, 2013). In 1992, the civil conflict broke out in Transnistria (Cantir and Kennedy, 2015). When the former 14th Soviet Army interfered with the insurgent side, the Moldovans had to withdraw (Blackkisrud and Kolstø, 2013). It was thanks to Moscow that the attacks and fighting between Moldova and Transnistria were ended in July 1992 (Chamberlain-Creanga and Allin, 2010). Russia´s economic interest in Transnistria resulted in foreign direct investment from Kremlin and Russia also provided a huge financial aid to them. This was also the case of Moscow´s humanitarian
4.Bressler, J. P. and Goldstein, G.W. "Mechanisms of Lead Toxicity." Biochemical Pharmacology. 1991; 41: 479-84.
EPA. (2009, December 29). Retrieved January 15, 2011, from Toxicity and Exposure Assessment for Children's Health: http://www.epa.gov/teach/
The manner in which a teratogen impacts the developing human may vary, though nicotine, caffine and medication consumption are all directly related to physical development. These are examples of habitual teratogens, each contributing to low birth weight and behavioral problems in adolescents. The level of influence of any given teratogen depends on many factors; the first, called the “threshold effect,” occurs when a relatively harmless teratogen in small quantity becomes toxic at a spe...
Chemical pollution into the environment can cause both genotypic and phenotypic changes in many organisms, including humans. More specifically, environmental pollutants like BPA can act as xenoestrogens (estrogen imitators), ultimately affecting hormonal activity and production in an organism. This alteration in activity and production can be termed as endocrine disruption. The endocrine system regulates a variety of processes responsible for growth and development, including gonadal formation and function, digestion, metabolism, sex differentiation, and embryonic development (reviewed by Flint et al., 2012). Chemicals that interfere with the function or structure of the endocrine system can be defined as endocrine disrupting compounds (EDCs) (US Environmental Protection Agency, 2007).
Toxicology." The Gale Encyclopedia of Science. Ed. K. Lee Lerner and Brenda Wilmoth Lerner. 4th ed. Detroit: Gale, 2008. Student Resources in Context. Web. 29 Apr. 2014.
The toxicity or carcinogenicity of every reagent used in this method has not been practically defined. Each chemical compound shall be treated as a potential health hazard. Exposure to these chemicals must be reduced to the lowest possible level by whatever means available.
Toxicology is the investigation of the unfavourable impacts of chemicals on living creatures. Forensic toxicology takes it above and beyond, including various related controls to aid in the location and elucidation of pills and harms poisons and drugs in medico legitimate passing examinations, human execution issues; e.g.,
CHEMICHALS: Scientist have defined hundreds of chemicals that can cause cancer in animals. These chemicals are also a cancer hazard for human beings if they become widespread in food supply, the general environment, or the living and working environment. In most cases, a chemical carcinogen enters the food supply as a food addi...
If some women are not willing to give up their cosmetics during pregnancy, the ingredients in makeup can be lethal to the fetus. Nail polishes and hair sprays contain substances called phthalates, which is more commonly known as a plasticizer and can be found in the material to make rain coats and garden hoses, and its purpose is to make plastic more flexible but still strong (“Controversy Over Phthalates in Cosmetics” par 1) .When phthalates are absorbed into the skin, they could harm the fetus and, in baby boys, they could cause irregular genitals. Another ingredient, methylisothiazoline (or MIT for short), can be found in everyday shampoos and body washes such as Head and Shoulders, Suave and Pantene Hair conditioner, products a pregnant woman may very well use, and tests have shown that exposure to this ingredient could cause abnormal brain development in the fetus ("Popular shampoos contain toxic chemicals linked to nerve damage" par 2). However, these chemicals can cause health defi...
Although companies across the globe continue to produce multiple polycarbonate #7 plastic products with BPA, more is being noticed about the adverse health effects to humans can be harmful. Testing on mice has proven that some exposure to BPA can be linked to Cancer and neurological disorders. In countries which have banned the use of BPA in different products, would agree that this chemical is toxic and dangerous. However, as long countries like the United States, who do not currently support banning BPA countrywide due to limited scientific data to back all claims, BPA will continue to be a global issue which continues to be hidden in the dark and a mystery globally
Lead and lead compounds can be highly toxic when eaten or inhaled. Although lead is absorbed very slowly into the body, its rate of excretion is even slower. Thus, with constant exposure, lead accumulates gradually in the body. It is absorbed by the red blood cells and circulated through the body where it becomes concentrated in the soft tissues, especially the liver and kidneys. Lead can cause damage in the central nervous system and apparently can damage the cells making up the blood-brain barrier that protects the brain from many harmful chemicals.
In recent years it has become clear that some environmental chemicals can cause risks to the developing embryo and fetus. Evaluating the developmental toxicity of environmental chemicals is now a prominent public health concern. The suspected association between TCE and congenital cardiac malformations warrants special attention because TCE is a common drinking water contaminant that is detected in water supplies throughout the U.S. and the world. There is a lot of concern about the clean up of toxic pollutants from the environment.
Some examples of harmful toxins with difficult names include diethanolamine (DEA), formaldehyde, glucocorticoids, and triethanolamine (TEA). We are exposed to toxic chemicals in many ways. We may breathe them in as sprays and powders, swallow chemicals on our lips and, even rub them on our skin. According to a team of researchers who conducted a study on the relationship between exposure to phthalates and DNA damage on human sperm, “cosmetics frequently contain enhancers that allow ingredients to penetrate deeper into the skin. Studies have found health problems in people exposed to common fragrance and sunscreen ingredients, including increased risk of sperm damage, feminization of the male reproductive system and low birth weight in girls” (Duty et al. 1164). There should be regulations banning toxic chemicals from personal care and beauty products because toxins are bad for our health (1), the consumer faith in cosmetic companies are suffering (2), and other countries recognized the effects and banned it while America has not