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...the human genome is something known as an Alu element. A quick wiki search will reveal that with more than a million Alu elements sprinkled throughout, this element serves as the “most abundant transposable element” in the human genome, about 10.7%. These active TEs can cause numerous problems. The textbook Essentials of Genetics provides several cases of the diseases caused by these Alu elements. For example an Alu element inserted into certain genes have been proven to cause: familial breast cancer (BRCA2 gene), hemophilia B (factor IX gene), acholinesterasemia (ChE gene), and neurofibromatosis (NF1 gene). “It is thought that about 0.2 percent of detectible human mutations may be due to transposable element insertions…About 10 percent of new mouse mutations and 50 percent of Drosophila are cause by insertions of transposable elements in or near genes” (Klug 276).
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